Structureof KW-2228, a tailored human granulocyte colony-stimulating factor with enhanced biological activity and stability

FEBS Letters

Volumn 410, Issue 2-3, 1997, Pages 131-135

  Fujii, Isao ^a   Nagahara, Yoshitomo ^b   Yamasaki, Motoo ^b   Yokoo, Yoshiharu ^b   Itoh, Seiga ^b   Hirayama, Noriaki ^a  

^a TOKAI UNIVERSITY   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Conformation; Granulocyte colony stimulating factor; Lymphokine; Structure activity relationship; Tailored protein; X ray crystallography

Indexed keywords

RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; DISULFIDE; GRANULOCYTE COLONY STIMULATING FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG SCREENING; DRUG STRUCTURE; GRANULOPOIESIS; PRIORITY JOURNAL; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DISULFIDES; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030611887     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00538-3     Document Type: Article

References (20)

1. Klingemann H.-G. Can. Med. Assoc. J. 140:1989;137-142.
2. Souza L.M., Boone T.C., Gabriloe J., Lai P.H., Zsebo K.M., Murdock D.C., Chazin V.R., Bruszewski J., Lu H., Chen K.K., Barendt J., Platzer E., Moore M.A.S., Mertelsmann R., Welte K. Science. 232:1986;61-65.
3. Oh-eda M., Hasegawa M., Hattori K., Kuboniwa H., Kojima T., Orita T., Tomonou K., Yamazaki T., Ochi N. J. Biol. Chem. 265:1990;11432-11435.
4. Nocola N.A., Metcalf D., Matsumoto M., Johnson G.R. J. Biol. Chem. 258:1983;9017-9023.
5. Nagata S., Tsuchiya M., Asano S., Kaziro Y., Yamazaki T., Yamamoto O., Hirata Y., Kubota N., Oheda M., Nomura H., Ono M. Nature. 319:1986;415-418.
6. Komatsu Y., Matsumoto T., Kuga T., Nishi T., Sekine S., Saito A., Okabe M., Morimoto M., Itoh S., Okabe T., Takaku F. Jpn. J. Cancer Res. 78:1987;1179-1181.
7. Shimamura M., Kobayashi Y., Yuo A., Urabe A., Okabe T., Komatsu Y., Itoh S., Takaku F. Blood. 69:1987;353-355.
8. Kuga T., Komatsu Y., Yamasaki M., Sekine S., Miyaji H., Nishi T., Sato M., Yokoo Y., Asano M., Okabe M., Morimoto M., Itoh S. Biochem. Biophys. Res. Commun. 159:1989;103-111.
9. Okabe M., Asano M., Kuga T., Komatsu Y., Yamasaki M., Yokoo Y., Itoh S., Morimoto M., Oka T. Blood. 75:1990;1788-1793.
10. Nagahara Y., Konishi N., Yokoo Y., Hirayama N. J. Mol. Biol. 214:1990;25-26.
11. Lovejoy B., Cascio D., Eisenberg D. J. Mol. Biol. 234:1993;640-653.
12. Hill C.P., Osslund T.D., Eisenberg D. Proc. Natl. Acad. Sci. USA. 90:1993;5167-5171.
13. Sakabe N. Nucl. Instrum. Methods Phys. Res. Ser. A 303:1991;448-463.
14. Higashi T. J. Appl. Crystallogr. 22:1989;9-18.
15. Steigemann, W. (1989) A Program System for the Crystal Analysis of Proteins. Max-Planck Institut für Biochemie, Martensreid, Germany.
16. Brunger A.T., Kuriyan J., Karplus M. Science. 235:1987;458-460.
17. CCP4 (1979) The SERC(UK) Collaborative Computing Project No. 4. A suite of programs for protein crystallography, distributed from Daresbury Laboratory, Warrington WA4 4AD, UK.
18. Roussel, A. and Cambillau, C. (1991) Silicon Graphics Directory. Silicon Graphics, Mountain View, CA.
19. Kraulis P.J. J. Appl. Crystallogr. 24:1991;946-950.
20. Layton J.E., Morstyn G., Fabri L.J., Reid G.E., Burgess A.W., Simpson R.J., Nice E.C. J. Biol. Chem. 266:1991;23815-23823.