Heterozygous C8β complement deficiency does not predispose to meningococcal disease

Clinical and Experimental Immunology

Volumn 108, Issue 3, 1997, Pages 497-499

  Platonov, A E ^a   Shipulin, G A ^a   Shipulina, O Ju ^a   Vershinina, I V ^a   Densen, P ^b  

^a Central Research Institute of Epidemiology   (Russian Federation)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

complement deficiency; meningococcal disease

Indexed keywords

COMPLEMENT COMPONENT C8B; COMPLEMENT COMPONENT C8;

ARTICLE; CLINICAL ARTICLE; COMPLEMENT DEFICIENCY; DISEASE PREDISPOSITION; FEMALE; HUMAN; INFECTION RISK; MALE; MENINGOCOCCOSIS; PRIORITY JOURNAL; RISK ASSESSMENT; RUSSIAN FEDERATION; STOP CODON; GENETICS; HETEROZYGOTE;

COMPLEMENT C8; FEMALE; HETEROZYGOTE; HUMANS; MALE; MENINGOCOCCAL INFECTIONS;

EID: 0030609850     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.3711263.x     Document Type: Article

References (11)

1. Ross SC, Densen P. Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency. Medicine (Baltimore) 1984; 63:243-73.
2. Figueroa JE, Densen P. Infectious diseases associated with complement deficiencies. Clin Microbiol Rev 1991; 4:359-95.
3. Platonov AE, Beloborodov VB, Vershinina IV. Meningococcal disease in patients with late complement component deficiency: studies in the USSR. Medicine (Baltimore) 1993; 72:374-92.
4. Saucedo L, Ackermann L, Platonov AE, Gewurz A, Rakita R, Densen P. Delineation of additional genetic bases for C8β deficiency: prevalence of null alleles and predominance of C→T exchange in their genesis. J Immunol 1995; 155:5022-8.
5. Kaufmann TG, Hänsch G, Rittner C, Späth P, Tedesco F, Schneider PM. Genetic basis of human complement C8β deficiency. J Immunol 1993; 150:4943-7.
6. Altman DG. Practical statistics for medical research. London: Chapman and Hall, 1991.
7. Inai S, Akagaki Y, Moriyama T, Fukumori Y, Yoshimura K, Ohnoki S, Yamaguchi H. Inherited deficiencies of the late-acting complement components other than C9 found among healthy blood donors. Int Arch Allergy Appl Immunol 1989; 90:274-9.
8. Taylor PW. Bactericidal and bacteriolytic activity of serum against Gram-negative bacteria. Microbiol Rev 1983; 47:46-83.
9. Schlesinger M, Greenberg R, Levy J, Käyhty H, Levy R. Killing of meningococci by neutrophils: effect of vaccination on patients with complement deficiency. J Infect Dis 1994; 170:449-53.
10. Andreoni J, Käyhty H, Densen P. Vaccination and the role of capsular polysaccharide antibody in prevention of recurrent meningococcal disease in late complement component-deficient individuals. J Infect Dis 1993; 168:227-31.
11. Platonov AE, Vershinina IV, Dolgopolova AJ, Dankert J, Fijen CAP, Käyhty H. Bactericidal effect of human neutrophils on meningococci incubated in pre- and post-vaccination serum of complement deficient patients. In: Zollinger WD, Frasch CE, Deal CD, eds. Pathogenic neisseria. Abstracts of the Tenth International Pathogenic Neisseria Conference. Baltimore, 1996:178-9.