Protective effect of L-2-oxothiazolidine-4-carboxylate treatment on cyclophosphamide-induced cystitis in rats

Journal of Urology

Volumn 157, Issue 5, 1997, Pages 1946-1950

  Safron, J ^a   Rice, D ^b   Gordon, D ^b   Leaf, C ^b   White, R ^b  

^a BAXTER HEALTHCARE CORPORATION   (United States)

^b NONE

Author keywords

cyclophosphamide; cystitis; L 2 oxothiazolidine 4 carboxylate; rat

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; ACROLEIN; CYCLOPHOSPHAMIDE; 2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID; PYROGLUTAMIC ACID; THIAZOLE DERIVATIVE; THIAZOLIDINE DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG METABOLISM; HEMORRHAGIC CYSTITIS; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; ANIMAL; CHEMICALLY INDUCED DISORDER; CYSTITIS; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CYCLOPHOSPHAMIDE; CYSTITIS; MALE; PYRROLIDONECARBOXYLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLES; THIAZOLIDINES;

EID: 0030608761     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)64907-3     Document Type: Article

References (21)

1. ®. Montvale, N.J.: Medical Economics Data, pp. 744-745, 1993.
2. Haskell, M. H.: Drugs used in cancer chemotherapy. In: Cancer Treatment, 3rd edition. Edited by C. M. Haskell. Philadelphia: W.B. Saunders Co., chapt. 5, pp. 44-51, 1990.
3. Calabresi, P. and Chabner, B. A.: Antineoplastic agents. In: Goodman and Gilman's the pharmacological basis of therapeutics, 8th edition. Edited by A. G. Gilman, T. W. Rall, A. S. Nies, and T. Palmer. New York: Pergamon Press, chapt. 52, pp. 1209-1263, 1990.
4. Cox, P. J.: Cyclophosphamide cystitis-identification of acrolein as the causative agent. Biochem. Pharm., 28: 2045, 1979.
5. Themann, H., Oberdorf, E., Brock, N. and Pohl, J.: Electron microscopic investigations of the cyclophosphamide-induced lesions of the urinary bladder of the rat and their prevention by Mesna. Urol. Int., 42: 37, 1987.
6. Habs, M. R. and Schmähl, D.: Prevention of urinary bladder tumors in cyclophosphamide-treated rats by additional medication with the uroprotectors sodium 2-mercaptoethane sulfonate (Mesna) and disodium 2,2′-dithio-bis-ethane sulfonate (Dimesna). Cancer, 51: 606, 1983.
7. Berger, N. A.: Alkylating agents. In: Cancer, Principles & Practice of Oncology, 4th edition. Edited by V. T., DeVita Jr., S. Hellman, and S. A. Rosenberg. Philadelphia: J. B. Lippincott Co., sect. 8, pp. 400-408, 1993.
8. Tedeschi, M., Bohm, S. and Di Re, F.: Glutathione and detoxification. Cancer Treatment Reviews, 17: 201, 1990.
9. Feuer, G.: Glutathione in detoxication. In: Molecular Biochemistry of Human Disease. Boca Raton: CRC Press, Inc., vol. 1, pp. 77-78, 1985.
10. ™, a cysteine prodrug, given once intravenously to neonatal rats. Toxicol. Letters, 69: 15, 1993.
11. White, R. D., Rice, D. W. and Wilson, D. M.: Acute toxicity in neonatal rats, young adult dogs, rats and mice intravenously administered L-2-oxothiazolidine-4-carboxylate. J. Am. Coll. Toxicol. Part B, 1: 164, 1992.
12. Anderson, M. E. and Meister, M.: Marked increase of cystine levels in many regions of the brain after administration of 2-oxothiazolidine-4-carboxylate. FASEB Journal, 3: 1632, 1989.
13. Brock, N., Pohl, J. and Stekar, J.: Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention. Comparative study on the Uroprotective efficacy of thiols and other sulfur compounds. Eur. J. Cancer Clinical Oncology, 17: 1155, 1981.
14. Abacus Concepts, StatView. Abacus Concepts, Inc., Berkeley, CA 1992.
15. 2 alpha for the prophylaxis of cyclophosphamide induced cystitis in rats. J. Urol., 144: 1500, 1990.
16. Freedman, A., Ehrlich, R. M. and Ljung, B.: Prevention of cyclophophamide cystitis with 2-mercaptoethane sodium sulfonate: A histologic study. J. Urol., 132: 580, 1984.
17. ®). Exp. Opin. Invest. Drugs, 3: 1293, 1994.
18. ®. Montvale, N.J.: Medical Economics Data, pp. 749-750, 1993.
19. Meister, A.: New aspects of glutathione biochemistry and transport-selective alteration of glutathione metabolism. Nutrition Reviews, 42: 397, 1984.
20. Klebanoff, S. J.: Oxygen metabolites from phagocytes. In: Inflammation: Basic Principles and Clinical Correlates, 2nd edition. Edited by J. I. Gallin, I. M. Goldstein, and R. Snyderman. New York: Raven Press Ltd., chapt. 28, pp. 541-588, 1992.
21. Williamson, D. M., Boettcher, B. and Meister, A.: Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-1-prolinase substrate. Proc. Natl. Acad. Sci., 79: 6246, 1982.