Expression of L1 in primary astrocytes via a defective herpes simplex virus vector promotes neurite outgrowth and neural cell migration

Molecular Brain Research

Volumn 43, Issue 1-2, 1996, Pages 311-320

  Yazaki, Takahito ^a   Martuza, Robert L ^a   Rabkin, Samuel D ^a,b  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b KEIO UNIVERSITY   (Japan)

Author keywords

Astrocytes; Cerebellar granule cells; Gene therapy; Herpes simplex virus; L1; Neural cell adhesion molecule; Neural regeneration

Indexed keywords

NERVE CELL ADHESION MOLECULE; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL MIGRATION; GRANULE CELL; HERPES SIMPLEX VIRUS; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NEURITE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ASTROCYTES; CELL DIVISION; CELLS, CULTURED; HUMANS; NEURAL CELL ADHESION MOLECULES; NEURITES; RATS; SIMPLEXVIRUS;

ANIMALIA; HERPES; SIMPLEXVIRUS;

EID: 0030608515     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(96)00186-6     Document Type: Article

References (83)

1. Aguayo, A., David, S., Richardson, P. and Bray, G., Axonal elongation in peripheral and central nervous system transplants, Adv. Cell Neurobiol., 3 (1982) 215-234.
2. Asou, H., Miura, M., Kobayashi, M. and Uyemura, K., The cell adhesion molecule L1 has a specific role in neural cell migration, NeuroReport, 3 (1992) 481-484.
3. Ausubel, F.M., Brent R., Kingston, R.E., Moore, D.D., Seidman, I.G., Smith J.A. and Struhl, K. (1991), Current Protocols in Molecular Biology, Wiley-Interscience, New York.
4. Bahr, B.A., Neve, R.L., Sharp, J., Geller, A.I. and Lynch, G., Rapid and stable gene expression in hippocampal slice cultures from a defective HSV-1 vector, Mol. Brain Res., 26 (1994) 277-285.
5. Bahr, M and Bonhoeffer, F., Perspectives on axonal regeneration in the mammalian CNS, Trends Neurosci., 17 (1994) 473-479.
6. Baorto, D.M., Mellado, W. and Shelanski, M.L., Astrocyte process growth induction by actin breakdown, J. Cell Biol., 117 (1992) 357-367.
7. Beck, K.D., Valverde, J., Alexl, T., Poulsen, K., Moffat, B., Vandlen, R.A., Rosenthal, A. and Hefti, F., Mesencephalic dopaminergic neuron protected by GDNF from axotomy-induced degeneration in the adult brain, Nature, 373 (1995) 339-341.
8. Bergold, P.J., Casaccia-Bonnefil, P., Xiu-Liu, Z. and Federoff, H.J., Transynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor, Proc. Natl. Acad. Sci. USA, 90 (1993) 6165-6169.
9. Berry, M., Rees, L., Hall, S., Yiu, P. and Sievers, J., Optic axons regenerate into sciatic nerve isografts only in the presence of Schwann cells, Brain Res. Bull., 20 (1988) 223-231.
10. Bieber, A.J., Snow, P.M., Hortsch, M., Patel, N.H., Jacobs, J.R., Traquina, Z.R., J., S. and Goodman, C.S., Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1, Cell, 59 (1989) 447-460.
11. Bixby, J.L., Lilien, J. and Reichardt, L.F., Identification of the major proteins that promote neuronal process outgrowth on Schwann cells in vitro, J. Cell Biol., 107 (1988) 353-361.
12. Bjorklund, A. and Stenevi, U., Intracerebral neural implants: Neuronal replacement and reconstruction of damaged circuitries, Annu. Rev. Neurosci., 7 (1984) 279-308.
13. Bock, E., Richter-Landsberg, C., Faissner, A. and Schachner, M., Demonstration of immunochemical identity between the nerve growth factor-induced large external (NILE) glycoprotein and the cell adhesion molecule L1, EMBO J., 4 (1985) 2765-2768.
