Nasal inhalation of I-menthol reduces respiratory discomfort associated with loaded breathing

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 1, 1997, Pages 309-313

  Nishino, Takashi ^a   Tagaito, Yugo ^a   Sakurai, Yasuyoshi ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MENTHOL;

ADULT; ARTICLE; BREATHING; BREATHING PATTERN; DYSPNEA; FEMALE; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RATING SCALE; RESPIRATORY AIRFLOW; THERMORECEPTOR; ARTIFICIAL VENTILATION; CLINICAL TRIAL; COLD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; RANDOMIZED CONTROLLED TRIAL;

ADULT; COLD; FEMALE; HUMANS; MALE; MENTHOL; RESPIRATION; RESPIRATION, ARTIFICIAL; THERMORECEPTORS;

EID: 0030611427     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.1.9609059     Document Type: Article

References (20)

1. Manning, H. L., and R. M. Schwartzstein. 1995. Pathophysiology of dyspnea. N. Engl. J. Med. 333:1547-1553.
2. Spence, D. P. S., D. R. Graham, J. Ahmed, K. Rees, M. G. Pearson, and P. M. A. Calverley. 1993. Does cold air affect exercise capacity and dyspnea in stable chronic obstructive pulmonary disease? Chest 103:693-696.
3. Sant'Ambrogio, G., O. P. Mathew, J. T. Fisher, and F. B. Sant'Ambrogio. 1983. Laryngeal receptors responding to transmural pressure, airflow and local muscle activity. Respir. Physiol. 54:317-330.
4. Mortola, J. P., S. Al-Shway, and A. Moworaj. 1983. Importance of upper airway airflow in the ventilatory depression of laryngeal origin. Pediatr. Rex. 17:550-552.
5. Sant'Ambrogio, G., O. P. Mathew, and F. B. Sant'Ambrogio. 1988. Characteristics of laryngeal cold receptors. Respir. Physiol. 71:287-298.
6. McBride, B. and W. A. Whitelaw. 1981. A physiological stimulus to upper airway receptors in humans. J. Appl. Physiol. 51:1189-1197.
7. Burgess, K. R., and W. A. Whitelaw. 1984. Reducing ventilatory response to carbon dioxide by breathing cold air. Am. Rev. Respir. Dis. 129:687-696.
8. Burgess, K. R., and W. A. Whitelaw. 1988. Effects of nasal cold receptors on pattern of breathing. J. Appl. Physiol. 64:371-376.
9. Sant'Ambrogio, G., F. B. Sant'Ambrogio, and O. P. Mathew. 1986. Effect of cold air on laryngeal mechanoreceptors in the dog. Respir. Physiol. 64:45-56.
10. Schwartzstein, R. M., K. Lahive, A. Pope, S. E. Weinberger, and J. W. Weiss. 1987. Cold facial stimulation reduces breathlessness induced in normal subjects. Am. Rev. Respir. Dis. 136:58-61.
11. Sant'Ambrogio, F. B., J. W. Anderson, and G. Sant'Ambrogio. 1991. Effect of l-menthol on laryngeal receptors. J. Appl. Physiol. 70:788-793.
12. Orani, G. P., J. W. Anderson, G. Sant'Ambrogio, and F. B. Sant'Ambrogio. 1991. Upper airway cooling and l-menthol reduce ventilation in the guinea pig. J. Appl. Physiol. 70:2080-2086.
13. Killian, K. J., S. C. Gandevia, E. Summers, and E. J. M. Campbell. 1984. Effect of increased lung volume on perception of breathlessness, effort, and tension. J. Appl Physiol. 57:686-691.
14. Winning, A. J., R. D. Hamilton, S. A. Shea, C. Knott, and A. Guz. 1985. The effect of airway anaesthesia on the control breathing and the sensation of breathlessness in man. Clin. Sci. 68:215-225.
15. Hamilton, R. D., A. J. Winning, A. Perry, and A. Guz. 1987. Aerosol anesthesia increases hypercapnic ventilation and breathlessness in laryngectomized humans. J. Appl. Physiol. 63:2286-2292.
16. Remmers, J. E., J. G. Brooks, and S. M. Tenney. 1968. Effect of controlled ventilation on the tolerable limit of hypercapnia. Respir. Physiol. 4:78-90.
17. Manning, H. L., R. Basner, J. Ringler, C. Rand, V. Fencl, S. E. Weinberger, J. W. Weiss, and R. M. Schwartzstein. 1991. Effect of chest wall vibration on breathlessness in normal subjects. J. Appl. Physiol. 71:175-181.
18. Sibuya, M., M. Yamada, A. Kanamaru, K. Tanaka, H. Suzuki, E. Noguchi, M. D. Altose, and I. Homma. 1994. Effects of chest wall vibration on dyspnea in patients with chronic respiratory disease. Am. J. Respir. Crit. Care Med. 149:1235-1240.
19. Simon, P. M., R. C. Basner, S. E. Winberger, V. Fencl, J. W. Weiss, and R. M. Schwartzstein. 1991. Oral mucosal stimulation modulates intensity of breathlessness induced in normal subjects. Am. Rev. Respir. Dis. 144:419-422.
20. Killian, K. J., and E. J. M. Campbell. 1985. Dyspnea. In C. Roussos and P. T. Macklem, editors. The Thorax. Part B: Lung Biology in Health and Disease. Vol. 29. Marcel Dekker, New York. 787-828.