Characterization of antibiotic moenomycin A interaction with phospholipid model membranes

Chemistry and Physics of Lipids

Volumn 85, Issue 2, 1997, Pages 115-123

  Volke, F ^a   Waschipky, R ^a   Pampel, A ^a   Donnerstag, A ^b   Lantzsch, G ^a   Pfeiffer, H ^a   Richter, W ^c   Klose, G ^a   Welzel, P ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c Inst Ultrastrukturforschung K   (Germany)

Author keywords

Antibiotic; DSC; Electron microscopy; Interaction with membranes; MAS NMR

Indexed keywords

ANTIBIOTIC AGENT; CARBON 13; MOENOMYCIN A; PHOSPHOLIPID; BAMBERMYCIN; LIPOSOME; MEMBRANE LIPID; PHOSPHATIDYLCHOLINE;

ARTICLE; DRUG BINDING; DRUG STRUCTURE; ELECTRON MICROSCOPY; FREEZE FRACTURE; MEMBRANE STRUCTURE; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PHOSPHOLIPID MEMBRANE; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TEMPERATURE;

BAMBERMYCINS; CALORIMETRY, DIFFERENTIAL SCANNING; LIPOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE LIPIDS; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; TEMPERATURE;

EID: 0030610911     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(96)02649-7     Document Type: Article

References (19)

1. 31P-NMR investigations of phospholipids (II). Stud. Biophys. 76, 85-93.
2. 31P-NMR investigations of phospholipids (III). Stud. Biophys. 82, 207-214.
3. 1H-NMR study. J. Phys. Chem. 97, 2967-2973.
4. Crowe, J.H. and Crowe, L.M. (1984) Effects of dehydration on membranes and membrane stabilization at low water activities, in: Chapman, D. (Ed.) Biological Membranes, Vol. 5, Academic Press, London, pp. 57-103.
5. Donnerstag, A., Hennig, L., Findeisen, M., Welzel, P. and Haeßner, R. (1996) Magn. Reson. Chem. in press.
6. Donnerstag, A., Marzian, S., Müller, D., Welzel, P., Böttger, D., Stärk, A., Fehlhaber, U.-W., Markus, A., van Heijenoort, Y. and van Heijenoort, J. (1995) A structurally and biogenetically interesting moenomycin antibiotic. Tetrahedron 51, 1931-1940, and references therein.
7. Ghuysen, J.-M. and Hakenbeck, R. (1994) Bacterial Cell Wall, Elsevier, Amsterdam.
8. Hentschel, M., Volke, F., Arndt, D. and Reszka, R. (1991) Verfahren zur Stabilisierung von Vesikeln. Patent DO 290807 A5 (Germany).
9. Jain, M.K. (1983) Non-random lateral organization in bilayers and biomembranes, in: Aloia, R.C. (Ed.), Membrane Fluidity in Biology, Vol.1, Academic Press, Amsterdam.
10. Kempin, U., Hennig, L., Welzel, P., Marzian, S., Müller, D, Fehlhaber, H.-W., Markus, A., van Heijenoort, Y. and van Heijenoort, J. (1995) Introduction of a terminal hydroxy group into the lipid part of a moenomycin-type transglycosylase inhibitor suppresses antibiotic activity. Tetrahedron 51, 8471-8482.
11. Madden, T.D. and Cullis, P.R. (1981) Structural properties and functional roles of lipids. Biochim. Biophys. Acta 684, 149-153.
12. 4 at excess water. Chem. Phys. Lipids 71, 1-12.
13. Meyer, H. W., Richter, W. and Brezisinski, G. (1994) Convex-concave curvatures in bilayers of dipalmitoylphosphatidylcholine and cholesterol induced by amphotericin B - deoxycholate after prolonged storage. Biochim. Biophys. Acta 1190, 9-19.
14. Pfeiffer, H. (1995) Das thermotrope Phasenverhalten der Wasserdispersionen von Phospholipid/Wasser Mischsystemen. Diploma work, University Leipzig.
15. Sackmann, E. (1995) Physics of vesicles, in: Lipowsky, R. and Sackmann, E. (Eds.), Structure and Dynamics of Membranes, Vol. 1A, Elsevier, Amsterdam, pp. 286-292.
16. Santaren, M., Rico, M. and Kibua, A. (1983) in: Specinfo-data bank; Org. Magn. Reson. 21, 238.
17. 4. Biophys. J. 68, 1960-1965.
18. Volke, F., Pampel, A., Scott, R. and Bick, A. (1995) Water structure and dynamics in membranes studied with two-dimensional Magic Angle Spinning NMR. Bull. Magn. Reson. 17(1-4), 306.
19. Welzel, P. (1993) Transglycosylase Inhibition, in: Krohn, K., Kirst, H.A. and Maag, H. (Eds.), Antibiotics and Antiviral Compounds - Chemical Synthesis and Modifications, VCH Weinheim, pp. 373-378, and references therein.