Plasmodium falciparum asparagine and aspartate rich protein 2 is an evolutionary conserved protein whose repeats identify a new family of parasite antigens

Molecular and Biochemical Parasitology

Volumn 87, Issue 2, 1997, Pages 169-181

  Barale, Jean Christophe ^a   Attal Bonnefoy, Géraldine ^a   Brahimi, Karima ^a   Da Silva, Luiz Pereira ^a   Langsley, Gordon ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

Antigen; Conserved; Gene family; Malaria; Plasmodium falciparum

Indexed keywords

AARP2 PROTEIN, PLASMODIUM FALCIPARUM; COMPLEMENTARY DNA; PARASITE ANTIGEN; PRIMER DNA; PROTOZOAL DNA; PROTOZOAL PROTEIN; ASPARAGINE; ASPARTIC ACID;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; GENE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; ANIMAL EXPERIMENT; CHROMOSOME 1; CONTROLLED STUDY; EVOLUTION; GENE SEQUENCE; IMMUNOFLUORESCENCE; MALARIA; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, PROTOZOAN; BASE SEQUENCE; CONSERVED SEQUENCE; DNA PRIMERS; DNA, COMPLEMENTARY; DNA, PROTOZOAN; EVOLUTION, MOLECULAR; GENE EXPRESSION; GENES, PROTOZOAN; HUMANS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PROTOZOAN PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0030609905     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0166-6851(97)00065-0     Document Type: Article

References (21)

1. Cohen S, McGregor IA, Carrington S. Gamma-globulin and acquired immunity to human malaria. Nature 1961;192:733-7.
2. Gysin J, Dubois P, Pereira da Silva L. Protective antibodies against erythrocytic stages of Plasmodium falciparum in experimental infection of the squirrel monkey Saimiri sciureus. Parasite Immunol 1982;4:421-30.
3. Sabchareon A, Burnouf T, Ouattara D, Attanath P, Bouharoun-Tayoun H, Chanthavanich P, Chongsuphajaisiddhi T, Druilhe P. Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria. Am J Trop Med Hyg 1991;45:297-308.
4. Michel JC, Fandeur T, Neuilly G, Roussilhon C, Dedet JP. Opsonic activity of ascidic fluids from Plasmodium falciparum-infected Saimiri monkeys: positive correlation with protection in passive transfer assay. Ann Inst Pasteur/Immunol 1983;134D:373-83.
5. Groux H, Gysin J. Opsonization as an effector mechanism in human protection against asexual blood stages of Plasmodium falciparum: functional role of IgG subclasses. Res Immunol 1990;141:529-42.
6. Bouharoun-Tayoun H, Attanath P, Sabchareon A, Chongsuphajaisiddhi T, Druilhe P. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J Exp Med 1990;172:1633-41.
7. Bouharoun-Tayoun H, Oeuvray C, Lunel F, Druilhe P. Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. J Exp Med 1995;182:409-18.
8. Gysin J, Gavoille S, Mattei D, Scherf A, Bonnefoy S, Mercereau-Puijalon O, Feldmann T, Müller-Hill B, Pereira da Silva L. In vitro phagocytosis inhibition assay for the screening of potential candidate antigens for subunit vaccines against the asexual blood stage of Plasmodium falciparum. J Immunol Methods 1993;159:209-19.
9. Stahl HD, Bianco AE, Crewther PE, Burkot TR, Coppel RL, Brown GV, Anders RF, Kemp DJ. An asparagine-rich protein from blood stages of Plasmodium falciparum shares determinants with sporozoites. Nucleic Acids Res 1986;7:3089-102.
10. Wahlgren M, Aslund L, Franzén L, Sundvall M, WŠhlin B, Berzins K, McNicol LA, Bjšrkman A, Wigzell H, Perlmann P, Petersson U. A Plasmodium falciparum antigen containing clusters of asparagine residues. Proc Natl Acad Sci USA 1986;83:2677-81.
11. Franzén L, Wahlin B, Wahlgren M, Aslund L, Perlmann P, Wigzell H, Petersson U. Enhancement or inhibition of Plasmodium falciparum erythrocyte reinvasion in vitro by antibodies to an asparagine rich protein. Mol Biochem Parasitol 1989;32:201-12.
12. Baruch DI, Pasloske BL, Singh HB, Bi X, Ma XC, Feldman M, Taraschi TF, Howard RJ. Cloning the P. falciparum gene encoding Pf-EMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell 1995;82:77-87.
13. Peterson DS, Miller LH, Wellems TE. Isolation of multiple sequences from the Plasmodium falciparum genome that encode conserved domains homologous to those in erythrocyte-binding proteins. Proc Natl Acad Sci USA 1995;92:7100-4.
14. Su XZ, Heatwole VM, Wertheimer SP, Guinet F, Herrfeldt JA, Peterson DS, Ravetch JA, Wellems TE. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell 1995;82:89-100.
15. Pologe LG, Pavlovec A, Shio H, Ravetch JV. Primary structure and subcellular localization of the knob-associated histidine rich protein of Plasmodium falciparum. Proc Natl Acad Sci USA 1987;84:7139-43.
16. Pasloske BL, Baruch DI, Van Schravendijk MR, Handunnetti SM, Aikawa M, Fujioka H, Taraschi TF, Gormley JA, Howard RJ. Cloning and characterization of a Plasmodium falciparum gene encoding a novel high-molecular weight host membrane-associated protein, Pf-EMP3. Mol Biochem Parasitol 1993;59:59-72.
17. Cowman AF, Coppel RL, Saint RB, Favaloro JM, Crewther PE, Stahl HD, Bianco AE, Brown GV, Anders RF, Kemp DJ. The ring-infected erythrocyte surface antigen (RESA) polypeptide of Plasmodium falciparum contains two separate blocks of tandem repeats encoding antigenic epitopes that are naturally immunogenic in man. Mol Biol Med 1984;2:207-21.
18. Mattei D, Hinterberg K, Scherf A. Pf-11-1 and Pf-332: two giant proteins synthesized in erythrocytes infected with Plasmodium falciparum. Parasitol Today 1992;8:426-8.
19. Coppel RL, Culvenor JG, Bianco AE, Crewther PE, Stahl HD, Brown GV, Anders RF, Kemp DJ. Variable antigen associated with the surface of erythrocytes infected with mature stages of Plasmodium falciparum. Mol Biochem Parasitol 1986;20:265-77.
20. Carcy B, Bonnefoy S, Guillotte M, Le Scanf C, Grellier P, Schrevel J, Fandeur T, Mercereau-Puijalon O. A large multigene family expressed during the erythrocytic schizogony of Plasmodium falciparum. Mol Biochem Parasitol 1994;68:221-33.
21. Foley M, Corcoran L, Tilley L, Anders R. Plasmodium falciparum: Mapping the membrane-binding domain in the ring-infected erythrocyte surface antigen. Mol Biochem Parasitol 1994;79:340-50.