Selective antagonism of the AT1 receptor inhibits angiotensin II stimulated DNA and protein synthesis in primary cultures of human proximal tubular cells

Kidney International

Volumn 52, Issue 3, 1997, Pages 699-705

  Chatterjee, P K ^a   Weerackody, R P ^a   Mistry, S K ^a   Hawksworth, G M ^a   McLay, J S ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Angiotensin II; AT1 receptor; DNA synthesis; Losartan; PD 123319; Protein synthesis

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CELL PROTEIN; DNA; GROWTH FACTOR; LOSARTAN; RECEPTOR SUBTYPE; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; BIPHENYL DERIVATIVE; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; TETRAZOLE DERIVATIVE;

ADAPTATION; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN SYNTHESIS; RNA SYNTHESIS; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANGIOTENSIN II; BIPHENYL COMPOUNDS; CELLS, CULTURED; DNA; HUMANS; IMIDAZOLES; KIDNEY TUBULES, PROXIMAL; LOSARTAN; PROTEIN BIOSYNTHESIS; PYRIDINES; RECEPTORS, ANGIOTENSIN; TETRAZOLES;

EID: 0030611842     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.385     Document Type: Article

References (38)

1. NATH KA: Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kid Dis 20:1-17, 1992
2. WOLF G, NEILSON EG: Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia. Kidney Int 39:401-420, 1991
3. YOSHIDA Y, FOGO A, ICHIKAWA I: Glomerular hemodynamic changes vs. hypertrophy in experimental glomerular sclerosis. Kidney Int 35:654-660, 1989
4. WOLF G: Regulating factors of renal tubular hypertrophy. Clin Invest 71:867-870, 1993
5. BLANTZ RC: The glomerular and tubular actions of angiotensin II. Am J Kid Dis 10:2-6, 1987
6. ICHIKAWA I, HARRIS RC: Angiotensin actions in the kidney: Renewed insight into the old hormone. Kidney Int 40:583-596, 1991
7. NORMAN JT: The role of angiotensin II in renal growth. Renal Physiol Biochem 14:175-185, 1991
8. KATZ AM: Is angiotensin II a growth factor masquerading as a vasopressor? Heart Dis Stroke 1:151-154, 1992
9. WOLF G, NEILSON EG: Angiotensin II as a hypertrophogenic cytokine for proximal tubular cells. Kidney Int 43(Suppl 39):S100-S107, 1993
10. WOLF G, NEILSON EG: Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells. Am J Physiol 259:F768-F777, 1990
11. 1 receptor. Nephrol Dial Transplant 8:128-133, 1993
12. ANDERSON PW, DO YS, HSUEH WA: Angiotensin II causes mesangial cell hypertrophy. Hypertension 21:29-35, 1993
13. WOLF G, HABERSTROH U, NEILSON EG: Angiotensin II stimulates the proliferation and biosynthesis of type 1 collagen in cultured murine mesangial cells. Am J Pathol 140:95-107, 1992
14. WOLF G, KILLEN PD, NEILSON EG: Intracellular signalling of transcription and secretion of type IV collagen after angiotensin II-induced cellular hypertrophy in cultured proximal tubular cells. Cell Reg 2:219-227, 1991
15. JOHNSON RJ, ALPERS CE, YOSHIMURA A, LOMBARDI D, PRITZL P, SCHWARTZ SM: Renal injury from angiotensin II mediated hypertension. Hypertension 19:464-474, 1992
16. ROSENBURG ME, HOSETTER TH, KREN S, CHIELEWSKI D: Effect of angiotensin II and norepinephrine on early growth response genes in the rat kidney. Kidney Int 43:601-609, 1993
17. LEWIS EJ, LAWRENCE MD, HUNSICKER MD, BAIN RP, ROHDE RD: The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med 329:1456-1462, 1993
