The spy genes on the Salmonella dublin virulence plasmid are required for severe enteritis and systemic infection in the natural host

Infection and Immunity

Volumn 65, Issue 5, 1997, Pages 1786-1792

  Libby, Stephen J ^a,e   Adams, L Garry ^b   Ficht, Thomas A ^b   Allen, Chris ^b   Whitford, Howard A ^c   Buchmeier, Nancy A ^d   Bossie, Stuart ^a   Guiney, Donald G ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c TEXAS A AND M UNIVERSITY SYSTEM   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; CATTLE; DIARRHEA; DISEASE SEVERITY; ENTERITIS; ENTEROCOLITIS; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SALMONELLA DUBLIN; SALMONELLOSIS; TRANSCRIPTION REGULATION; ANIMAL; ANIMAL SALMONELLOSIS; BLOOD; CELL CULTURE; FEMALE; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; ILEUM; MACROPHAGE; MICROBIOLOGY; OPERON; PATHOGENICITY; PATHOLOGY; SALMONELLA; VIRULENCE;

ANIMALS; CATTLE; CELLS, CULTURED; CLONING, MOLECULAR; DIARRHEA; ENTERITIS; ENTEROCOLITIS; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; ILEUM; MACROPHAGES; MICE; OPERON; PLASMIDS; SALMONELLA; SALMONELLA INFECTIONS, ANIMAL; TRANSCRIPTION, GENETIC; VIRULENCE;

EID: 0030610925     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.5.1786-1792.1997     Document Type: Article

References (53)

