Genetics of multiple sclerosis - How could disease-associated HLA-types contribute to pathogenesis?

Journal of Neural Transmission, Supplement

Volumn , Issue 49, 1997, Pages 177-194

  Martin, R ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNITY; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; HLA SYSTEM; HLA TYPING; HUMAN; IMMUNOPATHOGENESIS; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; PRIORITY JOURNAL; REVIEW; TWINS; ADULT; AMINO ACID SEQUENCE; CHEMISTRY; CHROMOSOME MAP; FAMILY; GENE; GENETICS; IMMUNOLOGY; MAJOR HISTOCOMPATIBILITY COMPLEX; PROTEIN SECONDARY STRUCTURE;

HLA DQ ANTIGEN; HLA DQW6; HLA DR ANTIGEN; HLA DR15; HLA-DQW6; HLA-DR15; MYELIN BASIC PROTEIN;

ADULT; AMINO ACID SEQUENCE; CHROMOSOME MAPPING; FAMILY; GENES, MHC CLASS II; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; PROTEIN STRUCTURE, SECONDARY; TWIN STUDIES;

EID: 0030612208     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6844-8_19     Document Type: Review

References (22)

1. Allegretta M, Albertini RJ, et al (1994) Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis. J Clin Invest 94: 105-109
2. Andersen LC, Beaty JS, et al (1991) Allelic polymorphism in transcriptional regulatory regions of HLA-DQβ genes. J Exp Med 173: 181-192
3. Baisch JM, Weeks T, et al (1990) Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med 322: 1836-1841
4. Beall SS, Concannon P, et al (1989) The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis. J Neuroimmunol 21: 59-66
5. Begovich AB, Helmuth RC, et al (1990) HLA-DP beta and susceptibility to multiple sclerosis: an analysis of caucasoid and Japanese patient populations. Hum Immunol 28: 365-372
6. Bertram J, Kuwert E (1982) HLA antigen frequencies in multiple sclerosis. Eur J Neurol 7: 74-79
7. Bodmer JG, Marsh SGE, et al (1994) Nomenclature for factors of the HLA system, 1994. Hum Immunol 41: 1-20
8. Boylan KB, Takahashi N, et al (1990) DNA length polymorphism 5′ to the myelin basic protein gene is associated with multiple sclerosis. Ann Neurol 27: 291-297
9. Brown JH, Jardetzky TS, et al (1993) Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364: 33-39
10. Brown MG, Driscoll J, et al (1991) Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes. Nature 353: 355-357
11. Bugawan TL, Angelini G, et al (1989) A combination of a particular HLA-DPb allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease. Nature 339: 470-473
12. Bulman DE, Ebers GC (1992) The geography of multiple sclerosis reflects genetic susceptibility. J Trop Geograph Neurol 2: 66-72
13. Bulman DE, Armstrong H, et al (1991) Allele frequencies of the third component of complement (C3) in MS patients. J Neurol Neurosurg Psychiatry 54: 554-555
14. Burns J, Rosenzweig A, et al (1983) Isolation of myelin basic protein-reactive T cell lines from normal human blood. Cell Immunol 81: 435-440
15. Ebers GC, Dessa Sadovnick A (1994) The role of genetic factors in multiple sclerosis susceptibility. J Neuroimmunol 54: 1-17
16. Filippi M, Horsfield MA, et al (1994) Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis. Neurology 44: 635-641
17. Francis DA, Batchelor JR, et al (1987) Multiple sclerosis in Northeast Scotland. An association with HLA-DQw1. Brain 110: 181-196
18. Fritz RB, McFarlin DE (1989) Encephalitogenic epitopes of myelin basic protein. In: Sercarz EE (ed) Antigenic determinants and immune response. Karger, Basel, pp 101-125 (Chem Immunol 46)
19. Fritz RB, Skeen MJ, et al (1985) Major histocompatibility complex-linked control of the murine immune response to myelin basic protein. J Immunol 134: 2328-2332
20. Gaisner CN, Johnson MJ, et al (1987) Susceptibility to multiple sclerosis associated with immurioglobulin gamma 3 restriction fragment length polymorphism. J Clin Invest 79: 309-313
21. Gorodezky C, Najera R, et al (1986) Immunogenetic profile of multiple sclerosis in Mexicans. Hum Immunol 16: 364-374
22. Haegert DG, Francis GS (1993) HLA-DQ polymorphisms do not explain HLA class II associations with multiple sclerosis in two Canadian patient groups. Neurology 43: 1207-1210