Evidence for Y1 and Y2 subtypes of neuropeptide Y receptors linked to opposing postjunctional effects observed in rat cardiac myocytes

European Journal of Pharmacology

Volumn 336, Issue 2-3, 1997, Pages 257-265

  McDermott, Barbara J ^a   Millar, B Cherie ^a   Dolan, Fiona M ^a   Bell, David ^a   Balasubramaniam, Ambikaipakan ^b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Cardiomyocyte; Contraction; Neuropeptide Y; Receptor subtype

Indexed keywords

NEUROPEPTIDE Y DERIVATIVE; NEUROPEPTIDE Y RECEPTOR; PEPTIDE YY; RECEPTOR SUBTYPE; DRUG DERIVATIVE; NEUROPEPTIDE Y;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HEART MUSCLE CELL; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; HEART; HEART MUSCLE; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; HEART; MALE; MYOCARDIUM; NEUROPEPTIDE Y; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROPEPTIDE Y;

EID: 0030609133     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01258-2     Document Type: Article

References (46)

1. Balasubramaniam A., Sheriff S. Neuropeptide Y (18-36) is a competitive antagonist of neuropeptide Y in rat cardiac ventricular membranes. J. Biol. Chem. 265:1990;14724.
2. Balasubramaniam A., Sheriff S., Rigel D.F., Fischer J.E. Characterization of neuropeptide Y binding sites in rat cardiac ventricular membranes. Peptides. 11:1990;545.
3. 34] neuropeptide Y-(31-36)}: a specific NPY Y-1 antagonist. J. Med. Chem. 39:1996;811.
4. Bard J.A., Walker M.V., Branchek T.A., Weinshank R.L. Cloning and functional expression of a human Y4 subtype receptor for pancreatic-polypeptide, neuropeptide-Y, and peptide YY. J. Biol. Chem. 270:1995;26762.
5. 3 receptor subtype. Mol. Brain Res. 26:1994;320.
6. Entzeroth M., Braunger H., Eberlin W., Engel W., Rudolf K., Wienen W., Wieland H.A., Willim K.D., Doods H.N. Labeling of neuropeptide-Y receptors in SK-N-MC cells using the novel, nonpeptide Y-1 receptor-selective antagonist [H-3] BIBP3226. Eur. J. Pharmacol. 278:1995;239.
7. 1 receptor agonist. Proc. Natl. Acad. Sci. USA. 187:1990;182.
8. Gehlert D.R., Schober D.A., Gackenheimer S.L., Beavers L., Gadski R., Lundell I., Larhammar D. [I-125]Leu(31), Pro(34)-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: Evidence for heterogeneity in pancreatic polypeptide receptors. Peptides. 8:1997;397.
9. Gerald C., Walker M.W., Criscione L., Gustafson E.L., Batzlhartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., Taber R.I., Branchek T.A., Weinshank R.L. A receptor subtype involved in neuropeptide-y-induced food-intake. Nature. 382:1996;168.
10. Giles W., Van Ginneken A. Identification of a transient outward current in single myocytes from crista terminalis of rabbit heart. J. Physiol. Lond. 368:1985;243.
11. 2 selective agonist and a major molecular form of PYY in circulating blood in man. Gastroenterology. 102:1992;A743.
12. Gregor P., Millham M.L., Feng Y., DeCarr L.B., McCaleb M.L., Cornfield L.J. Cloning and characterization of a novel receptor to pancreatic-polypeptide, a member of the neuropeptide-y receptor family. FEBS Lett. 381:1996;58.
13. Grundemar L., Håkanson R. Effects of various neuropeptide Y/peptide YY fragments on electrically-evoked contractions of the rat vas deferens. Br. J. Pharmacol. 100:1990;190.
14. Grundemar L., Jonas S.E., Morner N., Hogestatt E.D., Wahlestedt C., Håkanson R. Characterization of vascular neuropeptide-Y receptors. Br. J. Pharmacol. 105:1992;45.
15. Hegde S.S., Bonhaus D.W., Stanley W., Eglen R.M., Moy T.M., Loeb M., Shetty S.G., Desouza A., Krstenansky J. Pharmacological evaluation of 1229U91, a novel high affinity and selective neuropeptide Y Y-1 receptor antagonist. J. Pharmacol. Exp. Ther. 275:1995;1261.
16. Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. Natl. Acad. Sci. USA. 89:1992;5794.
17. Hu Y.H., Bloomquist B.T., Cornfield L.J., DeCarr L.B., Floresriveros J.R., Friedman L., Jiang P.L., Lewishiggins L., Sadlowski Y., Schaefer J., Velazquez N., McCaleb M.L. Identification of a novel hypothalamic neuropeptide-Y receptor associated with feeding-behavior. J. Biol. Chem. 271:1996;26315.
18. Jacques D., Cadieux A., Dumont Y., Quirion R. Apparent affinity and potency of BIBP3226, a nonpeptide neuropeptide Y receptor antagonist, on purported neuropeptide Y Y-1, Y-2 and Y-3 receptors. Eur. J. Pharmacol. 278:1995;R3.
19. 1 type. J. Biol. Chem. 267:1992;10935.
20. + channels in a human neuroblastoma cell-line. Pflug. Arch. Eur. J. Physiol. 430:1995;534.
