In vivo 31P magnetic resonance spectroscopy and morphometric analysis of the perfused vascular architecture of human glioma xenografts in nude mice

British Journal of Cancer

Volumn 75, Issue 10, 1997, Pages 1432-1438

  Van Der Sanden, B P J ^a   Rijken, P F J W ^a   Heerschap, A ^a   Bernsen, H J J A ^a   Van Der Kogel, A J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

31P magnetic resonance spectroscopy; Fluorescence microscopy; Tumour bioenergetic status; Vascular morphology

Indexed keywords

NUCLEOSIDE TRIPHOSPHATE; PHOSPHATE; NUCLEOTIDE; PHOSPHORUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FLUORESCENCE MICROSCOPY; GLIOMA; IMAGE ANALYSIS; MORPHOMETRICS; MOUSE; NONHUMAN; NUDE MOUSE; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; BRAIN TUMOR; CELL CULTURE; COMPARATIVE STUDY; DISEASE MODEL; ENERGY METABOLISM; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PERFUSION; VASCULARIZATION; XENOGRAFT;

ANIMALS; BRAIN NEOPLASMS; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GLIOMA; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, FLUORESCENCE; NUCLEOTIDES; PERFUSION; PHOSPHORUS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0030611926     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.246     Document Type: Article

References (31)

1. 31P MRS of experimental tumours. NMR Biomed 6: 345-365
2. Dewhirst MW, Secomb TW, Ong ET and Gross JF (1994) Determination of local oxygen consumption rates in tumours. Cancer Res 54(13): 3333-3336
3. 31P NMR. Proc Natl Acad Sci USA 90: 2646-2650
4. 15O perfusion measurements in the RIF-1 murine tumor in-vivo. Radiation Res 106: 122-131
5. Gerweck LE and Fellenz MP (1991) The simultaneous determination of intracellular pH and cell energy status. Radiation Res 125: 257-261
6. Gerweck LE, Seneviratine T and Gerweck KK (1993) Energy status and radiobiological hypoxia at specified oxygen concentrations. Radiation Res 135: 69-74
7. Groebe K and Vaupel P (1988) Evaluation of oxygen diffusion distances in human breast cancer xenografts using tumor-specific in-vivo data: role of various mechanisms in the development of tumor hypoxia. Int J Radiat Oncol Biol Phys 15: 691-697
8. Hodgkiss RJ, Jones G, Long A, Parrick J, Smith KA, Stratford MRI, and Wilson GD (1991) Flow cytometric evaluation of hypoxic cells in solid experimental tumours using fluorescence immunodetection. Br J Cancer 63: 119-125
9. Hossmann KA, Linn F and Okada Y (1992) Bioluminescence and fluoroscopic imaging of tissue pH and metabolites in experimental brain tumours of Cat. NMR Biomed 5: 259-264
10. Ikezaki K, Black KL, Conklin SG and Becker DP (1992) Histochemical evaluation of energy metabolism in rat glioma. Neurol Res 14(4): 289-293
11. Kallinowski F, Runkel S, Fortmeyer HP, Förster H and Vaupel P (1987) L-Glutamine: a major substrate for tumor cells in-vivo? J Cancer Res Clin Oncol 113: 209-215
12. Kreuzer F (1982) Oxygen supply to tissues: the Krogh model and its assumptions. Experientia 38: 1415-1426
13. Less JR, Skalak TC, Sevick EM and Jain RK (1991) Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res 51: 265-273
14. Loesberg C, van Rooij H, Nooijen WJ, Meijer AJ and Smets LA (1990) Impaired mitochondrial respiration and stimulated glycolysis by m-iodobenzylguanidine (MIBG). Int J Cancer 46: 276-281
15. Moon RB and Richards JH (1973) Determination of intracellular pH by 31P magnetic resonance. J Biol Chem 248: 7276-7280
16. 31P NMR for non-invasive evaluation of tumor metabolic status. Int J Radiat Oncol Biol Phys 12: 793-799
17. 31P nuclear magnetic resonance spectroscopy and laser doppler flowmetry. Int J Radiat Oncol Biol Phys 16: 1493-1500
18. Pianet I, Merle M, Labouesse J and Canioni P (1991) Phosphorus-31 nuclear magnetic resonance of C6 glioma cells and rat astrocytes: evidence for a modification of the longitudinal relaxation time of NTP and P during glucose starvation. Eur J Biochem 195: 87-95
19. Rhodes CG, Wise RJ, Gibbs JM, Frackowiak RS, Hatazawa J, Palmer AJ, Thomas DG and Jones T (1983) In-vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas. Ann Neurol 14(6): 614-626
20. Rijken PFJW, Bernsen HJJA and van der Kogel AJ (1995) Application of an image analysis system to the quantitation of tumor perfusion and vascularity in human glioma xenografts. Microvascular Res 50: 141-153
21. 31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intravessel oxyhemoglobin saturation status and tumor hypoxia. Cancer Res 48: 5440-5446
22. 31P NMR technique. J Biochem 94: 729-733
23. 31P MRS as a method of measuring pH in rat tumours. NMR Biomed 5: 351-359
24. 31P MRS observations of tumour energy metabolism. NMR Biomed 5: 279-289
25. Vaupel P (1974) Atemgaswechsel und Glucose-stoffwechsel von Implantations-tumoren (DS-Carcinosarkom) in-vivo. Akademie der Wissenschaften und der Literatur, Mainz 1: 78-97
26. Vaupel P (1996) Microcirculation and blood flow: major determinants of tumor tissue oxygenation. In rHErythropoietin in Cancer Supportive Treatment, Smith JF, Boogaerts MA and Ehmer BRM (eds), pp. 206-213. Marcel Dekker: New York
27. 2 tension measurements in a murine fibrosarcoma. Radiation Res 120: 477-493
28. Vaupel P, Kallinowski F and Okunieff P (1989b) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465
29. Vaupel P, Kelleher DK and Engel T (1994) Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour. Br J Cancer 69: 46-49
30. 31P MRS measurements, tumor size, cell survival, and hypoxic fraction in the murine EMT6 tumor. Mag Res Med 25: 217-232
31. Yoshii Y and Sugiyama K (1988) Intercapillary distance in the proliferating area of human glioma. Cancer Res 48: 2938-2941