Processing of [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P in xenograft bearing Nu/Nu mice

Peptides

Volumn 18, Issue 7, 1997, Pages 1073-1077

  Jones, D A ^a   MacLellan, A J ^a   Cummings, J ^a   Ritchie, A A ^a   Langdon, S P ^a   Smyth, J F ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Antitumor; In vivo metabolism; Neuropeptide antagonist; Pharmacokinetics

Indexed keywords

SUBSTANCE P [1 DEXTRO ARGININE 5 DEXTRO PHENYLALANINE 7,9 DEXTRO TRYPTOPHAN 11 LEUCINE]; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; SUBSTANCE P; SUBSTANCE P, PHE(5) TRP(7,9) LEU(11); SUBSTANCE P, PHE(5)-TRP(7,9)-LEU(11)-;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG UPTAKE; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG SMALL CELL CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; CELL CULTURE; HALF LIFE TIME; HUMAN; LUNG TUMOR; METABOLISM; NUDE MOUSE; SMALL CELL CARCINOMA; TISSUE DISTRIBUTION; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, SMALL CELL; FEMALE; HALF-LIFE; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; SUBSTANCE P; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0030608993     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(97)00042-9     Document Type: Article

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