Detection of an Fe2+-protoporphyrin-IX intermediate during aspirin-treated prostaglandin H2 synthase II catalysis of arachidonic acid to 15-HETE

Biochemistry

Volumn 36, Issue 24, 1997, Pages 7527-7534

  Tang, Mark S ^a   Copeland, Robert A ^b   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONIC ACID; FERRIC ION; FERROUS ION; FREE RADICAL; HYDROGEN PEROXIDE; OXYGENASE; PEROXIDASE; PROSTAGLANDIN SYNTHASE; PROTOPORPHYRIN; 15 HYDROXY 5,8,11,13 ICOSATETRAENOIC ACID; 15-HYDROXY-5,8,11,13-EICOSATETRAENOIC ACID; ACETYLSALICYLIC ACID; HYDROXYICOSATETRAENOIC ACID; ISOENZYME; PROSTAGLANDIN SYNTHASE INHIBITOR; RECOMBINANT PROTEIN;

ARACHIDONIC ACID METABOLISM; ARTICLE; ENZYME ACTIVITY; ENZYME MECHANISM; INFLAMMATION; OXYGENATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; CATALYSIS; CHEMISTRY; HUMAN; KINETICS; METABOLISM; OXYGEN CONSUMPTION; SPECTROSCOPY;

ARACHIDONIC ACID; ASPIRIN; CATALYSIS; CYCLOOXYGENASE INHIBITORS; FERROUS COMPOUNDS; HUMANS; HYDROGEN PEROXIDE; HYDROXYEICOSATETRAENOIC ACIDS; ISOENZYMES; KINETICS; OXYGEN CONSUMPTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTOPORPHYRINS; RECOMBINANT PROTEINS; SPECTRUM ANALYSIS;

EID: 0030611613     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962750k     Document Type: Article

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