Noncomplement fixing, IgG4 autoantibodies predominate in patients with anti-epiligrin cicatricial pemphigoid

Journal of Investigative Dermatology

Volumn 109, Issue 4, 1997, Pages 557-561

  Hsu, Roger ^a   Lazarova, Zelmira ^a   Yee, Carole ^a   Yancey, Kim B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Autoimmunity; Bullous disease; Laminin

Indexed keywords

AUTOANTIBODY; EPILIGRIN; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; KALININ; CELL ADHESION MOLECULE; COMPLEMENT; IMMUNOGLOBULIN G; LAMININ;

ARTICLE; AUTOIMMUNITY; BASEMENT MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSIS; EPIDERMIS CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MUCOUS MEMBRANE PEMPHIGOID; PATHOPHYSIOLOGY; PRIORITY JOURNAL; COMPLEMENT FIXATION TEST; FEMALE; IMMUNOLOGY; PREGNANCY; SERODIAGNOSIS;

AUTOANTIBODIES; BASEMENT MEMBRANE; CELL ADHESION MOLECULES; COMPLEMENT FIXATION TESTS; COMPLEMENT SYSTEM PROTEINS; FEMALE; HUMANS; IMMUNOGLOBULIN G; LAMININ; PEMPHIGOID, BENIGN MUCOUS MEMBRANE; PRECIPITIN TESTS; PREGNANCY;

EID: 0030610897     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12337073     Document Type: Article

References (27)

1. Aalberse RC, van der Gaag R, van Leeuwen J: Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J Immunol 130:722-726, 1983
2. Basset-Seguin N, Caughman SW, Yancey KB: A-431 cells and human keratinocytes synthesize and secrete the third component of complement. J Invest Dermatol 95:621-625, 1990
3. Bergamaschini L, Santangelo T, Faricciotti A, Ciavarella N, Mannucci PM, Agostoni A: Study of complement-mediated anaphylaxis in humans. J Immunol 156:1256-1261, 1996
4. Bird P, Friedmann PS, Ling N, Bird AG, Thompson RA: Subclass distribution of IgG autoantibodies in bullous pemphigoid. J Invest Dermatol 86:21-25, 1986
5. Burton DR, Gregory L, Jefferis R: Aspects of the molecular structure of the IgG subclasses. Monogr Allergy 19:7-35, 1986
6. 1 in epithelial basement membranes. Cell 65:599-610, 1991
7. Domloge-Hultsch N, Bisalbutra P, Gammon WR, Yancey KB: Direct immunoflourescence microscopy of 1 mol/L sodium chloride-treated patient skin. J Am Acad Dermatol 24:946-951, 1991
8. Domloge-Hultsch N, Gammon WR, Briggaman RA, Gil SG, Carter WG, Yancey KB: Epiligrin, the major human keratinocyte integrin ligand, is a target in both an acquired autoimmune and an inherited subepidermal blistering skin disease. J Clin Invest 90:1628-1633, 1992
9. Domloge-Hultsch N, Anhalt GJ, Gammon WR, Lazarova Z, Briggaman RA, Welch M, Jabs DA, Huff C, Yancey KB: Anti-epiligrin cicatricial pemphigoid: a subepithelial bullous disorder. Arch Dermatol 130:1521-1529, 1994
10. Gammon WR, Briggaman RA, Inman AO, Queen LL, Wheeler CE: Differentiating anti-lamina lucida and anti-sublamma densa anti-BMZ antibodies by indirect immunoflourescence on 1.0 mol/L sodium chloride separated skin. J Invest Dermatol 82:139-144, 1984
11. Iksander R, Das PK, Aalbese RC: IgG4 antibodies in Egyptian patients with schistosomiasis. Int Arch Allergy Appl Immunol 66:200-208, 1981
12. Jefferis R, Reimer CB, Skvaril F, DeLange G, Lang NR, Lowe J, Walker MR, Phillips DJ, Aloisio CH, Wells TW, Vaerman JP, Magnusson CG, Kubagawa H, Cooper M, Vartdal F, Vandvik B, Haaijman JJ, Makela O, Sarnesto A, Lando Z, Radl J, Molinaro G: Evaluation of monoclonal antibodies having specificity for human IgG subclasses. Results of an IUIS/WHO collaborative study. Immunol Lett 10:223-225, 1985
13. Jones CC, Hamilton RG, Jordon RE: Subclass distribution of human IgG autoantibodies in pemphigus. J Clin Immunol 8:43-49, 1988
14. Katz SI, Hertz KC, Yaoita H: Herpes gestationis: immunopathology and characterization of the HG factor. J Clin Invest 57:1434-1438, 1976
15. Kirtschig G, Marinkovich MP, Burgeson RA, Yancey KB: Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the α subunit of laminin 5. J Invest Dermatol 105:543-548, 1995
16. Lazarova Z, Domloge-Hultsch N, Yancey KB: Epiligrin is decreased in papulonodular basal cell carcinoma tumor nest basement membranes and the extracellular matrix of transformed human epithelial cells. Exp Dermatol 4:121-129, 1995
17. Lazarova Z, Yancey KB: Reactivity of autoantibodies from patients with defined subepidermal bullous diseases against 1 mol/L NaCl-split skin. J Am Acad Dermatol 35:398-403, 1996
18. Lazarova Z, Yee C, Darling T, Briggaman RA, Yancey KB: Passive transfer of antilaminin-5 antibodies induces subepidermal blisters in neonatal mice. J Clin Invest 98:1509-1518, 1996
19. Mooney E, Gammon WR: Heavy and light chain isotypes of immunoglobulin in epidermolysis bullosa acquisita. J Invest Dermatol 95:317-319, 1990
20. Ottesen EA, Skvaril F, Tripathy SP, Poindexter RW, Hussan R: Prominence of IgG4 in the IgG antibody response to human filariasis. J Immunol 134:2707-2712, 1985
21. Reimer CB, Phillips DJ, Aloisio CH, Moore DD, Galland GG, Wells TW, Black CM, McDougal JS: Evaluation of thirty-one mouse monoclonal antibodies to human IgG. Hybridoma 3:263-275, 1984
22. Rock B, Martins CR, Theofilopoulos AN, Balderas RS, Anhalt GJ, Labib RS, Futamura S, Rivitti EA, Diaz LA: The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem). N Engl J Med 320:1463-1469, 1989
23. Rousselle P, Lunstrum GP, Keene DR, Burgeson RE: Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol 114:567-576, 1991
24. Ryan M, Tizard R, VanDevanter D, Carter WG: Cloning of the LamA3 gene encoding the α3 chain of the adhesive ligand epiligrin. J Biol Chem 269:22779-22787, 1994
25. Schur PH: IgG subclasses - a review. Ann Allergy 58:89-99, 1987
26. Valin YML, Lachmann PJ: The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions. Clin Exp Immunol 84:1-8, 1991
27. van der Zee JS, van Swieten P, Aalberse RC: Serologic aspects of IgG4 antibodies. II. IgG4 antibodies form small, nonprecipitating immune complexes due to functional monovalency. J Immunol 137:3566-3571, 1986