Selective expansion of γδ T cells among liver-derived lymphocytes of AIDS patients with disseminated Mycobacterium avium complex infection

Clinical Immunology and Immunopathology

Volumn 85, Issue 2, 1997, Pages 151-157

  Grottrup Wolfers E ^a   Grunewald T ^a   Strzelecki, R ^a   Fohle, H D ^a   Ruf, B ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; LIVER BIOPSY; LYMPHOCYTE; MALE; MYCOBACTERIOSIS; MYCOBACTERIUM INTRACELLULARE AVIUM; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; T LYMPHOCYTE; AGED; AIDS RELATED COMPLEX; ATYPICAL MYCOBACTERIOSIS; BIOPSY; BLOOD; CHEMISTRY; CYTOLOGY; MIDDLE AGED; PATHOLOGY;

LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGED; AIDS-RELATED OPPORTUNISTIC INFECTIONS; BIOPSY; FEMALE; HUMANS; LIVER; MALE; MIDDLE AGED; MYCOBACTERIUM AVIUM-INTRACELLULARE INFECTION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA;

EID: 0030611587     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1997.4410     Document Type: Article

References (24)

1. Janis, E. M., Kaufmann, S. H. E., Schwartz, R. H., and Pardoll, D. M., Activation of γδ+ T cells in the primary immune response to Mycobacterium tuberculosis. Science 244, 713-716, 1989.
2. Modlin, R. L., Pirmez, C., Hofmann, F. M., Torigian, V., Uyemura, K., Rea, T. H., Bloom, B. R., and Brenner, M. B., Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions. Nature 339, 544-548, 1989.
3. Lima, H. C., Vasconcelos, A. W., David, J. R., and Lerner, E. A., American cutaneous leishmaniasis: In situ characterization of the cellular immune response with time. Am. J. Trop. Med. Hyg. 50(6), 743-747, 1994.
4. Mombaerts, P., Arnoldi, J., RUSS, F., Tonegawa, S., and Kaufmann, S. H. E., Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen. Nature 365, 53-56, 1993.
5. Ladel, C. H., Hess, J., Daugelat, S., Mombaerts, P., Tonegawa, S., and Kaufmann, S. H. E., Contribution of α/β and γ/δ T lymphocytes to immunity against Mycobacterium bovis Bacillus Calmette Guérin: Studies with T cell receptor-deficient mutant mice. Eur. J. Immunol. 25, 838-846, 1995.
6. Kabelitz, D., Bender, A., Schondelmaier, S., Schoel, B., and Kaufmann, S. H. E., A large fraction of human peripheral blood γ/δ+ T cells is activated by Mycobacterium tuberculosis but not by its 65kd heat shock protein. J. Exp. Med. 171, 667-669, 1990.
7. Kabelitz, D., Bender, A., Prospero, T., Wesselborg, S., Janssen, O., and Pechold, K., The primary response of human γδ+ T cells to Mycobacterium tuberculosis is restricted to Vγ9 bearing cells. J. Exp. Med. 173, 1331-1338, 1991.
8. Bluestone, J. A., and Matis, L. A., TCR γδ+ cells: Minor redundant T-cell subset or specialized immune system component? J. Immunol. 142, 1785-1788, 1989.
9. Falini, B., Flenghi, L., Pileri, S., Pelicci, P., Fagioli, M., Martelli, M. F., Moretta, L., and Ciccone, E., Distribution of T cells bearing different forms of the T cell receptor γ/δ in normal and pathological human tissues. J. Immunol. 143, 2480-2488, 1989.
10. Pham, B. N., Mosnier, J. F., Walker, F., Njapoum, C., Bougy, F., Degott, C., Erlinger, S., Cohen, J. H., and Degos, F., Flow cytometry CD4+/CD8+ ratio of liver-derived lymphocytes correlates with viral replication in chronic hepatitis B. Clin. Exp. Immunol. 97(3), 403-410, 1994.