18. NORMAN JT, GALLEGO C, BRIDGEMAN DA, FOGO A, FINE LG: Enalapril ameliorates interstitial fibrosis in the remnant kidney of the rat. (abstract) J Am Soc Nephrol 3:746, 1993
19. ISHIDOYA S, MORRISEY J, MCCRACKEN R, REYES A, KLAHR S: Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction. Kidney Int 47:1285-1294, 1995
20. IKOMA M, KAWAMURA T, KAKINUMA Y, FOGO A, ICHIKAWA I: Cause of variable therapeutic efficiency of angiotensin converting enzyme inhibitors on glomerular lesions. Kidney Int 40:195-202, 1991
21. WOLF G: Vasoactive substances as regulators of renal growth. Exp Nephrol 1:141-151, 1993
22. RODILLA VR, HAWKSWORTH GM: Isolation and culture of human renal cortical cells with characteristics of proximal tubules, in Methods in Molecular Medicine: Human Cell Culture Protocols, edited by JONES GE, Totowa, Humana Press Inc., 1996, pp 409-417
23. LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951
24. MCLAREN J, WHITING PH, HAWKSWORTH GM: Maintenance of glucose uptake in suspensions and cultures of human proximal tubular cells. Toxicol Lett 53:237-241, 1990
25. MCLAY JS, CHATTERJEE PK, NICOLSON G, JARDINE AG, MCKAY NG, RALSTON SH, GRABOWSKI P, HAITES NE, MACLEOD AM, HAWKSWORTH GM: Nitric oxide production by human proximal tubular cells: A novel immuno-modulatory mechanism? Kidney Int 46:1043-1049, 1994
26. FINE L: The biology of renal hypertrophy. (Editorial Review) Kidney Int 29:619-634, 1989
27. HARRIS PJ, YOUNG JA: Dose-dependent stimulation and inhibition of proximal tubular sodium transport in the kidney. Pflügers Arch 367: 295-297, 1977
28. SCHUSTER VL, KOKKO JP, JACOBSON HR: Angiotensin II directly stimulates sodium transport in the rabbit proximal convoluted tubule. J Clin Invest 73:507-515, 1984
29. SASAMURA H, DZAU V, PRATT R: Desensitization of angiotensin receptor function. Kidney Int 46:1499-1501, 1994
30. STOLL M, STECKELINGS UM, PAUL M, BOTTARI SP, METZGER R, UNGER T: The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 95:651-657, 1995
31. NAKAJIMA M, HUTCHINSON H, FUJINAGA M, HAYASHIDA W, MORISHITA R, ZHANG L, HORIUCHI M, PRATT R, DZAU V: The angiotensin II type 2 (AT2) receptor antagonises the growth effects of the AT1 receptor: Gain-of-function study using gene transfer. Proc Natl Acad Sci USA 92:10663-10667, 1995
32. DOUGLAS JG, ROMERO M, HOPFER U: Signalling mechanisms coupled to the angiotensin receptor of proximal tubular epithelium. Kidney Int 42(Suppl 30):S43-S47, 1990
33. GOLDFARB DA, DIZ DI, TUBBS RR, FERRARIO CM, NOVICK AC: Angiotensin II receptor subtypes in the human renal cortex and renal cell carcinoma. J Urol 151:208-213, 1994
34. WEERACKODY RP, CHATTERJEE PK, MISTRY SK, HAWKSWORTH GM, MCLAY JS: Selective antagonism of the angiotensin AT1 receptor inhibits DNA and protein synthesis in primary cultures of rat proximal tubular cells. Exp Nephrol (in press)
35. MAURER HR: Towards chemically-defined, serum free media for mammalian cell culture, in Animal Cell Culture: A Practical Approach, edited FRESHNEY RI, Oxford, Oxford University Press, 1987, pp 13-30
36. WOLF G, MUELLER E, STAHL RAK, ZIYADEH FN: Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-β. J Clin Invest 92:1366-1372, 1993
37. KOIBUCHI Y, LEE WS, GIBBONS GH, PRATT RE: Role of transforming growth factor-β1 in the cellular growth response to angiotensin II. Hypertension 21:1046-1050, 1993
38. STOUFFER GA, OWENS GK: Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of TGF-β. Circ Res 70:820-828, 1992