In vivo uptake of [3H]nimodipine into brain during cortical spreading depression

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 5, 1997, Pages 586-590

  Osuga, Sachiko ^a   Hakim, Antoine M ^a   Osuga, Hitoshi ^a   Hogan, Matthew J ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

autoradiography; cortical spreading depression; nimodipine; voltage sensitive calcium channels

Indexed keywords

CALCIUM CHANNEL; CARBON 14; IODOPHENAZONE; NIMODIPINE; TRITIUM; CALCIUM CHANNEL BLOCKING AGENT;

ARTICLE; AUTORADIOGRAPHY; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG UPTAKE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPREADING CORTICAL DEPRESSION; ANIMAL; BRAIN CORTEX; DRUG EFFECT; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; AUTORADIOGRAPHY; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CEREBRAL CORTEX; HIPPOCAMPUS; MALE; NIMODIPINE; RATS; RATS, SPRAGUE-DAWLEY; SPREADING CORTICAL DEPRESSION; TISSUE DISTRIBUTION;

EID: 0030609928     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199705000-00014     Document Type: Article

References (25)

1. Duckrow RB (1991) Regional cerebral blood flow during spreading cortical depression in conscious rats. J Cereb Blood Flow Metab 11:150-154
2. Glossmann H, Ferry DR (1985) Assay for calcium channels. Methods Enzymol 109:513-550
3. Hakim AM, Hogan MJ (1991) In vivo binding of nimodipine in the brain: I. The effect of focal cerebral ischemia. J Cereb Blood Flow Metab 11:762-770
4. + during spreading depression. Acta Physiol Scand 109:1-6
5. Hartigan JA, Wong MA (1979) A K-means clustering algorithm: algorithm 136. Appl Statist 28:100-108
6. Herrera DG, Robertson HA (1990) Application of potassium chloride to the brain surface induces the c-fos proto-oncogene: reversal by MK-801. Brain Res 510:166-170
7. Hogan MJ, Gjedde A, Hakim AM (1991) In vivo binding of nimodipine in the brain: II. Binding kinetics in focal cerebral ischemia. J Cereb Blood Flow Metab 11:771-778
8. Hogan MJ, Hakim AM (1992) Reversibility of nimodipine binding to brain in transient cerebral ischemia. J Neurochem 59:1745-1752
9. Jing J, Aitken PG, Somjen GC (1993) Role of calcium channels in spreading depression in rat hippocampal slices. Brain Res 604: 251-259
10. Kawahara N, Reutzler CA, Klatzo I (1994) A delayed effect of spreading depression on brain tissue associated with protection against ischemic neuronal damage. Brain Path 4:509
11. Kokubun S, Prod'hom B, Becker C, Porzig H, Reuter H (1986) Studies on Ca channels in intact cardiac cells: voltage dependent effects and cooperative interactions of dihydropyridine enantiomers. Mol Pharmacol 30:571-584
12. Lassen NA, Perl W (1979) Tracer Kinetic Methods in Medical Physiology. New York, Raven Press,
13. Lauritzen M, Jørgensen MB, Diemer NH, Gjedde A, Hansen AJ (1982) Persistent oligemia of rat cerebral cortex in the wake of spreading depression. Ann Neurol 12:469-474
14. Leao AAP (1944) Spreading depression of activity in the cerebral cortex. J Neurophysiol 7:359-390
15. Matsushima K, Hogan MJ, Hakim AM (1996) Cortical spreading depression protects against subsequent focal cerebral ischemia in rats. J Cereb Blood Flow Metab 16:221-226
16. McLachlan RS (1992) Suppression of spreading depression of Leao in neocortex by an N-methyl-D-aspartate receptor antagonist. Can J Neurol Sci 19:487-491
17. Mies G, Iijima T, Hossmann K-A (1993) Correlation between peri-infarct DC shifts and ischemic neuronal damage in rat. Neuroreport 4:709-711
18. Murphy TH, Worley PF, Baraban JM (1991) L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron 7:625-635
19. Nedergaard M, Hansen AJ (1988) Spreading depression is not associated with neuronal injury in the normal brain. Brain Res 449:395-398
20. 14C]antipyrine. Am J Physiol 234:H59-H66
21. Shockley RP, LaManna JC (1988) Determination of rat cerebral cortical blood volume changes by capillary mean transit time analysis during hypoxia, hypercapnia and hyperventilation. Brain Res 454: 170-178
22. Somjen GG, Aitken PG, Czéh GL, Herreras O, Jing J, Young JN (1992) Mechanisms of spreading depression: a review of recent findings and a hypothesis. Can J Physiol Pharmacol 70:S248-S254
23. 3H]nimodipine in rat brain after transient forebrain ischemia. J Cereb Blood Flow Metab 14:397-405
24. Triggle DJ, Rampe D (1989) 1,4-Dihydropyridine activators and antagonists: structural and functional distinctions. TIPS 10:507-511
25. Van den Kerckhoff W, Drewes LR (1985) Transfer of the Ca-antagonists nifedipine and nimodipine across the blood-brain barrier and their regional distribution in vivo. J Cereb Blood Flow Metab 5(suppl 1):S459-S460