Predominant role of A1 adenosine receptors in mediating adenosine induced vasodilatation of rat diaphragmatic arterioles: Involvement of nitric oxide and the ATP-dependent K+ channels

British Journal of Pharmacology

Volumn 121, Issue 7, 1997, Pages 1355-1363

  Danialou, Gawiyou ^a   Vicaut, Eric ^b   Sambe, Abdoulaye ^a   Aubier, Michel ^a   Boczkowski, Jorge ^a  

^a INSERM   (France)

^b HÔPITAL FERNAND WIDAL   (France)

Author keywords

Adenosine receptors; Arterioles; Diaphragm; DMPX; DPCPX; DPMA; DPSPX; Glibenclamide; Nitric oxide; R PIA

Indexed keywords

1,3 DIPROPYL 8 (4 SULFOPHENYL)XANTHINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 3,7 DIMETHYL 1 PROPARGYLXANTHINE; 6 N CYCLOPENTYLADENOSINE; 6 N [2 (3,5 DIMETHOXYPHENYL) 2 (2 METHYLPHENYL)ETHYL]ADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE TRIPHOSPHATASE (POTASSIUM); ADENOSINE TRIPHOSPHATE; CROMOGLYCATE DISODIUM; GLIBENCLAMIDE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; ADENOSINE RECEPTOR; POTASSIUM;

ANIMAL TISSUE; ARTERIOLE; ARTICLE; CONTROLLED STUDY; DIAPHRAGM; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION; ANIMAL; DRUG EFFECT; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; ARTERIOLES; DIAPHRAGM; MALE; NITRIC OXIDE; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; VASODILATION;

EID: 0030610073     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701247     Document Type: Article

References (57)

