α1-Antichymotrypsin polymorphism in Japanese cases of Alzheimer's disease

Journal of the Neurological Sciences

Volumn 152, Issue 2, 1997, Pages 136-139

  Yoshizawa, Toshihiro ^a   Yamakawa Kobayashi, Kimiko ^a   Hamaguchi, Hideo ^a   Shoji, Shin'ichi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

1 Antichymotrypsin polymorphism; Allele frequency; Alzheimer's disease; Apolipoprotein E polymorphism; Genotype distribution; Odds ratio

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; APOLIPOPROTEIN E4; APOLIPOPROTEIN E; ENDODEOXYRIBONUCLEASE BSTNI; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; DISEASE PREDISPOSITION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RISK ASSESSMENT; FEMALE; GENE FREQUENCY; GENETICS; GENOTYPE; HETEROZYGOTE DETECTION; JAPAN; MALE; MIDDLE AGED; REFERENCE VALUE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK;

AGED; AGED, 80 AND OVER; ALPHA 1-ANTICHYMOTRYPSIN; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; FEMALE; GENE FREQUENCY; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; JAPAN; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REFERENCE VALUES;

EID: 0030608901     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(97)00162-7     Document Type: Article

References (12)

1. Abraham, C.R., Selkoe, D.J., Potter, H., 1988. Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell 52, 487-501.
2. Corder, E.H., Saunders, A.M., Strittmatter, W.J., Schmechel, D.K., Gaskell, P.C., Small, G.W., Roses, A.D., Haines, J.L., Pericak-Vance, M.A., 1993. Apolipoprotein E4 gene dose and the risk of Alzheimer disease in late onset families. Science 261, 921-923.
3. Faber, J.-P., Poller, W., Olek, K., Baumann, U., Carlson, J., Lindmark, B., Eriksson, S., 1993. The molecular basis of α1-antichymotrypsin deficiency in a heterozygote with liver and lung disease. J. Hepatol. 18, 313-321.
4. Haines, J.L., Pritchard, M.L., Saunders, A.M., Schildkraut, J.M., Growdon, J.H., Gaskell, P.C., Farrer, L.A., Auerbach, S.A., Gusella, J.F., Locke, P.A., Rosi, B.L., Yamaoka, L., Small, G.W., Conneally, P.M., Roses, A.D., Pricak-Vance, M.A., 1996. No genetic effect of α1-antichymotrypsin in Alzheimer disease. Genomics 33, 53-56.
5. Kamboh, M.I., Sanghera, D.K., Ferrell, R.E., DeKosky, S.T., 1995. APO*E4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism. Nature Gen. 10, 486-488.
6. Ma, J., Yee, A., Brewer, Jr. H.B., Das, S., Potter, H., 1994. Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature 372, 92-94.
7. McKhann, G., Drachmann, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M., 1984. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
8. Nacmias, B., Tedde, A., Latorraca, S., Piacentini, S., Bracco, L., Amaducci, L., Guarnieri, B.M., Petruzzi, C., Ortenzi, L., Sorbi, S., 1996. Apolipoprotein E and α1-antichymotrypsin polymorphism in Alzheimer's disease. Ann. Neurol. 40, 678-680.
9. Strittmatter, W.J., Saunders, A.M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G.S., Roses, A.D., 1993. Apolipoprotein E: High avidity binding to β-amyloid and increase frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc. Natl. Acad. Sci. USA 90, 1977-1981.
10. Wenham, P.R., Price, W.H., Blundell, G., 1991. Apolipoprotein genotyping by one-stage PCR. Lancet 337, 1158-1159.
11. 717Va1→Ile substitution in the amyloid precursor protein in Japanese familial and sporadic Alzheimer's disease. J. Neurol. Sci. 117, 12-15.
12. Yoshizawa, T., Yamakawa-Kobayashi, K., Komatsuzaki, Y., Arinami, T., Oguni, E., Mizusawa, H., Shoji, S., Hamaguchi, H., 1994. Dose-dependent association of apolipoprotein E allele ε4 with late-onset, sporadic Alzheimer's disease. Ann. Neurol. 36, 656-659.