Role of spinal δ1 and δ2 opioid receptors in the antinociception produced by microinjection of L-glutamate in the ventromedial medulla of the rat

Brain Research

Volumn 765, Issue 1, 1997, Pages 177-181

  Hammond, Donna L ^a   Donahue, Brian B ^a   Stewart, Peggy E ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Opioid receptor; 7 Benzylidinenaltrexone (BNTX); Antinociception; Naltriben (NTB); Nucleus raphe magnus; Nucleus reticularis gigantocellularis pars ; Spinal cord

Indexed keywords

GLUTAMIC ACID; RECEPTOR SUBTYPE; SIGMA OPIATE RECEPTOR; 7 BENZYLIDENENALTREXONE; 7-BENZYLIDENENALTREXONE; ANALGESIC AGENT; BENZYLIDENE DERIVATIVE; DELTA OPIATE RECEPTOR; DRUG DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; NALTREXONE; NALTRIBEN; NALTRINDOLE 5' ISOTHIOCYANATE; NALTRINDOLE 5'-ISOTHIOCYANATE; NARCOTIC ANTAGONIST;

ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; GIGANTOCELLULAR RETICULAR NUCLEUS; MEDULLA OBLONGATA; MICROINJECTION; NERVE TRACT; NONHUMAN; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAT; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; MALE; PAIN THRESHOLD; PHYSIOLOGY; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANALGESICS; ANIMALS; BENZYLIDENE COMPOUNDS; GLUTAMIC ACID; ISOTHIOCYANATES; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; NALTREXONE; NARCOTIC ANTAGONISTS; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; SPINAL CORD;

EID: 0030609985     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00658-6     Document Type: Article

References (34)