1. Abshire, K. Z., and F. C. Neidhardt. 1993. Analysis of proteins synthesized by Salmonella typhimurium during growth within a host macrophage. J. Bacteriol. 175:3734-3743.
2. Abshire, K. Z., and F. C. Neidhardt. 1993. Growth rate paradox of Salmonella typhimurium within host macrophages. J. Bacteriol. 175:3744-3748.
3. Barrow, P. A., and M. A. Lovell. 1988. The association between a large molecular mass plasmid and virulence in a strain of Salmonella pullorum. J. Gen. Microbiol. 134:2307-2316.
4. Beninger, P. R., G. Chikami, K. Tanabe, C. Roudier, J. Fierer, and D. G. Guiney. 1988. Physical and genetic mapping of the Salmonella dublin virulence plasmid pSDL2. J. Clin. Invest. 81:1341-1347.
5. Buchmeier, N., and F. Heffron. 1990. Induction of Salmonella stress proteins upon infection of macrophages. Science 248:730-732.
6. Buchmeier, N., and F. Heffron. 1991. Inhibition of macrophage phagosomelysosome fusion by Salmonella typhimurium. Infect. Immun. 59:2232-2238.
7. Buchmeier, N. A., and F. Heffron. 1989. Intracellular survival of wild-type Salmonella typhimurium and macrophage-sensitive mutants in diverse populations of macrophages. Infect. Immun. 57:1-7.
8. Buchmeier, N. A., S. J. Libby, Y. Xu, P. Lowewen, J. Switala, D. G. Guiney, and F. C. Fang. 1995. DNA repair is more important than catalase for Salmonella virulence in mice. J. Clin. Invest. 95:1047-1053.
9. Campbell, G. A., and G. L. Adams. 1992. The long term culture of bovine monocyte-derived macrophages and their use in the study of intracellular proliferation of Brucella abortus. Vet. Immunol. Immunopathol. 34:291-305.
10. Campbell, G. A., L. G. Adams, and B. A. Sowa. 1994. Mechanisms of binding of Brucella abortus to mononuclear phagocytes from cows naturally resistant or susceptible to brucellosis. Vet. Immunol. Immunopathol. 41:295-306.
11. Chen, .C.-Y., N. A. Buchmeier, S. J. Libby, F. C. Fang, M. Krause, and D. G. Guiney. 1995. Central regulatory role for the RpoS sigma factor in expression of Salmonella dublin plasmid virulence genes. J. Bacteriol. 177:5303-5309.
12. Chen, C.-Y., L. Eckmann, S. J. Libby, F. C. Fang, S. Okamoto, M. F. Kagnoff, J. Fierer, and D. G. Guiney. 1996. Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells. Infect. Immun. 64:4739-4743.
13. Chen, L. M., K. Kaniga, and J. E. Galan. 1996. Salmonella spp. are cytotoxic for cultured macrophages. Mol. Microbiol. 21:1101-1115.
14. Chikami, G. K., J. Fierer, and D. G. Guiney. 1985. Plasmid-mediated virulence in Salmonella dublin demonstrated by use of a Tn5-oriT construct. Infect. Immun. 50:420-424.
15. Cohen, S. N., and A. C. Y. Chang. 1978. Revised interpretation of the origin of the pSC101 plasmid. J. Bacteriol. 132:734-737.
16. Danbara, H., R. Moriguchi, S. Susuke, Y. Tamura, M. Kijima, K. Oishi, H. Matsui, A. Abe, and M. Kakmura. 1992. Effect of 50 kilobase-plasmid, pKDSC50, of Salmonella choleraesuis RF-1 strain on pig septicemia. J. Vet. Med. Sci. 54:1175-1178.
17. Fang, F. C., M. Krause, C. Roudier, J. Fierer, and D. G. Guiney. 1991. Growth regulation of a Salmonella plasmid gene essential for virulence. J. Bacteriol. 173:6783-6789.
18. Fang, F. C., S. J. Libby, N. Buchmeier, P. Loewen, J. Switala, and D. Guiney. 1992. Regulation of Salmonella virulence by an alternative sigma factor. Proc. Natl. Acad. Sci. USA 89:11978-11982.
19. Fierer, J., L. Eckmann, F. Fang, C. Pferfer, B. B. Finlay, and D. Guiney. 1993. Expression of the Salmonella virulence plasmid gene spvB in cultured macrophages and nonphagocytic cells. Infect. Immun. 61:5231-5236.
20. Fierer, J., and W. Fleming. 1983. Distinctive biochemical features of Salmonella dublin isolated in California. J. Clin. Microbiol. 17:552-554.
21. Fierer, J., L. Hatlen, J. Lin, D. Estrella, P. Mihalko, and A. Ya-Young. 1990. Successful treatment using gentamicin liposomes of Salmonella dublin infections in mice. Antimicrob. Agents Chemother. 34:343-348.
22. Grob, P., and D. G. Guiney. 1996. In vitro binding of the Salmonella dublin virulence plasmid regulatory protein SpvR to the promoter region of. spvA and spvR. J. Bacteriol. 178:1813-1820.
23. Guiney, D. G., F. C. Fang, M. Krause, and S. J. Libby. 1994. Plasmid-mediated virulence genes in non-typhoid Salmonella serovars. FEMS Microbiol. Lett. 3:275-279.
24. Guiney, D. G., F. C. Fang, M. Krause, S. J. Libby, N. Buchmeier, and J. Fierer. 1995. Biology and clinical significance of virulence plasmids in Salmonella. Clin. Infect. Dis. 21:S146-S151.
25. Guiney, D. G., J. Fierer, G. Chikami, P. Beninger, E. J. Heffernan, and K. Tanabe. 1988. Characterization of virulence plasmids in Salmonella, p. 329-345. In M. A. Horwitz (ed.), Bacteria-host cell interaction. Alan R. Liss, Inc., New York. N.Y.
26. Gulig, P. A. 1990. Virulence plasmids of Salmonella typhimurium and other Salmonellae. Microb. Pathog. 8:3-11.
27. Gulig, P. A., and R. I. Curtiss. 1987. Plasmid-associated virulence of Salmonella typhimurium. Infect. Immun. 55:2891-2901.