1. ABEBE, W., HUSSAIN, T., OLANREWAJU, H. & MUSTAFA, J. (1995). Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery. Am. J. Physiol., 269, H1672-H1678.
2. BARK, H., SUPINSKI, G., BUNDY, R. & KELSEN, S. (1988). Effects of hypoxia on diaphragmatic blood flow, oxygen uptake, and contractility. Am. Rev. Respir. Dis., 138, 1535 1541.
3. BENYO, Z., KISS, G., SZABO, C., CSAKI, C. & KOVACH, A. (1992). Importance of basal nitric oxide synthesis in regulation of myocardial blood flow. Cardiovasc. Res., 25, 700 703.
4. BERNE, R. (1963). Cardiac nucleotides in hypoxia: Possible role in regulation of coronary blood flow. Am. J. Physiol., 204, 317 322.
5. BOCZKOWSKI, J., VICAUT, E. & AUBIER, M. (1990). A model for in vivo study of the diaphragmatic microcirculation in the rat. Microvasc. Res., 40, 157 167.
6. BOCZKOWSKI, J., VICAUT, E., GAWIYOU, D. & AUBIER, M. (1994). Role of nitric oxide and prostaglandins in the regulation of diaphragmatic arteriolar tone in rats. J. Appl. Physiol., 77, 590-596.
7. BRIDGES, A., BRUNS, R., ORTWINE, D., PRIEBE, S., SZOTEK, D. & TREVEDI, B. (1988). N6-[2-(3,5-dimethoxyphenil)-2-(2-melhylphenyl)-ethyladenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor. J. Med. Chem., 31, 1282-1285.
8. BRUNS, R.F., FERGUS, J.H., BADGER, E.W., BRISTOL, J.A., SANTAY, L.A., HARTMAN, J.D., HAYS, S.J. & HUANG, C.C. (1987). Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes. Naunyn-Schmiedberg's Arch. Pharmacol., 335, 59-63.
9. BUGA, G. & IGNARRO, L. (1992). Electrical-field stimulation causes endothelium-dependent and nitric oxide-mediated relaxation of pulmonary artery. Am. J. Physiol., 262, H973 H979.
10. CHI, L., FRIEDRICHS, G., GREEN, A. & LUCCHESI, B. (1994). Effect of Ado A1- and A2-receptor activation on ventricular fibrillation during hypoxia-reoxygenation. Am. J. Physiol., 267, H1447-H1454.
11. CUNHA, R., JOHANSSON, B., FREDHOLM, B., RIBEIRO, J. & SEBASTIAO, A. (1995). Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hyppocampus. Neurosci. Lett., 196, 41 44.
12. DALY, J., BRUNS, R. & SNYDER, S. (1981). Adenosine receptors in the CNS: Relationship to the central actions of methylxanthines. Life. Sci., 28, 2083-2097.
13. DALY, J., PADGETT, W., SHAMIN, M., BUTTS-LAMB, P. & WATERS, J. (1985). 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent watersoluble antagonists for A1 and A2 adenosine receptors. J. Med. Chem., 28, 487-492.
14. DART, C. & STANDEN, N. (1993). Adenosine-activated potassium current in smooth muscle isolated from the pig coronary artery. J. Physiol., 471, 767 786.
15. DOYLE, M., LINDEN, J. & DULING, B. (1994). Nucleoside-induced arteriolar constriction: a mast cell-dependent response. Am. J. Physiol., 266, H2042-H2050.
16. FABER, J. & HARRIS, P. (1981). Depression of arteriolar vasomotion in skeletal muscle of decerebrate rats by urethane-chloralose anesthesia. Bibl. Anat., 20, 553-556.
17. G-methylarginine. Biochem. Biophys. Res. Commun., 170, 96-103.
18. GUSTAFSSON, L., PERSSON, M., ÖHLEN, A., HEDQVIST, P. & LINDBOM, L. (1990). Adenosine modulation of resting vascular tone in rabbit skeletal muscle. Naunyn-Schmiedeberg's Arch. Pharmacol., 335, 64-69.
19. HAYNES, J., OBIAKO, B., THOMPSON, W. & DOWNE, J. (1995). Adenosine-induced vasodilation: receptor characterization in pulmonary circulation. Am. J. Physiol., 268, H1862-H1868.
20. G-monomethyl-L-arginine to citrulline and subsequently to L-arginine. Biochem. Biophys. Res. Commun., 167, 1037-1043.
21. HUSSAIN, S. (1996). Regulation of ventilatory muscles blood flow. J. Appl. Physiol., 81, 1455-1468.
22. HUSSAIN, S., ROUSSOS, C. & MAGDER, S. (1989). Effects of tension, duty cycle, and arterial pressure on diaphragmatic blood flow in dogs. J. Appl. Physiol., 66, 968-976.
23. HUSSAIN, S., STEWART, D. LUDEMANN, J. & MAGDER, S. (1992). Role of endothelium-derived relaxing factor in active hyperemia on the canine diaphragm. J. Appl. Physiol., 72, 2393 2401.
24. HUTCHINSON, A., WEBB, R., OEI, H., GHAI, G., ZIMMERMAM, M. & WILLIAMS, M. (1989). CGS 21680, and A2 selective adenosine receptor agonist with preferential hypotensive activity. J. Pharmacol. Exp. Ther., 251, 47 55.
25. INTAGLIETTA, M. & TOMPKINS, W. (1973). Microvascular measurements by video image shearing and splitting. Microvasc. Res., 5, 309 312.
26. JARVIS, M., SCHULZ, R., HUTCHINSON, A., DO, U., SILLS, M. & WILLIAMS, M. (1989). [3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain. J. Pharmacol. Exp. Ther., 251, 888 893.
27. + channels. Circ. Res., 74, 471-476.
28. KUSACHI, S., THOMPSON, R. & OLSSON, R (1983). Ligand selectivity of dog coronary adenosine receptor resembles that of adenosine cyclase stimulatory (Ra) receptors. J. Pharmacol. Exp. Ther., 227, 316-321.
29. LI, J.-M., FENTON, R., CUTLER, H. & DOBSON, Jr, J. (1995). Adenosine enhances nitric oxide production by vascular endothelial cells. Am. J. Physiol., 269, C519 0523.