1. Aimone L.D., Jones S.L., Gebhart G.F. Stimulation-produced descending inhibition from the periaqueductal gray and nucleus raphe magnus in the rat: mediation by spinal monoamines but not opioids. Pain. 31:1987;123-136.
2. Aran S., Hammond D.L. Antagonism of baclofen-induced antinociception by intrathecal administration of phaclofen or 2-hydroxy-saclofen, but not delta-aminovaleric acid in the rat. J. Pharmacol. Exp. Ther. 257:1991;360-368.
3. A.D. Corbett, S.J. Paterson, H.W. Kosterlitz, Selectivity of ligands for opioid receptors, in: A. Herz (Ed.), Handbook of Experimental Pharmacology, Vol. 104, Springer-Verlag, Berlin, 1993, pp. 645-679.
4. D'Amour F.E., Smith D.L. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72:1941;74-79.
5. 5]enkephalin in the rat. J. Pharmacol. Exp. Ther. 259:1991;725-731.
6. G.F. Gebhart, Modulatory effects of descending systems on spinal dorsal horn neurons, in: T.L. Yaksh (Ed.), Spinal Afferent Processing, Plenum, New York, 1986, pp. 391-416.
7. D.L. Hammond, Control systems for nociceptive afferent processing: the descending inhibitory pathways, in: T.L. Yaksh (Ed.), Spinal Afferent Processing, Plenum, New York, 1986, pp. 363-390.
8. D.L. Hammond, Pharmacological mechanisms of pain modulation: an update on δ opioid receptors, in: C.R. Chapman, K.M. Foley (Eds.), Current and Emerging Issues in Cancer Pain: Research and Practice, Raven Press, New York, 1993, pp. 175-183.
9. Hammond D.L., Stewart P.E., Littell L. Antinociception and delta-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone. J. Pharmacol. Exp. Ther. 274:1995;1317-1324.
10. Hylden J.L.K., Thomas D.A., Iadarola M.J., Nahin R.L., Dubner R. Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms. Eur. J. Pharmacol. 194:1991;135-143.
11. 2]deltorphin, a novel and highly selective delta-opioid receptor agonist. Peptides. 13:1992;1123-1126.
12. Jensen T.S., Yaksh T.L. Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites. Brain Res. 321:1984;287-289.
13. Jensen T.S., Yaksh T.L. II. Examination of spinal monoamine receptors through which brainstem opiate-sensitive systems act in the rat. Brain Res. 363:1986;114-127.
14. S.L. Jones, Descending control of nociception, in: A.R. Light (Ed.), The Initial Processing of Pain and its Descending Control: Spinal and Trigeminal Systems, Vol. 12, Karger, Basel, 1992, pp. 203-295.
15. G. Keppel, Design and Analysis. A Researcher's Handbook, Prentice-Hall, Englewood Cliffs, NJ, 1973, 565 pp.
16. Malmberg A.B., Yaksh T.L. Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB). J. Pharmacol. Exp. Ther. 263:1992;264-275.
17. Mattia A., Farmer S.C., Takemori A.E., Sultana M., Portoghese P.S., Mosberg H.I., Bowen W.D., Porreca F. Spinal opioid delta antinociception in the mouse: mediation by a 5′-NTII-sensitive delta receptor subtype. J. Pharmacol. Exp. Ther. 260:1992;518-525.
18. A receptors. Brain Res. 620:1993;86-96.
19. B antagonists attenuate the antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat. Brain Res. 607:1993;39-46.
20. F. Porreca, T. Burks, Supraspinal opioid receptors in antinociception, in: A. Herz (Ed.), Opioids II, Vol. 104, Springer-Verlag, Berlin, 1993, pp. 21-51.
21. Porreca F., Mosberg H.I., Hurst R., Hruby V.J., Burks T.J. Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse. J. Pharmacol. Exp. Ther. 230:1984;341-348.
22. Russell R.D., Leslie J.B., Su Y.-F., Watkins W.D., Chang K.-J. Continuous intrathecal opioid analgesia: tolerance and cross-tolerance of mu and delta spinal opioid receptors. J. Pharmacol. Exp. Ther. 240:1987;150-158.
23. Satoh M., Oku R., Akaike A. Analgesia produced by microinjection of L-glutamate into the rostral ventromedial bulbar nuclei of the rat and its inhibition by intrathecal α-adrenergic blocking agents. Brain Res. 261:1983;361-364.
24. Sofuoglu M., Portoghese P.S., Takemori A.E. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. J. Pharmacol. Exp. Ther. 257:1991;676-680.
25. 1 opioid receptor antagonist in the mouse spinal cord. Life Sci. 52:1993;769-775.
26. 4]deltorphin. J. Pharmacol. Exp. Ther. 266:1993;820-828.
27. 2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat. J. Pharmacol. Exp. Ther. 268:1994;701-708.
28. 2-opioid receptors in the brain and spinal cord, respectively. Eur. J. Pharmacol. 242:1993;145-150.
29. Tiseo P.J., Yaksh T.L. Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for δ-opioid receptor subtypes in the rat. Eur. J. Pharmacol. 236:1993;89-96.
30. Tseng L.F., Collins K.A., Portoghese P.S. Spinal δ2 but not δ1 opioid receptors are involved in intracerebroventricular β-endorphin-induced antinociception in the mouse. Life Sci. 52:1993;PL211-PL215.
31. Woolfe G., MacDonald A.D. The evalution of the analgesic action of pethidine hydrochloride (Demerol). J. Pharmacol. Exp. Ther. 80:1944;300-307.
32. Zaki P.A., Bilsky E.J., Vanderah T.W., Lai J., Evans C.J., Porreca F. Opioid receptor types and subtypes: the δ opioid receptor as a model. Annu. Rev. Pharmacol. Toxicol. 36:1996;379-401.
33. Zhuo M., Gebhart G.F. Spinal cholinergic and monoaminergic receptors mediate descending inhibition from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Brain Res. 535:1990;67-78.
34. Zorman G., Belcher G., Adams J.E., Fields H.L. Lumbar intrathecal naloxone blocks analgesia produced by microstimulation of the ventromedial medulla in the rat. Brain Res. 236:1982;77-84.