HLA-DRB1*04 subtypes are associated with increased inflammatory activity in early rheumatoid arthritis

British Journal of Rheumatology

Volumn 36, Issue 9, 1997, Pages 941-944

  Seidl, C ^a   Koch, U ^b   Buhleier, T ^a   Frank, R ^b   Moller B ^b   Markert, E ^c   Koller Wagner, G ^c   Seifried, E ^a   Kaltwasser, J P ^b  

^a Inst Transfus Med I   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c Department Clinical Research   (Germany)

Author keywords

Disease severity; Early rheumatoid arthritis; Genetics; HLA; HLA and disease association; Human leucocyte antigen; Rheumatoid factor; Sequence analysis

Indexed keywords

AMINO ACID; HLA DR ANTIGEN; RHEUMATOID FACTOR; HLA-DRB1 ANTIGEN;

ADULT; AGED; ALLELE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; EARLY DIAGNOSIS; FEMALE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; IMMUNOPATHOGENESIS; INFLAMMATION; JOINT; MAJOR CLINICAL STUDY; MALE; PATIENT; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN POLYMORPHISM; RHEUMATOID ARTHRITIS; RISK FACTOR; SEQUENCE ANALYSIS; TREATMENT INDICATION; CAUCASIAN; DNA SEQUENCE; GENETICS; HISTOCOMPATIBILITY TEST; IMMUNOLOGY; MIDDLE AGED;

ADULT; AGED; ALLELES; ARTHRITIS, RHEUMATOID; DISEASE PROGRESSION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HISTOCOMPATIBILITY TESTING; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; RHEUMATOID FACTOR; RISK FACTORS; SEQUENCE ANALYSIS, DNA;

EID: 0030612235     PISSN: 02637103     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/36.9.941     Document Type: Article

References (20)

1. Snowden N, Kay RA. Immunology of systemic rheumatoid disease. In: Saklatvala J, Walport MJ, eds. Immunology of rheumatoid disease. Br Med Bull 1995;51:437-48.
2. Winchester R. The molecular basis of susceptibility to rheumatoid arthritis. Adv Immunol 1994;56:389-466.
3. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understand the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
4. Hiraiwa A, Yamanaka K, Kwok WW, Mickelson EM, Masewicz S, Hansen JA et al. Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis. Proc Natl Acad Sci USA 1990;87:8051-5.
5. Weyand CM, Goronzy JJ. Inherited and noninherited risk factors in rheumatoid arthritis. Curr Opin Rheumatol 1995;7:206-13.
6. Weyand CM, Goronzy JJ. Disease mechanisms in rheumatoid arthritis: Gene dosage effect of HLA-DR haplotypes. J Lab Clin Med 1994;124:335-8.
7. McMahon MJ, Hillarby MC, Clarkson RW, Hollis S, Grennan DM. Major histocompatibility complex variants and articular disease severity in rheumatoid arthritis. Br J Rheumatol 1993;32:899-902.
8. Deighton CM, Cavanagh G, Rigby AS, Lloyd HL, Walker DJ. Both inherited HLA-haplotypes are important in the predisposition to rheumatoid arthritis. Br J Rheumatol 1993;32:893-8.
9. Weyand CM, McCarthy TG, Goronzy JJ. Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. J Clin Invest 1995;95:2120-6.
10. Gough A, Faint J, Salmon M, Hassell A, Wordsworth P, Pilling D et al. Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome. Arthritis Rheum 1994;37:1166-70.
11. Larsen A, Dale K, Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference film. Acta Radiol Diagn 1977;18:481-91.
12. Larsen A, Thoen J. Hand radiography of 200 patients with rheumatoid arthritis after an interval of one year. Scand J Rheumatol 1987;16:395-401.
13. Ritchie D et al. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med (NS) 1968;37:393-406.
14. Pincus T, Callhan LF, Vaughn WK. Questionnaire, walking time and button test measures of functional capacity as predictive markers for mortality in RA. J Rheumatol 1987;14:240-51.
15. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
16. Bein G, Gläser R, Kirchner H. Rapid HLA-DRB1 genotyping by nested PCR amplification. Tissue Antigens 1992;39:68-73.
17. Tiwari JL, Terasaki PI. HLA and disease association. Heidelberg: Springer-Verlag, 1985:20.
18. Emery P, Salmon M, Bradley H et al. Genetically determined factors as a predictor of radiological changes in patients with early symmetrical arthritis. Br Med J 1992;305:1387-9.
19. Toda Y, Minamikawa Y, Akagi S, Sugano H, Mori Y, Nishimura H et al. Rheumatoid-susceptible alleles of HLA-DRB1 are genetically recessive to non-susceptible alleles in the progression of bone destruction in the wrists and fingers of patients with RA. Ann Rheum Dis 1994;53:587-92.
20. Pincus T. Clinical observations often provide more accurate information concerning the longterm natural history and results of treatment for rheumatoid arthritis than structural research studies. Rheumatol Eur 1995;24(suppl. 2): 179-84.