30. MAKUJINA, S., OLANREWAJU, H. & MUSTAFA, S. (1994). Evidence against K ATP involvement in adenosine receptor-mediated dilation of epicardial vessels. Am. J. Physiol., 267, H716 H724.
31. + channels, potassium and muscle vasodilation in the rat systemic hypoxia. J. Physiol., 472, 1 9.
32. MARTIN, P. & POTTS, A. (1994). The endothelium of the renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5′-N-ethylcarboxamidoadenosine and N6-cyclopentiladenosine. J. Pharmacol. Exp. Ther., 270, 893 899.
33. MCBEAN, L. LAPPE, R., RIVERA, L., COX, B. & PERRONE, M. (1988). Effects of adenosine and its analogues on porcine basilar arteries: are only A2 receptors involved? J. Cereb. Blood Flow Metab., 8, 40 45.
34. MCCORMACK, D., CLARKE, B. & BARNES, P. (1989). Characterization of adenosine receptors in human pulmonary arteries. Am. J. Physiol., 25, H41-H46.
35. MERKEL, L., LAPPE, R., RIVERA, L., COX, B. & PERRONE, M. (1992). Demonstration of vasorelaxant activity with an A1-selective adenosine agonist in porcine coronary artery: involvement of potassium channels. J. Pharmacol. Exp. Ther., 260, 437 443.
36. 6-cycloalkyladenosines. Potent A1-selective adenosine agonists. J. Med. Chem., 28, 1383-1384.
37. MÜGGE, A., ANTONIO, J., LOPEZ, G., PIEGROS, D., BREESE, K. & HEISTAD, D. (1991). Acetylcholine-induced vasodilatation in rabbit hindlimb in vivo is not inhibited by analogues of L-arginine. Am. J. Physiol., 260, H242 H247.
38. MUSTAFA, S. & ASKAR, O. (1985). Evidence suggesting that an Ratype adenosine receptor in bovine coronary arteries. J. Pharmacol. Exp. Ther., 232, 49 56.
39. + channels is involved in arterial dilations to calcitonin gene-related peptide. Nature, 344, 770-773.
40. NGAI, A. & WINN, H. (1993). Effects of adenosine and its analogues on isolated intracerebral arterioles. Circ. Res., 73, 448 457.
41. PARK, T., GONZALES, E., SHAH, A. & GIDDAY, J. (1995). Hypoglycemia selectively abolishes hypoxic reactivity of pial arterioles in piglets: role of adenosine. Am. J. Physiol., 268, H871-H878.
42. PEET, N.P., LENTZ, N.L., MENG, E.C., DUDLEY, M.W., OGDEN, A.M., DEMETER, D.A., WEINTRAUB, H.J. & BEY, P. (1990). A novel sythesis of xanthines support for a new binding made for xanthines with respect to adenosine at adenosine receptors. J. Med. Chem., 33, 3127-3130.
43. PROCTOR, K. & STOJANOV, I. (1991). Direct vasoconstriction evoked by A1-adenosine receptor stimulation in the cutaneous microcirculation. Circ. Res., 68, 483-486.
44. RIBEIRO, J. (1995). Purinergic inhibition of neurotransmitter release in the central nervous system. Pharmacol. Toxicol., 77, 299-305.
45. ROSSI, N., CHURCHILL, P., ELLIS, V. & AMORE, B. (1988). Mechanism of adenosine receptor-induced renal vasoconstriction in rats. Am. J. Physiol., 255, H885-H890.
46. SEALE, T., ABLA, K., SHAMIM, M., CARNEY, J. & DALY, J. (1988). 3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs. Life Sci., 43, 1671-1684.
47. SHEPERD, R., LINDEN, J. & DULING, B. (1996). Adenosine-induced vasoconstriction in vivo. Role of the mast cell and A3 adenosine receptor. Circ. Res., 78, 627-634.
48. + channels in arterial smooth muscle. Science, 254, 177-180.
49. STOJANOV, I. & PROCTOR, K. (1989). Pharmacological evidence for A1 and A2 adenosine receptors in the skin microcirculation. Cire. Res., 65, 176-184.
50. SUPINSKI, G., DIMARCO, A., KETAI, D., HUSSEIN, F. & ALTOSE, M. (1988). Reversibility of diaphragm fatigue by mechanical hyperperfusion. Am. Rev. Respir. Dis., 138, 604-609.
51. SZENTMIKLOSI, A., UJFALUSI, A., CSEPPENTO, A., NOSZTRAY, K., KOVACS, P. & SZABO, J. (1995). Adenosine receptors mediate both contractile and relaxant effects of adenosine in main pulmonary artery of guinea pigs. Naunyn-Schmiedeberg's Arch. Pharmacol., 351, 417-425.
52. TABRIZCHI, R. & LUPICHUK, S. (1995). Vasodilation produced by adenosine in isolated rat perfused mesenteric artery: a role for endothelium. Naunyn-Schmiedeberg's Arch. Pharmacol., 352, 412-418.
53. UKENA, D., SHAMIM, M., PADGET, W. & DALY, J. (1986). Analogs of caffeine: antagonists with selectivity for A2 adenosine receptors. Life Sci., 39, 743-750.
54. VIALS, A. & BRUNSTOCK, G. (1993). A2-purinoreceptor mediated relaxation in guinea pig coronary vasculature: a role for nitric oxide. Br. J. Pharmacol., 109, 424-429.
55. WARD, M., MAGDER, S. & HUSSAIN, S. (1992). Oxygen delivery-independent effect of blood flow on diaphragm fatigue. Am. Rev. Respir. Dis., 145, 1058-1063.
56. WINER, B. (1971). Statistical Principles in Experimental Design. New York: McGraw-Hill.
57. ZWEIFACH, B. & LIPOWSKI, H. (1984). Pressure flow relations in blood and lymph microcirculation. In Handbook of Physiology. Vol. IV: The Cardiovascular System. ed. Renkin, E & Michels, C.C. pp. 252-305. Bethesda, MD: American Physiological Society.