5-HT(1A) and 5-HT(2A) receptor affinity and functional profile of some N-[3-(4-aryl-1-piperazinyl)propyl] derivatives of indolin-2(1 H)-one, quinolin-2(1 H)-one and isoquinolin-1(2H)-one. Part 30: Structure-activity relationship studies of CNS agents

Pharmazie

Volumn 52, Issue 6, 1997, Pages 423-428

  Mokrosz, M J ^a,c   Mokrosz, J L ^a   Duszynska B ^a   Deren Wesolek A ^a   Klodzinska A ^a   Kowalski, P ^b   Charakchieva Minol, S ^a   Tatarczynska E ^a   Kowalska, T ^b   Majka, Z ^b   Chojnacka Wojcik E ^a   Misztal, S ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b CRACOW UNIVERSITY OF TECHNOLOGY   (Poland)

^c NONE   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 [4 (3 CHLOROPHENYL) 1 PIPERAZINYL]PROPYL]INDOLIN 2(1H) ONE; SEROTONIN 1A AGONIST; SEROTONIN 2A ANTAGONIST; UNCLASSIFIED DRUG; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 4-IODO-2,5-DIMETHOXYPHENYLISOPROPYLAMINE; AMPHETAMINE DERIVATIVE; INDOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; KETANSERIN; PIPERAZINE DERIVATIVE; QUINOLONE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; ANIMAL; ANIMAL BEHAVIOR; BINDING COMPETITION; DRUG ANTAGONISM; DRUG EFFECT; HIPPOCAMPUS; IN VITRO STUDY; KINETICS; METABOLISM; PHYSICAL CHEMISTRY; RADIOASSAY; SYNTHESIS; WISTAR RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMPHETAMINES; ANIMALS; BEHAVIOR, ANIMAL; BINDING, COMPETITIVE; CHEMISTRY, PHYSICAL; HIPPOCAMPUS; INDOLES; ISOQUINOLINES; KETANSERIN; KINETICS; MALE; MICE; PIPERAZINES; QUINOLONES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030611721     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Misztal, S.; Bojarski, A.; Maćkowiak, M.; Boksa, J.; Bielecka, Z.: Med. Chem. Res. 2, 82 (1992)
2. Mokrosz, J. L.; Chojnacka-Wójcik, E.; Dereń-Wesołek, A.; Kłodzińska, A.; Maćkowiak, M.; Bielecka, Z.; Paluchowska, M. H.: Drug Des. Discovery 11, 197 (1994).
3. Mokrosz, J. L.; Duszyńska, B.; Paluchowska, M. H.; Charakchieva-Minol, S.; Mokrosz, M. J.: Arch. Pharm. (Weinheim) 328, 623 (1995)
4. Przegaliński, E.; Lewandowska, A.: J. Neural. Transm. 46, 303 (1979)
5. Price, L. H.; Charney, D. S.; Heninger, G. R.: Psychopharmacology 89, 38 (1986)
6. Raffa, R. B.; Shank, R. P.; Vaught, J. L.: Psychopharmacology 108, 320 (1992)
7. Mokrosz, J. L.; Dereń-Wesołek, A.; Tatarczyńska, E.; Duszyńska, B.; Bojarski. A. J.; Mokrosz, M. J.; Chojnacka-Wójcik, E.: J. Med. Chem. 39, 1125 (1996)
8. Berendsen, H. H. G.; Jenck, F.; Broekkamp, C. L. E.: Pharmacol. Biochem. Behav. 33, 821 (1989)
9. Berendsen, H. H. G.; Broekkamp, C. L. E.; Van Delft, A. M. L.: Eur. J. Pharmacol. 187, 97 (1990)
10. Tricklebank, M. D.; Forler, C.; Fozard, J. R.: Eur. J. Pharmacol. 106, 271 (1995)
11. Glennon, R. A.: Life Sci. 39, 825 (1986)
12. Darmani, N. A.; Martin, B. R.; Pondey, V.; Glennon, R. A.: Pharmacol. Biochem. Behav. 36, 901 (1990)
13. Mokrosz, M. J.; Strekowski, L.; Kozak, W. X.; Duszyńska, B.; Bojarski, A. J.; Dove, S.; Mokrosz, J. L.: Arch. Pharm. (Weinheim) 328, 659 (1995)
14. Mokrosz, J. L.; Bojarski, A. J.; Maćkowiak, M.; Bielecka, Z.; Boksa, J.: Pharmazie 49, 328 (1994)
15. Loev, B.; Kormendy, M. F.: J. Org. Chem. 30, 3166 (1965)
16. Mayer, F.; Zütphen, L.; Philipps, H.: Chem. Ber. 60, 858 (1927)
17. Freedman, H.; Frost, A. E.: J. Org. Chem 23, 1292 (1958)
18. Bojarski, A. J.; Cegła, M. T.; Charakchieva-Minol, S.; Mokrosz, M. J.; Maćkowiak, M.; Misztal, S.; Mokrosz, J. L.: Pharmazie 48, 289 (1993)