Mediation of prostaglandin f(2α)-induced ocular surface hyperemia by sensory nerves in rabbits

Current Eye Research

Volumn 16, Issue 9, 1997, Pages 886-890

  Astin, Maria ^a   Stjernschantz, Johan ^a  

^a Glaucoma Research Laboratories   (Sweden)

Author keywords

Blood flow; Electrocoagulation of trigeminal nerve; Ocular hyperemia; Prostaglandin F(2 ); Rabbit; Sensory denervation

Indexed keywords

MICROSPHERE; PROSTAGLANDIN F2 ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; ELECTROCOAGULATION; EYE BLOOD FLOW; EYE DISEASE; EYELID; FEMALE; HYPEREMIA; INNERVATION; IRIS; ISOTOPE LABELING; MALE; NICTITATING MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCLERA; SENSORY NERVE; TRIGEMINAL NERVE; UVEA; ANIMAL; BLOOD FLOW; CHEMICALLY INDUCED DISORDER; DENERVATION; EYE; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSORY NERVE CELL; VASCULARIZATION;

ANIMALS; DENERVATION; DINOPROST; EYE; FEMALE; HYPEREMIA; MALE; MICROSPHERES; NEURONS, AFFERENT; RABBITS; REGIONAL BLOOD FLOW;

EID: 0030608813     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.16.9.886.5038     Document Type: Article

References (24)

1. Bito, L. Z., Camras, C. B., Gum, G. G. and Resul, B. (1989) The ocular hypotensive effects and side effects of prostaglandins on the eyes of experimental animals. In The Ocular Effects of Prostaglandins and Other Eicosanoids (Eds. Bito, L. Z. and Stjernschantz, J.). Pp. 349-368. Alan R. Liss Inc., New York.
2. 2α and its isopropyl ester on normal and glaucomatous human eyes. In The Ocular Effects of Prostaglandins and Other Eicosanoids (Eds. Bito, L. Z. and Stjernschantz, J.). Pp. 447-458. Alan R. Liss Inc., New York.
3. 2α in the human eye. Graefes Arch. Clin. Exp. Ophthalmol. 222, 139-141.
4. 2 effects on normal human intraocular pressure. J. Ocul. Pharmacol. 4, 13-18.
5. 2 and its analogue, BW245C, on intraocular pressure in humans. Graefes Arch. Clin. Exp. Ophthalmol. 229, 411-413.
6. Stjernschantz, J. and Resul, B. (1992) Phenyl-substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future, 17, 691-704.
7. Resul, B., Stjernschantz, J., No, K., Liljebris, C., Selén, G., Astin, M., Karlsson, M. and Bito, L. Z. (1993) Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. J. Med. Chem. 36, 243-248.
8. Alm, A., Villumsen, J., Törnquist, P., Mandahl, A., Airaksinen, J., Tuulonen, A., Marsk, A., Resul, B. and Stjernschantz, J. (1993) Intraocular pressure-reducing effect of PhXA41 in patients with increased eye pressure: a one-month study. Ophthalmology, 100, 1312-1316.
9. 2α analog, on aqueous humor dynamics in human eyes. Ophthalmology, 100, 1297-1304.
10. Nagasubramanian, S., Sheth, G. P., Hitchings, R. A. and Stjernschantz, J. (1993) Intraocular pressure-reducing effect of PhXA41 in ocular hypertension. Ophthalmology, 100, 1305-1311.
11. 2α analogue. In Advances in Prostaglandin, Thromboxane, and Leukotriene Research (Eds. Samuelsson, B., Ramwell, P. W., Paoletti, R., Folco, G., Granström, E. and Nicosia, S.). Pp. 513-518. Raven Press, New York.
12. Butler, J. M. and Hammond, B. R. (1977) Neurogenic response of the eye to injury. Trans. Ophthalmol. Soc., UK, 97, 668-674.
13. Butler, J. M. and Hammond, B. R. (1980) The effect of sensory denervation on the response of the rabbit eye to prostaglandin E2, bradykinin and substance P. Br. J. Pharmacol. 69, 495-502.
14. Buckberg, G. D., Luck, J. C., Payne, B. D., Hoffman, J. I. E., Archie, J. P. and Fixler, D. E. (1971) Some sources of error in measuring regional blood flow with radioactive microspheres. J. Appl. Physiol. 4, 598-604.
15. Alm, A. and Bill, A. (1972) The oxygen supply to the retina: II. effects of high intraocular pressure and of increased arterial carbon dioxide tension on uveal and retinal blood flow in cats. Acta Physiol. Scand. 84, 306-319.
16. Hillerdal, M., Sperber, G. O. and Bill, A. (1987) The microsphere method for measuring low blood flows: theory and computer simultations applied to findings in the rat cochlea. Acta Physiol. Scand. 130, 229-235.
17. 2α-induced ocular hyperemia. Exp. Eye Res. 59, 401-408.
18. 2α. Br. J. Pharmacol. 78, 560-567.
19. Chen, J., Champa-Rodriguez, M. L., Woodward, D. F. (1995) Identification of a prostanoid FP receptor population producing endothelium-dependent vasorelaxation in the rabbit jugular vein. Br. J. Pharmacol. 116, 3035-3041.
20. Wang, X., Wu, Z., Tang, Y., Fiscus, R. R. and Han, C. (1996) Rapid nitric oxide- and prostaglandin-dependent release of calcitonin gene-related peptide (CGRP) triggered by endotoxin in rat mesenteric arterial bed. Br. J. Pharmacol. 118, 2164-2170.
21. Edvinsson, L., Fredholm, B. B., Hamel, E., Jansen, I. and Verrecchia, C. (1985) Perivascular peptides relax cerebral arteries concomitant with a rise in cAMP or release of an endothelium-derived relaxant factor. Neurosci. Lett. 58, 213-217.
22. Maggi, C. A. (1995) Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog. Neurobiol. 45, 1-98.
23. Holzer, P., Jocic, M. and Peskar, B. A. (1995) Mediation by prostaglandins of the nitric oxide-induced neurogenic vasodilatation in rat skin. Br. J. Pharmacol. 116, 2365-2370.
24. Coleman, R. A., Smith, W. L. and Narumiya, S. (1994) VIII International Union of Pharmacology. Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46, 205-229.