14. Burgoon, M.P., Grumet, M., Mauro, V., Edelman, G.M. and Cunningham, B.A., Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamily, J. Cell Biol., 112 (1991) 1017-1029.
15. Burgoyne, R.D. and Cambray-Deakin, M.A., The cellular neurobiology of neuronal development: the cerebellar granule cell, Brain Res. Rev., 13 (1988) 77-101.
16. Chuong, C.-M., Crossin, K.L. and Edelman, G.M., Sequential expression and differential function of multiple adhesion molecules during the formation of cerebellar cortical layer, J. Cell Biol., 104 (1987) 331-342.
17. Davison, M.-J., Preston, V.G., and McGeoch, D.J., Determination of the sequence alteration in the DNA of the herpes simplex virus type 1 temperature-sensitive mutant tsK, J. Gen. Virol., 65 (1984) 859-863.
18. Doherty, P., Williams, E. and Walsh, F.K., A soluble chimeric form of the L1 glycoprotein stimulates neurite outgrowth, Neuron, 14 (1995) 57-66.
19. During, M.J., Naegele, J.R., O'Malley, K.L. and Geller, A.I., Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase, Science, 226 (1994) 1399-1403.
20. Edelman, G.M., Cell adhesion and the molecular processes of morphogenesis, Annu. Rev. Biochem., 54 (1985) 135-169.
21. Federoff, H.J., Geschwind, M.D., Geller, A.I. and Kessler, J.A., Expression of NGF in vivo, from a defective HSV-1 vector, prevents effects of axotonomy on sympathetic ganglia, Proc. Natl. Acad. Sci. USA, 89 (1992) 1636-1640.
22. Felsenfeld, D.P., Hynes, M.A., Skoler,K.M., Furley, A.J., and Jessel, T.M., TAG-1 can mediate homophilic binding, but neurite outgrowth on TAG-1 requires an L1-like molecule and β-1 integrins, Neuron, 12 (1994) 675-690.
23. Filbin, M., Walsh, F.S., Trapp, B.D., Pizzey, J.A. and Tennekoon, G.I., Role of myelin PO protein as a homophilic adhesion molecule, Nature, 334 (1990) 871-872.
24. Fischer, G., Kunemund, V. and Schachner, M., Neurite outgrowth patterns in cerebellar microexplant cultures are affected by antibodies to the cell surface glycoprotein L1, J. Neurosci., 6 (1986) 605-612.
25. Fushiki, S. and Schachner, M., Immunocytological localization of cell adhesion molecules L1 and CAM and the shared carbohydrate epitope L2 during development of the mouse neocortex, Dev. Brain Res., 24 (1986) 153-167.
26. Gennarini, G., Durbec, P., Boned, A., Rougon, G. and Goridis, C., transfected F3/F11 neuronal cell surface protein mediates intercellular adhesion and promotes neurite outgrowth, Neuron, 6 (1991) 595-606.
27. Hankin, M.H. and Lagenaur, C.F., Cell adhesion molecules in the early developing mouse retina: Retinal neurons show preferential outgrowth in vitro on L1 but not N-CAM, J. Neurobiol., 25 (1994) 472-487.
28. Ho, D.Y., Mocarski, E.S. and Sapolsky, R.M., Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene, Proc. Natl. Acad. Sci. USA, 90 (1993) 3655-3659.
29. Johnson, P.A., Wang, M.J. and Friedmann, T., Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants o herpes simplex virus type 1 but not by mutation of the virion host shutoff function, J. Virol., 68 (1994) 6347-6362.
30. Kadmon, G., Kowitz, A., Altevogt, P. and Schachner, M., The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions, J. Cell Biol., 110 (1990) 193-208.
31. Kaplitt, M.G., Pfaus, J.G., Kleopolos, S.T., Hanlon, B.A. Rabkin, S.D. and Pfaff, D.W., Expression of a functional foreign gene in adult mammalian brain following in vivo transfer via herpes simplex virus type 1 defective viral vector, Mol. Cell Neurosci., 2 (1991) 320-330.
