Effects of dihydropyridine Ca2+ channel blockers on the discriminative stimulus and the motor impairing effects of (±)-Bay K 8644

European Journal of Pharmacology

Volumn 336, Issue 2-3, 1997, Pages 113-121

  Cohen, Caroline ^a   Perrault, Ghislaine ^a   Sanger, David J ^a  

^a SANOFI   (France)

Author keywords

Ca2+ channel; Dihydropyridine; Drug discrimination; Motor effect

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; AMPHETAMINE; APOMORPHINE; CALCIUM CHANNEL BLOCKING AGENT; COCAINE; FLUOXETINE; ISRADIPINE; NICARDIPINE; NICOTINE; NIFEDIPINE; NIMODIPINE; NITRENDIPINE; OXOTREMORINE; PHYSOSTIGMINE; VERAPAMIL; CALCIUM CHANNEL STIMULATING AGENT;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOSE RESPONSE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TRAINING; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; MOTOR ACTIVITY; PERCEPTIVE DISCRIMINATION;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; DISCRIMINATION (PSYCHOLOGY); MALE; MICE; MOTOR ACTIVITY; NICARDIPINE; NIFEDIPINE; NIMODIPINE;

EID: 0030609132     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01240-5     Document Type: Article

References (37)

1. 2+ channels. Trends Pharmacol. Sci. 9:1988;257-261.
2. Bolger G.T., Weissman B.A., Skolnick P. The behavioral effects of the calcium agonist BAY K 8644 in the mouse: Antagonism by the calcium antagonist nifedipine. Naunyn-Schmiedebergs Arch Pharmacol. 328:1985;373-377.
3. Bourson A., Moser P.C., Gower A.J., Mir A.K. Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat. Eur. J. Pharmacol. 160:1989;339-347.
4. Calcagnetti D.J., Schechter M.D. Isradipine produces neither a conditioned place preference nor aversion. Life Sci. 54:1994;PL81-86.
5. Cohen, C., Perrault, Gh., Sanger, D.J., 1997. Assessment of the antidepressant-like effects of L-type voltage-dependent calcium channel modulators. Behav. Pharmacol., in press.
6. Colpaert, F.C., 1986. Drug discrimination: Behavioral, pharmacological and molecular mechanisms of discriminative drug effects. In: Goldberg, S.R., Stolerman, I.P. (Eds.), Behavioral Analysis of Drug Dependence. Academic Press, New York, p. 161-193.
7. De Beun R., Lohmann A., Schneider R., Jentzsch K., De Vry J. Affective and discriminative stimulus properties of the calcium channel blocker nimodipine in rats. Behav. Pharmacol. 5:1994;112.
8. De Beun R., Schneider R., Klein A., Lohmann A., de Vry J. Effects of nimodipine and other calcium channel antagonists in alcohol-preferring AA rats. Alcohol. 13:1996;263-271.
9. De Beun R., Lohmann A., De Vry J. Conditioned taste aversion and place preference induced by the calcium channel antagonist nimodipine in rats. Pharmacol. Biochem. Behav. 54:1996;657-663.
10. De Beun R., Lohmann A., Kuhl E., Dalmus M., Schreiber R., De Vry J. Stimulus properties of the L-type calcium channel agonist BAY K 8644 in rats. Behav. Pharmacol. 7:1996;346-354.
11. De Vry J., Schreiber R., De Beun R. Stimulus properties of (-)BAY K 8644, a calcium channel agonist: Comparison with the calcium channel antagonist nimodipine. Behav. Pharmacol. 7:1996;29.
12. Dube G.P., Baik Y.H., Vaghy P.L., Schwartz A. Nitrendipine potentiates BAY K 8644-induced contraction of isolated porcine coronary artery: Evidence for functionally distinct dihydropyridine receptor subtypes. Biochem. Biophys. Res. Commun. 128:1985;1295-1302.
13. Ferry D.R., Glossman H. Evidence for multiple receptor sites within the putative calcium channel. Naunyn-Schmiedebergs Arch. Pharmacol. 321:1982;80-83.
14. Ferry D.R., Goll A., Gadow C., Glossman H. (-)-3H-desmethoxyverapamil labeling of putative calcium channels in brain: Autoradiographic distribution and allosteric coupling to 1,4-dihydropyridine and diltiazem binding sites. Naunyn-Schmiedebergs Arch. Pharmacol. 327:1984;183-187.
