Adding Zn2+ induces DNA fragmentation and cell condensation in cultured human Chang liver cells

Biological Trace Element Research

Volumn 58, Issue 1-2, 1997, Pages 135-147

  Paramanantham, Ramanujam ^a   Sit, Kwok Hung ^a   Bay, Boon Huat ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cell condensation and rounding; DNA fragmentation; Enhanced toxicity from reactive oxygen species; Glutathione; Micrococcal nuclease; Programmed cell death; Terminal deoxynucleotidyl transferase mediated end labeling of DNA nicks

Indexed keywords

DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; FREE RADICAL; GLUTATHIONE; HYDROXYL RADICAL; ZINC; CHLORIDE; DEOXYURIDINE PHOSPHATE; DEOXYURIDINE TRIPHOSPHATE; DNA FRAGMENT; MICROCOCCAL NUCLEASE; VANADIC ACID; ZINC CHLORIDE; ZINC DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DEGRADATION; DNA SYNTHESIS; HAIR LOSS; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; WEIGHT REDUCTION; ZINC DEFICIENCY; CELL CULTURE; CELL CYCLE; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; FLOW CYTOMETRY; LIVER; METABOLISM; PHASE CONTRAST MICROSCOPY;

APOPTOSIS; CELL CYCLE; CELLS, CULTURED; CHLORIDES; CULTURE MEDIA, SERUM-FREE; DEOXYURACIL NUCLEOTIDES; DNA; DNA FRAGMENTATION; DNA NUCLEOTIDYLEXOTRANSFERASE; FLOW CYTOMETRY; GLUTATHIONE; HUMANS; HYDROXYL RADICAL; LIVER; MICROCOCCAL NUCLEASE; MICROSCOPY, PHASE-CONTRAST; OXIDATIVE STRESS; VANADATES; ZINC COMPOUNDS;

EID: 0030609078     PISSN: 01634984     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02910674     Document Type: Article

References (5)

1. C. L. Keen and L. S. Hurley, Zinc and reproduction: effects of deficiency on foetal and postnatal development, in Zinc in Human Biology, C. F. Mills, ed., Springer-Verlag, London, pp. 183-220 (1989).
2. N. W. Solomons, Zinc and copper, in Modern Nutrition in Health and Diseases, 7th ed. M. E. Shils and V. R. Young, eds., Lea and Febiger, Philadelphia, pp. 238-262 (1988).
3. R. L. Goldberg, T. Tamura, Y. Neggers, R. L. Copper, K. E. Johnston, M. B. DuBard, and J. C. Hauth, The effect of zinc supplementation of pregnancy outcome, JAMA 274, 463-168 (1995).
4. P. Faure, J. C. Peyrin, M. J. Richard, and A. Favier, Parenteral supplementation with zinc in surgical patients corrects postoperative serum zinc-drop, Biol. Trace Element Res. 30, 37-45 (1991).
5. C. Fons, J. F. Brun, C. Fedou, M. Fussellier, L. Bardet, and A. Orsetti, Effects of zamic as a means for zinc supplementation in growing children, Biol. Trace Element Res. 48, 31-36 (1995).