Detective signal transduction through the thromboxane A2 receptor in a patient with a mild bleeding disorder: Deficiency of the inositol 1,4,5-triphosphate formation despite normal G-protein activation

Thrombosis and Haemostasis

Volumn 77, Issue 5, 1997, Pages 991-995

  Mitsui, Tetsuo ^a,b   Yokoyama, Shinkichi ^a   Shimizu, Yukitoshi ^a   Katsuura, Michihiko ^a   Akiba, Kaori ^a   Hayasaka, Kiyoshi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ARACHIDONIC ACID; CALCIMYCIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; INOSITOL 1,4,5 TRISPHOSPHATE; THROMBIN; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR; THROMBOXANE RECEPTOR STIMULATING AGENT; ADENOSINE DIPHOSPHATE; DRUG DERIVATIVE; PHOSPHOLIPASE C; PROSTAGLANDIN ENDOPEROXIDE; THROMBOXANE RECEPTOR;

ARTICLE; BINDING KINETICS; BINDING SITE; BLEEDING DISORDER; BLEEDING TIME; CASE REPORT; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; PRIORITY JOURNAL; SCHOOL CHILD; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE AGGREGATION; BLOOD; CHILD; DRUG EFFECT; IN VITRO STUDY; KINETICS; METABOLISM; PHYSIOLOGY; THROMBOCYTE DISORDER;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADENOSINE DIPHOSPHATE; BLOOD PLATELET DISORDERS; BLOOD PLATELETS; CALCIMYCIN; CHILD; FEMALE; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; KINETICS; PHOSPHOLIPASE C; PLATELET AGGREGATION; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; RECEPTORS, THROMBOXANE; SIGNAL TRANSDUCTION; THROMBIN; THROMBOXANE A2;

EID: 0030610093     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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