11. Seki, S., Abo, T., Masuda, T., Ohteki, T., Kanno, A., Takeda, K, Rikiishi, H., Nagura, H., and Kumagai, K., Identification of activated T cell receptor gamma delta lymphocytes in the liver of tumor bearing hosts. J. Clin. Invest. 86(2), 409-415, 1990.
12. De Maria, A., Ferrazin, A., Ferrini, S., Ciccone, E., Terragna, A., and Moretta, L., Selective increase of a subset of T cell receptor y6 lymphocytes in the peripheral blood of patients with human immunodeficiency virus type 1 infection. J. Infect. Dis. 165,917-919, 1992.
13. Havlik, J. A., Horsburgh, C. R., Jr, Metchock, B., Williams, P. P., Fann, S. A., and Thompson, S. E., Disseminated Mycobacterium avium complex infection: Clinical identification and epidemiologic trends. J. Infect. Dis. 165, 577-580, 1992.
14. Nightingale, S. D., Byrd, L. T., Southern, P. M., Jockusch, J. D., Cal, S. X., and Wynne, B. A., Incidence ofMycobacterium-aviumintracellulare complex bacteremia in human immunodeficiency virus-positive patients. J. Infect. Dis. 165, 1082-1085, 1992.
15. Kahn, S.A., Salzman, B. R., Klein, R. S., Mahadevia, P.S., Friedland, G. H., and Brandt, L. J., Hepatic disorders in aquired immunodeficiency syndrome: A clinical and pathological study. Am. J. Gastroenterol. 81, 1145-1148, 1986.
16. Benson, A. B., and Ellner, J. J., Mycobacterium avium complex infection in AIDS: Advances in theory and practice. Clin. Infect. Dis. 17, 2-20, 1993.
17. Hawkins, C. C., Gold, J. W. M., and Whirnbey, E., Mycobacterium avium complex infections in patients with aquired immunodeficiency syndrome. Ann. Intern. Med. 105,184-188, 1986.
18. Montes-Santiago, J., Gambon-Deza, F., Pacheco-Carracedo, M., and Cerda-Mota, T., Cellular immune response in tuberculosis: Analysis of T-lymphocytes and their subsets, B-lymphocytes and natural cytotoxic cells in different tuberculosis states and body fluids. Rev. Clin. Esp. 196(4),223-227, 1996.
19. Balbi, B., Valle, M. T., Odera, S., Giunti, D., Manca, F., Rossi, G. A., and Allegra, L., T-lymphocytea with gd+Vd2+ antigen receptors are present in increased proportions in a fraction of patients with tuberculosis or with sarcoidosis. Am. Rev. Respir. Dis. 148,1685-1690, 1993.
20. Tazi, A., Fajac, L, Soler, P., Valeyre, D., Caranel, J., Battesti, J. P., and Hance, A. J., Gamma/delta T-lymphocytes are not increased in number in granulomatous lesions of patients with tuberculosis or sarcoidosis. Am. Rev. Respir. Dis. 144, 1373-1375, 1991.
21. Poccia, F., Boullier, S., Lecoeur, H., Cochet, M., Poquet, Y., Colizzi, V., Fournie, J. J., and Gougeon, M. L., Peripheral V-γ9/Vδ2 T cell deletion and anergy to nonpeptic mycobacterial antigens in asymptomatic HIV-1-infected persons. J. Immunol. 157,449-461, 1996.
22. Pechhold, K, Wesch, D., Schondelmaier, S., and Kabelitz, D., Primary activation of Vγ9-expressing γδ T cells by Mycobacte-Hum tuberculosis: Requirement for Thl-type CD4 cell help and inhibition by IL-10. J. Immunol. 152, 4984-4992, 1994.
23. Clerici, M., and Shearer, G. M., A Thl-Th2 switch is a critical step in the etiology of HIV infection. Immun. Today 14, 107-111, 1993.
24. Kaufmann, S. H. E., and Ladel, C. H., Role of T cell subsets in immunity against intracellular bacteria: Experimental infection of knock-out mice with Listeria monocytogenes and Mycobacterium bovis BCG. Immunobiology 191, 509-519, 1994.