32. Kaplitt, M.G., Kwong, A.D., Kleopoulus, S.P., Mobbs, C.V., Rabkin, S.D. and Pfaff, D.W., Preproenkephalin promoter yields region-specific and long-term expression in adult brain following direct in vivo gene transfer via a defective herpes simplex viral vector, Proc. Natl. acad. Sci. USA, 91 (1994) 8979-8983.
33. Kesslak, J.P., Neito-Sampedro, M., Globus, J. and Cotman, C.W., Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation, Exp. Neurol., 92 (1986) 377-390.
34. Kobayashi, M., Miura, M., Asou, H. and Uyemura, K., Molecular cloning of cell adhesion molecule L1 from human nervous tissue: a comparison of the primary sequences of L1 molecules of different origin, Biochim. Biophys. Acta, 1090 (1991) 238-240.
35. Kobayashi, S., Miura, M., Asou, H., Inoue, H.K., Ohye, C and Uyemura, K., Grafts of genetically modified fibroblasts expressing neural cell adhesion molecule L1 into transected spinal cord of adult rats, Neurosci. Lett., 188 (1995) 191-194.
36. Kowitz, A., Kadmon, G., Eckert, M., Schirrmacher, V., Schachner, M. and Altevogt, P., Expression and function of the neural cell adhesion molecule L1 in mouse leukocytes, Eur. J. Immunol., 22 (1992) 1199-1205.
37. Kromer, L.F. and Cornbrooks, C.J., Transplants of Schwann cell cultures promote axonal regeneration in the adult mammalian brain, Proc. Natl. Acad. Sci. USA, 82 (1985) 6330-6334.
38. Kujat, R., Miragall, F., Krause, D. Dermietzel, R. and Wrobel, K.H., Immunolocalization of the neural cell adhesion molecule L1 in non-proliferating epithelial cells of the male urogenital tract, Histochemistry, 103 (1995) 311-321.
39. Kuypers, H.G.J.M. and Ugolini, G., Viruses as transneuronal tracers, Trends Neurosci., 13 (1990) 71-75.
40. Laemmli, U.K. Cleavage of structural protein during the assembly of the head of bacteriophage T4, Nature, 227 (1970) 680-685.
41. Lagenaur, C. and Lemmon, V., An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension, Proc. Natl. Acad. Sci. USA, 84 (1987).
42. Lawrence, M.S., Ho, D.Y., Dash, R. and Sapolsky, R.M., Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss, Proc. Natl. Acad. Sci. USA, 92 (1995) 7247-7251.
43. Lemmon, V., Karr, K.L. and Lagenaur, C., L1-mediated axon outgrowth occurs via a homophilic binding mechanism, Neuron, 2 (1989) 1597-1603.
44. Linder, J., Rathjen, F.G. and Schachner, M., L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum, Nature, 305 (1983) 427-430.
45. Martini, R., Expression and functional roles of neural cell surface molecules and extracellular components during development and regeneration of peripheral nerves, J. Neurocytol., 23 (1994) 1-28.
46. McCathy, K.D. and de Vellis, J., Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue, J. Cell Biol., 85 (1990) 890-902.
47. McKeon, R.J., Schreiber, T.C., Rudge, J.S. and Silver, J., Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes, J. Neurosci., 11 (1991) 3393-3411.
48. McKnight, S.L. and Gavis, E.R., Expression of the herpes thymidine kinase gene in Xenopus laevis oocytes: an assay for the study of deletion mutants constructed in vitro, Nucleic Acids Res., 8 (1980) 5931-5948.
49. Mellerick, D.M. and Fraser, N.W., Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state, Virology, 158 (1987) 265-275.
50. Messer, A., The maintenance and identification of mouse cerebellar granule cells in monolayer culture, Brain Res., 130 (1977) 12-23.
51. Miragall, F., Kadmon, G., Husmann, M. and Schachner, M., Expression of cell adhesion molecules in the olfactory system of the adult mouse: presence of the embryonic form of N-CAM, Dev. Biol., 129 (1988) 516-531.
