The adenosine A1 receptor antagonist BIIP 20 counteracts scopolamine-induced behavioral deficits in the passive avoidance task in the rat

European Journal of Pharmacology

Volumn 328, Issue 1, 1997, Pages 19-22

  Pitsikas, Nikolaos ^a   Borsini, Franco ^a  

^a Boehringer Ingelheim Italia SpA   (Italy)

Author keywords

Adenosine A1 receptor antagonist; BIIP 20; Memory; Passive avoidance

Indexed keywords

ADENOSINE A1 RECEPTOR ANTAGONIST; BIIP 20; SCOPOLAMINE; UNCLASSIFIED DRUG; ADENOSINE RECEPTOR; KFM 19; MUSCARINIC RECEPTOR BLOCKING AGENT; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; MALE; MEMORY; NONHUMAN; ORAL DRUG ADMINISTRATION; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; ANIMAL; AVOIDANCE BEHAVIOR; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSTIMULATION; INTRAPERITONEAL DRUG ADMINISTRATION; PAIN THRESHOLD; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; AVOIDANCE LEARNING; ELECTRIC STIMULATION; INJECTIONS, INTRAPERITONEAL; MALE; MEMORY; MUSCARINIC ANTAGONISTS; PAIN THRESHOLD; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; SCOPOLAMINE; XANTHINES;

EID: 0030608763     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)83021-X     Document Type: Article

References (12)

1. Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunctions. Science. 217:1982;408.
2. 1A receptor agonist, impairs performance in a passive avoidance task. Eur. J. Pharmacol. 211:1992;227.
3. Cox, D.R., Oakes, D., 1984. Analysis of Survival Data. Chapman and Hall, London.
4. Hollins C., Stone T.W. Adenosine inhibition of GABA release from slices of rat cerebral cortex. Br. J. Pharmacol. 69:1980;107.
5. King R.A., Glasser R.L. Duration of electroconvulsive shock-induced retrograde amnesia in rats. Physiol. Behav. 5:1970;335.
6. 1 receptors. Brain Res. Bull. 27:1991;101.
7. Phillis J.W., Kostopoulos G.K. Adenosine as a putative transmitter in the cerebral cortex. Life Sci. 17:1975;1085.
8. Schignitz G., Kuefner-Muehl U., Ensinger H., Lehr E. Novel xanthine derivative for treatment of cognitive deficits. Biol. Psychiatry. 29:1991;29.
9. 1 receptor agonist and antagonist on spatial learning and memory. Eur. J. Pharmacol. 249:1993;271.
10. 6-(L-phenylisopropyl)-adenosine, caffeine, theophylline and rolipram on the acquisition of conditioned responses in rabbit. J. Pharmacol. Exp. Ther. 241:1987;223.
11. Williams M. Adenosine: the prototypic neuromodulator. Neurochem. Int. 14:1989;249.
12. Zarrindast M.R., Shafaghi B. Effects of adenosine receptor agonists and antagonists on acquisition of passive avoidance learning. Eur. J. Pharmacol. 256:1994;233.