'Wide-spectrum Ca2+ channel antagonists': Lipophilicity, inhibition, and recovery of secretion in chromaffin cells

European Journal of Pharmacology

Volumn 325, Issue 1, 1997, Pages 109-119

  Lara, Baldomero ^c   Gandía, Luis ^a   Torres, Andrés ^c   Olivares, Román ^a   Martínez Sierra, Rafael ^c   García, Antonio G ^a,b   López, Manuela G ^a  

^a AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^c UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

'Wide spectrum'; Ca2+ channel antagonist; Catecholamine release; Chromaffin cell; Dotarizine; Flunarizine; Lubeluzole

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; CALCIUM CHANNEL; CINNARIZINE; DOTARIZINE; FLUNARIZINE; FLUSPIRILENE; LIDOFLAZINE; LUBELUZOLE; N [1 [4 (4 FLUOROPHENOXY)BUTYL] 4 PIPERIDINYL] N METHYL 2 BENZOTHIAZOLAMINE; PENFLURIDOL; PIPERAZINE DERIVATIVE; BENZHYDRYL DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CATECHOLAMINE; POTASSIUM;

ANIMAL CELL; ARTICLE; CATECHOLAMINE RELEASE; CATTLE; CHROMAFFIN CELL; CONTROLLED STUDY; IN VITRO STUDY; LIPOPHILICITY; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; DRUG EFFECT; SECRETION;

ANIMALS; BENZHYDRYL COMPOUNDS; CALCIUM CHANNEL BLOCKERS; CATECHOLAMINES; CATTLE; CHROMAFFIN CELLS; FLUNARIZINE; PIPERAZINES; POTASSIUM; SECRETORY RATE;

EID: 0030610166     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00108-8     Document Type: Article

References (30)

1. 2 receptor binding in rat frontal cortex, Eur. J. Pharmacol. 183, 2147.
2. 2+ solutions, Pflügers Arch. Eur. J. Physiol. 432, 1030.
3. Binnie, C.D., F. De Beukelaar, J.W.A. Meijer, H. Meinardi, J. Overweg, A. Wauquier and A. Van Wieringen, 1985, Open dose ranging trial of flunarizine as add-on therapy in epilepsy, Epilepsia 26, 424.
4. Borges, R., F. Sala and A.G. García, 1986, Continuous monitoring of catecholamine release from perfused cat adrenals, J. Neurosci. Methods 16, 389.
5. Brasó, A., C. Cartheuser, A. Sacristán, and J.A. Ortíz, 1989, Dotarizine, a promising N-benhydryl-piperazine for migraine prophylaxis due to an additional antiserotoninergic effect. 4th Int. Symp. Calcium Antagonists, Pharmacol. Clin. Res., Florence, May 25-27, p. 261.
6. 1 receptors, XIIth Int. Congr. Pharmacol., Montreal, Canada.
7. 2 receptor blockade by flunarizine and cinnarizine explains extrapyramidal side effects, J. Cereb. Blood Flow Metab. 15, 513.
8. Cartheuser, C.F., A. Braso, A. Sacristán and J.A. Ortíz, 1994, Effects of dotarizine on peripheral and pulmonary circulation and cardiac dynamics in dogs, Pharmacology 48, 187.
9. De La Fuente, M.T., J.M. Guantes, M. Del Valle and A.G. García, 1992, Mechanism of blockade by flunarizine of bovine adrenal catecholamine release, Eur. J. Pharmacol. 229, 189.
10. Diener, H.C., 1994, A review of current treatments for migraine, Eur. Neurol. 34 (Suppl. 2), 18.
11. Fenwick, E.M., A. Marty and E. Neher, 1982, Sodium and calcium channels in bovine chromaffin cells, J. Physiol. 331, 599.
12. 2+ channel antagonists, Circ. Res. 52 (Suppl. 1), 3.
13. Gárcez-Do-Carmo, L., A. Albillos, A.R. Artalejo, M.T. De La Fuente, M.G. López, L. Gandía, P. Michelena and A.G. García, 1993. R56865 inhibits catecholamine release from bovine chromaffin cells by blocking calcium channels, Br. J. Pharmacol. 110, 1149.
14. 2+ channel antagonists, Am. J. Cardiol. 59, 11B.
15. Kaneda, M. and N. Akaike, 1989, The low-threshold Ca current in isolated amygdaloid neurons in the rat, Brain Res. 497, 187.
16. Livet, B.G., 1984, Adrenal medullary chromaffin cells in vitro, Physiol. Rev. 64, 1103.
17. 2+ channels dominate the control of secretion in bovine chromaffin cells, FEBS Lett. 349, 331.
18. 2+ oscillations induced by veratridine, Eur. J. Pharmacol. 279, 331.
19. 1 receptor, in bovine adrenal medulla, Mol. Pharmacol. 47, 40.
20. 2+ oscillations, Brain Res. 714, 209.
21. Micheli, F., M.F. Pardal, M. Gatto, M. Torres, G. Paradiso, I.C. Parera and R. Giannaula, 1987, Flunarizine and cinnarizine-induced extrapyramidal reactions, Neurology 37, 881.
22. Moro, M.A., M.G. López, L. Gandía, P. Michelena and A.G. García, 1990, Separation and culture of living adrenaline- and noradrenaline-containing cells from bovine adrenal medullae, Anal. Biochem. 185, 243.
23. Olivera, B.M., G. Miljanich, J. Ramachandran and M.E. Adams, 1994, Calcium channel diversity and neurotransmitter release: the ω-conotoxins and ω-agatoxins, Annu. Rev. Biochem. 63, 823.
24. Scheufler, E. and T. Peters, 1990, Phosphatidylserine monolayers as models for drug uptake into membranes and tissue, Cell Biol. Int. Rep. 14 381.
25. Takahashi, K. and N. Akaike, 1991, Calcium antagonist effects on low-threshold (T-type) calcium current in rat isolated hippocampal CA1 pyramidal neurons, J. Pharmacol. Exp. Ther. 256, 169.
26. 2+ movements and contractile responses in vascular smooth muscle, Eur. J. Pharmacol. 239, 75.
27. 2+ channel antagonist flunarizine to phosphatidylcholine bilayers: charge effects and thermodynamics, Biochem. J. 291, 397.
28. Todd, P.A. and P. Benfield, 1989, Flunarizine. A reappraisal of its pharmacological properties and therapeutic use in neurological disorders, Drugs 38, 481.
29. 2+ channel antagonists in chromaffin cells, Br. J. Pharmacol. 114, 369.
30. 2+ channels of chromaffin cells, Eur. J. Pharmacol. 320, 249.