17β-estradiol, progesterone, and testosterone inversely modulate low- density lipoprotein oxidation and cytotoxicity in cultured placental trophoblast and macrophages

American Journal of Obstetrics and Gynecology

Volumn 177, Issue 1, 1997, Pages 196-209

  Zhu, X ^a   Bonet, B ^a   Knopp, R H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cytotoxicity; Low density lipoprotein oxidation; Placental cells; Sex steroids

Indexed keywords

ESTRADIOL; LOW DENSITY LIPOPROTEIN; PROGESTERONE; SEX HORMONE; TESTOSTERONE; LIPID PEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ARTICLE; CELL VIABILITY; CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPOPROTEIN METABOLISM; MACROPHAGE; OXIDATION; OXIDATIVE STRESS; PLACENTA; PLACENTA FUNCTION; PRIORITY JOURNAL; TISSUE CULTURE; TROPHOBLAST; AGAR GEL ELECTROPHORESIS; CELL CULTURE; CELL DEATH; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; METABOLISM; OXIDATION REDUCTION REACTION; PREGNANCY;

CELL DEATH; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; ESTRADIOL; FEMALE; HUMANS; LIPID PEROXIDES; LIPOPROTEINS, LDL; MACROPHAGES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PLACENTA; PREGNANCY; PROGESTERONE; TESTOSTERONE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TROPHOBLASTS;

EID: 0030612174     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(97)70462-9     Document Type: Article

References (24)

1. RH opp MS Magee Pregnancy and parturition 21st ed HD Patten A Fuchs B Hille A Scher R Steiner Textbook of physiology 1989 Saunders Philadelphia 380 407 2. Knopp RH, Zhu X-D, Lau JR, Walden CE. Sex hormones and lipid interactions: implications for cardiovascular disease in women. Endocrinologist 1994;4:286-301
2. MR Adams JR Kaplan SB Manuck DR Koritnik JS Parks MS Wolfe Inhibition of coronary artery atherosclerosis by 17β-estradiol in ovariectomized monkeys Arteriosclerosis 10 1990 1051 1057
3. J Haarbo P Leth-Espensen S Stender C. Christiansen Estrogen monotherapy and combined estrogen-progestogen replacement therapy attenuate aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits J Clin Invest 87 1992 1274 1279
4. MR Adams JK Williams JR. Kaplan Effect of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsiveness Arterioscler Thromb Vasc Biol 15 1995 562 570
5. MR Adams TB Clarkson DR Koritnik HA. Nash Contraceptive steroids and coronary artery atherosclerosis in cynomolgous macaques Fertil Steril 47 1987 1010 1018
6. MR Adams DL. Golden Atheroprotective effects of estrogen replacement therapy are antagonized by medroxyprogesterone acetate in monkeys [abstract] Circulation 92 Suppl I 1995 I627
7. C Mazière M Auclair MF Ronveaux S Salmon R Santus JC. Mazière Estrogens inhibit copper and cell-mediated modification of low density lipoprotein Atherosclerosis 89 1991 175 182
8. VA Rifici AK. Khachadurian The inhibition of low density lipoprotein oxidation by 17β-estradiol Metabolism 41 1992 1110 1114
9. AM Nègre-Salvayre T Pieraggi L Mabile R. Salvayre Protective effect of 17β-estradiol against the cytotoxicity of minimally oxidized LDL to cultured bovine aortic endothelial cells Atherosclerosis 99 1993 207 217
10. MTR Subbiah B Kessel M Agrawal R Rajan W Abplanalp Z. Rymaszewski Antioxidant potential of specific estrogens on lipid peroxidation J Clin Endocrinol Metab 77 1993 1095 1097
11. XD Zhu D Meekins B Bonet RH. Knopp Effects of sex hormones on susceptibility of low density lipoprotein to copper mediated oxidative modification [abstract] Clin Res 41 1993 26A
12. MN Sack DJ Rader RO Cannon III. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women Lancet 343 1994 269 270
13. CA Hubel MK McLaughlin RW Evans BA Hauth CJ Sims JM. Roberts Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum Am J Obstet Gynecol 174 1996 975 982
14. D Carone G Loverro P Greco P Capuano L. Selvaggi Lipid peroxidation products and antioxidant enzymes in red blood cells during normal and diabetic pregnancy Eur J Obstet Gynaecol 51 1993 103 109
15. Y Wang SW Walsh HH. Kay Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia Am J Obstet Gynecol 167 1992 946 949
16. PA Boyd A. Scott Quantitative structural studies on human placentas associated with pre-eclampsia, essential hypertension and intrauterine growth retardation Br J Obstet Gynaecol 92 1985 714 721
17. SG. Driscoll The pathology of pregnancy complicated by diabetes mellitus Med Clin North Am 49 1965 1053 1067
18. R. Naeye Effects of maternal cigarette smoking on the fetus and placenta Br J Obstet Gynaecol 85 1978 732 737
19. B Bonet A Chait AM Gown RH. Knopp Metabolism of modified LDL by cultured human placental cells Atherosclerosis 112 1995 125 136
20. 2 stimulation of progesterone secretion in cultured placental trophoblast J Lipid Res 32 1991 1073 1087
21. T Henriksen SA Evensen B. Carlander Injury to human endothelial cells in culture induced by low density lipoproteins Scand J Clin Lab Invest 39 1979 361 368
22. H Honjo K Tanaka J Yasuda Y Ohno J Kitawaki K Naitoh Serum estradiol 17-sulphate and lipid peroxides in late pregnancy Acta Endocrinol 126 1992 303 307
23. RB. Jaffe Endocrine physiology of the fetus and fetoplacental unit 3rd ed SSC Yen RB Jaffee Endocrinology 1991 Saunders Philadelphia 901 904
24. AL. Tappel Lipid peroxidation damage to cell components Fed Proc 32 1973 1870 1874