15. Forti L., Pietrobon D. Functional diversity of L-type calcium channels in rat cerebellar neurons. Neuron. 10:1993;437-450.
16. Gladstein L., Traber J., Spencer D.G. Jr. Preliminary analysis of the discriminative stimuli induced by the calcium channel 'agonist' BAY K 8644. Drug Develop. Res. 11:1987;59-64.
17. Janis R.A., Silver P.J., Triggle D.J. Drug action and cellular calcium regulation. Adv. Drug Res. 16:1987;309-591.
18. Kokubun S., Prod'hom B., Becker C., Porzig H., Reuter H. Studies on Ca channels in intact cardiac cells: Voltage-dependent effects and cooperative interactions of dihydropyridine enantiomers. J. Pharmacol. Exp. Ther. 30:1986;571-584.
19. Lee H.R., Roeske W.R., Yamamura H.I. High affinity specific [3H](+)PN 200-110 binding to dihydropyridine receptors associated with calcium channels in rat cerebral cortex and heart. Life Sci. 35:1984;721-732.
20. +-evoked efflux of acetylcholine and noradrenaline from rat brain slices. Naunyn-Schmiedebergs Arch. Pharmacol. 331:1985;114-116.
21. Middlemiss D.N., Spedding M. A functional correlate for the dihydropyridine binding site in rat brain. Nature. 314:1985;94-96.
22. Mogilnicka E., Czyrak A., Maj J. Dihydropyridine calcium channel antagonists reduce immobility in the mouse behavioral despair test: Antidepressants facilitate nifedipine action. Eur. J. Pharmacol. 138:1987;413-416.
23. O'Neill S.K., Bolger G.T. Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Res. Bull. 21:1988;865-872.
24. Palmer G.C., Stagnitto M.L., Ray R.K., Knowles M.A., Harvey R., Garske G.E. Anticonvulsant properties of calcium channel blockers in mice: N-Methyl-D-,L-Aspartate- and Bay K 8644-induced convulsions are potently blocked by the dihydropyridines. Epilepsia. 34:1993;372-380.
25. Petersen E.N. Bay K 8644 induces a reversible spasticity-like syndrome in rats. Eur. J. Pharmacol. 130:1986;323-326.
26. Porzig H., Becker C. Potential-dependent allosteric modulation of 1,4-dihydropyridine binding by D-(cis)-diltiazem and (±)-verapamil in living cardiac cells. Mol. Pharmacol. 34:1988;172-179.
27. Pucilowski O. Psychopharmacological properties of calcium channel inhibitors. Psychopharmacology. 109:1992;12-29.
28. Rosenzweig-Lipson S., Barrett J.E. Modification of the behavioral effects of (±)Bay K 8644, cocaine and D-amphetamine by L-type calcium channel blockers in squirrel monkeys. J. Pharmacol. Exp. Ther. 274:1995;842-851.
29. Schechter M.D. Discriminative stimulus properties of isradipine: Effect of other calcium channel blockers. Pharmacol. Biochem. Behav. 50:1995;539-543.
30. 3H ]-diltiazem binding to calcium channel antagonists recognition sites in rat cerebral cortex Eur. J. Pharmacol. 111:1985;273-277.
31. Spedding M., Paoletti R. III. Classification of calcium channels and the sites of action of drugs modifying channel function. Pharmacol. Rev. 44:1992;363-376.
32. Triggle D.J., Rampe D. 1,4-Dihydropyridine activators and antagonists: Structural and functional distinctions. Trends Pharmacol. Sci. 10:1989;507-511.
33. Usowicz M.M., Gigg M., Jones L.M.E., Cheung C.W., Hartley S.A. Allosteric interactions at L-type calcium channels between FPL 64176 and the enantiomers of the dihydropyridine Bay K 8644. J. Pharmacol. Exp. Ther. 275:1995;638-645.
34. Vanhoutte P.M., Paoletti R. The WHO classification of calcium antagonists. Trends Pharmacol. Sci. 8:1987;4-5.
35. Watson W.P., Little H.J. Effects of diltiazem in convulsive states differ from those previously reported for dihydropyridine calcium channel antagonists. Psychopharmacology. 114:1994;321-328.
36. 2+ channel antagonists and activators in cultured neonatal rat ventricular myocytes. Mol. Pharmacol. 35:1989;541-552.
37. Woodward J.J., Leslie S.W. BAY K 8644 stimulation of calcium entry and endogenous dopamine release in rat striatal synaptosomes antagonized by nimodipine. Brain Res. 370:1986;397-400.