21. Lundberg J.M., Hemsen A., Larsson O., Rudehill A., Saria A., Fredholm B. Neuropeptide Y receptor in pig spleen: Binding characteristics, reduction of cyclic AMP formation and calcium antagonist inhibition of vasoconstriction. Eur. J. Pharmacol. 145:1988;21.
22. Lynch J.W., Lemos V.S., Bucher B., Stoclet J.C., Takeda K. Pertussis toxin-insensitive calcium influx mediated by neuropeptide Y-2 receptors in a human neuroblastoma cell-line. J. Biol. Chem. 269:1994;8226.
23. McAuley M.A., Westfall T.C. Possible location and function of neuropeptide Y receptor subtypes in the rat mesenteric arterial bed. J. Pharmacol. Exp. Ther. 261:1992;863.
24. McCloskey D.I., Potter E.K. Neuropeptide Y and cardiovascular regulation. Clin. Exp. Pharmacol. Physiol. 18:1991;47.
25. McDermott B.J., Millar B.C., Piper H.M. Cardiovascular effects of neuropeptide Y: Receptor interactions and cellular mechanisms. Cardiovasc. Res. 27:1993;893.
26. Michel M.C. Receptors for neuropeptide Y: Multiple subtypes and multiple second messengers. Trends Pharmacol. Sci. 12:1991;389.
27. Michel M.C., Schlicker E., Fink K., Boublick J.H., Gothert M., Willette R.N., Daly RN R.N., Hieble J.P., Rivier J.E., Motulsky H.J. Distinction of NPY receptors in vitro and in vivo. NPY(18-36) discriminates NPY receptor subtypes in vitro. Am. J. Physiol. 259:1990;E131.
28. 2+. Biochem. Int. 22:1990;205.
29. Millar B.C., Piper H.M., McDermott B.J. The antiadrenergic effect of neuropeptide Y on the ventricular cardiomyocyte. Naunyn-Schmiedberg's Arch. Pharmacol. 338:1988;426.
30. Millar B.C., Weis T., Piper H.M., Weber M., Bochard U., McDermott B.J., Balasubramaniam A. Positive and negative contractile effects of neuropeptide Y on ventricular cardiomyocytes. Am. J. Physiol. 261:1991;H1727.
31. Millar B.C., McDermott B.J., Balasubramaniam A. NPY(17-36) - A partial agonist at cardiac NPY receptors. J. Mol. Cell. Cardiol. 24:1992;S5.
32. Myers A.K., Farhat M.Y., Shen G.H., Debinski W., Wahlestedt C., Zukowska-Grojec Z. Platelets as a source and site of action for neuropeptide Y. Ann. N.Y. Acad. Sci. 611:1990;408.
33. Nakamura M., Sakanaka C., Aoki Y., Ogasawara H., Tsuji T., Kodama H., Matsumoto T., Shimizu T., Noma M. Identification of 2 isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing-isolation, genomic structure, and functional expression of the receptors. J. Biol. Chem. 270:1995;30102.
34. Piper H.M., Probst I., Schwartz P., Hütter J.F., Spieckermann P.G. Culturing of calcium stable adult cardiac myocytes. J. Mol. Cell. Cardiol. 14:1982;397.
35. Piper H.M., Millar B.C., McDermott B.J. The negative inotropic effect of neuropeptide Y on the ventricular cardiomyocyte. Naunyn-Schmiedberg's Arch. Pharmacol. 340:1989;333.
36. Playford R.J., Cox H.M. Peptide YY and neuropeptide Y: Two peptides intimately involved in electrolyte homeostasis. Trends Pharmacol. Sci. 17:1996;436.
37. 34]NPY, a selective functional postjunctional agonist at neuropeptide-Y receptors in anaesthetised rats. Neurosci. Lett. 134:1992;183.
38. Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M. Cloning and functional expression of a cDNA-encoding a human type-2 neuropeptide-Y receptor. J. Biol. Chem. 270:1995;22661.
39. Rovati G.E., Nicosia S. Lower efficacy: Interaction with an inhibitory receptor or partial agonism. Trends Pharmacol. Sci. 15:1994;140.
40. Rudolf K., Eberlein W., Engel W., Wieland H.A., Willim K.D., Entzeroth M., Wienen W., Becksickinger A.G., Doods H.N. The first highly potent and selective nonpeptide neuropeptide-Y Y-1 receptor antagonist - BIBP3226. Eur. J. Pharmacol. 278:1994;R3.
41. Shen G.H., Grundemar L., Zukowskagrojec Z., Hakanson R., Wahlestedt C. C-terminal neuropeptide-Y fragments are mast cell-dependent vasodepressor agents. Eur. J. Pharmacol. 204:1991;249.
42. Shigeri Y., Mihara S., Fujimoto M. Neuropeptide Y receptor in smooth muscle. J. Neurochem. 56:1991;852.
43. Wahlestedt C., Regunathan S., Reis D.J. Identification of cultured cells selectively expressing Y1-, Y2 or Y-3 type receptors for neuropeptide Y/peptide YY. Life Sci. 50:1992;PL7.
44. Wan C.P., Lau B.H.S. Neuropeptide Y receptor subtypes. Life Sci. 56:1995;1055.
45. Winer, B.J., 1971. Statistical Principles in Experimental Design. McGraw-Hill, New York, p. 201.
46. Xiang H., Brown J.C. Inhibitory effect of neuropeptide-Y and its analogs on inositol 4,5-trisphosphate level in rat cardiomyocytes. Recept. Channels. 1:1993;315.