28. Gulig, P. A., and R. I. Curtiss. 1988. Cloning and transposon insertion mutagenesis of virulence genes of the 100-kilobase plasmid of Salmonella typhimurium. Infect. Immun. 56:3262-3271.
29. Gulig, P. A., H. Danbara, D. G. Guiney, A. J. Lax, F. Norel, and M. Rhen. 1993. Molecular analysis of spv virulence genes of the salmonella virulence plasmids. Mol. Microbiol. 7:825-830.
30. Gulig, P. A., and T. J. Doyle. 1993. The Salmonella typhimurium virulence plasmid increases the growth rate of salmonellae in mice. Infect. Immun. 61:504-511.
31. Hanahan, D., J. Jessee, and F. R. Bloom. 1995. Plasmid transformation of Escherichia coli and other bacteria. Methods Enzymol. 204:63-113.
32. Heffernan, E. J., J. Fierer, G. Chikami, and D. Guiney. 1987. Natural history of oral Salmonella dublin infection in BALB/c mice: effect of an 80-kilobasepair plasmid on virulence. J. Infect. Dis. 155:1254-1259.
33. Jones, G. W., D. K. Rabert, D. M. Svinarich, and H. J. Whitfield. 1982. Association of adhesive, invasive and virulent phenotypes of Salmonella typhimurium with autonomous 60-megadalton plasmids. Infect. Immun. 38:476-486.
34. Jones, P. W., G. Dougan, C. Hayword, N. Mackensie, P. Collins, and S. N. Chatfield. 1991. Oral vaccination of calves against experimental salmonellosis using a double aro mutant of Salmonella typhimurium. Vaccine 9:29-34.
35. Kowarz, L., C. Coynault, V. Robbe-Saule, and F. Norel. 1994. The Salmonella typhimurium katF(RpoS) gene: cloning, nucleotide sequence, and regulation of spvR and spvABCD virulence plasmid genes. J. Bacteriol. 176:6852-6860.
36. Krause, M., F. C. Fang, and D. G. Guiney. 1992. Regulation of plasmid virulence gene expression in Salmonella dublin involves an unusual operon structure. J. Bacteriol. 174:4482-1489.
37. Krause, M., and D. Guiney. 1991. Identification of a multimer resolution system involved in stabilization of the Salmonella dublin virulence plasmid pSDL2. J. Bacteriol. 173:5754-5762.
38. Krause, M., C. Roudier, J. Fierer, J. Harwood, and D. Guiney. 1991. Molecular analysis of the virulence locus of the Salmonella dublin plasmid pSDL2. Mol. Microbiol. 5:307-316.
39. Libny, S. J., W. Goebel, A. Ludwig, F. Bowe, N. Buchmeier, G. Songer, F. Fang, D. Guiney, and F. Heffron. 1994. A cytolysin from Salmonella typhimurium is required for survival in macrophages. Proc. Natl. Acad. Sci. USA 91:489-493.
40. Lindgren, S. W., I. Stojiljkovic, and F. Heffron. 1996. Macrophage killing is an essential virulence mechanism of Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 93:4197-4201.
41. Maloy, S. R., V. J. Stewart, and R. K. Taylor. 1996. Genetic analysis of pathogenic bacteria: a laboratory manual. Cold Spring Harbor Laboratory Press, Plainview. N.Y.
42. Manning, E. J., G. D. Baird, and P. W. Jones. 1986. The role of plasmid genes in the pathogenicity of Salmonella dublin. J. Med. Microbiol. 21:234.
43. Monack, D. M., B. Raupach, A. E. Hromoekyj, and S. Falkow. 1996. Salmonella typhimurium. invasion induces apoplosis in infected macrophages. Proc. Natl. Acad. Sci. USA 93:9833-9838.
44. Mukkur, T. K. S., K. H. Walker, D. Jones, E. Wronski, and D. N. Love. 1991. Immunizing efficacy of aromatic-dependent Salmonella dublin in mice and calves. Comp. Immunol. Microbiol. Infect. Dis. 14:243-256.
45. Neidhardt, F. C., J. L. Ingraham, K. B. Low, B. Magasanik, M. Schaochter, and H. E. Umbarger (ed.), 1987. Escherichia coli and Salmonella typhimurium: cellular and molecular biology, vol. 2. American Society for Microbiology, Washington. D.C.
46. Pardon, P., M. Y. Popoff, C. Coynault, J. Marly, and I. Miras. 1986. Virulence-associated plasmids of Salmonella serotype typhimurium in experimental murine infection. Ann. Inst. Pasteur 137B:47.
47. Qureshi, T., J. W. Templeton, and L. G. Adams. 1996. Intracellular survival of Brucella abortus. Mycobacterium bovis BCG, Salmonella dublin, and Salmonella typhimurium in macrophages from cattle genetically resistant to Brucella abartus. Vet. Immunol. Immunopathol. 50:55-66.
48. Rhen, M., P. Riikonen, and S. Taira. 1993. Transcriptional regulation of Salmonella enterica virulence plasmid genes in cultured macrophages. Mol. Microbiol. 10:45-56.
49. Riikonen, P., P. H. Makela, S. Sukupolvi, S. Taira, and H. Rhen. 1992. The virulence plasmid does not contribute to growth of Salmonella in cultured murine macrophages. Microb. Pathog. 13:281-291.
50. Roudier, C., J. Fierer, and D. G. Guiney. 1992. Characterization of translation termination mutations in the spv operon of the Salmonella virulence plasmid pSDL2. J. Bacteriol. 174:6418-6423.
51. Ruckebusch, Y., L.-P. Phaneuf, and R. Dunlop. 1991. Physiology of small and large animals. B. C. Decker, Inc., Philadelphia, Pa.
52. Segall, T., and A. A. Lindberg. 1991. Experimental oral Salmonella dublin infection in calves: a bacteriological and pathological study. J. Vet. Med. 38:169-185.
53. Wallis, T. S., S. M. Paulin, J. S. Plested, P. R. Watson, and P. W. Jones. 1995. The Salmonella dublin virulence plasmid mediates systemic but not enteric phases of salmonellosis in cattle. Infect. Immun. 63:2755-2761.