52. Mirsky, R., Jessen, K.R., Schachner, M. and Goridism, C., Distribution of the adhesion molecules N-CAM and L1 on peripheral neurons and glial in adult rats, J. Neurocytol., 15 (1986) 799-815.
53. Miura, M., Kobayashi, M., Asou, H. and Uyemura, K., Molecular cloning of cDNA encoding the rat neural cell adhesion molecule L1: the L1 isoforms in the cytoplasmic region are produced by differential splicing, FEBS Lett., 289 (1991) 91-95.
54. Miura, M., Asou, H., Kobayashi, M. and Uyemura, K., Functional expression of a full-length cDNA coding for rat neural cell adhesion molecule L1 mediates homophilic intercellular adhesion and migration of cerebellar neurons, J. Biol. Chem., 267 (1992) 10752-10758.
55. Moos, M., Tacke, R., Scherer, H., Teplow, D., Fruh, K. and Schachner, M., Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin, Nature, 334 (1985) 701-703.
56. New, K.C. and Rabkin, S.D., Co-expression of two gene products in the CNS using double-cassette defective herpes simplex virus vectors, Mol. Brain Res., 37 (1996) 317-323.
57. Noble, M., Fok-Seang, J. and Cohen, J., Glia are a unique substrate for the in vitro growth of central nervous system neurons, J. Neurosci., 4 (1984) 1892-1903.
58. Pakzaban, P., Geller, A.I. and Isacson, O., Effect of exogenous nerve growth factor on neurotoxicity of and neuronal gene delivery by a herpes simplex amplicon vector in the rat brain, Hum. Gene Ther., 5 (1994) 987-995.
59. Persohn, E. and Schachner, M., Immunoelectron microscopic localization of the neural cell adhesion molecules L1 and N-CAM during postnatal development of the mouse cerebellum, J. Cell Biol., 105 (1987)569-576.
60. Reier, P.J., Bregman, B.S. and Wujek, J.R., Intraspinal transplantation of embryonic spinal cord tissue in neonatal and adult rats, J. Comp. Neurol., 247 (1986) 275-296.
61. Reier, P.J., and Houle, J.D., The glial scar: Its bearing on axonal elongation and transplantation approaches to CNS repair. In Waxman, S.G. (Ed.), Advances in Neurology, Raven Press, New York, 1988.
62. Schnell, L., Schneider, R., Kilbeck, R., Barde, Y.-A. and Schewab, M.E., Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion, Nature, 170-173 (1994).
63. Schwab, M.E. and Caroni, P., Oligodendrocytes and CNS myelin are non-permissive for neutrite growth and fibroblast spreading in vitro, J. Neurosci., 8 (1988) 2381-2393.
64. Schwab, M.E., Kapfhammer, J.P. and Bandtlow, C.E., Inhibitors of neurite growth, Annu. Rev. Neurosci., 16 (1993) 565-595.
65. Seilheimer, B. and Schachner, M., Regulation of neural cell adhesion molecule expression on cultured mouse Schwann cells by nerve growth factor, EMBO J., 6 (1987) 1611-1616.
66. Seilheimer, B. and Schachner, M., Studies of adhesion molecules mediating interactions between cells of peripheral nervous system indicate a major role for L1 in mediating sensory neuron growth on Schwann cells in culture, J. Cell Biol., 107 (1988) 341-351.
67. Smith, G.M., Miller, R.H. and Silver, J., Changing role of forebrain astrocytes during development, regenerative failures and induced regeneration upon transplantation, J. Comp. Neurol., 251 (1986) 23-43.
68. Smith, G.M., Rutishauser, U., Silver, J. and Miller, R.H., Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth, Dev. Biol., 138 (1990) 377-390.
69. Southern, E.M., Detection of specific sequences among DNA fragments separated by gel electrophoresis, J. Mol. Biol., 98 (1975) 503-517.
70. Spaete, R.R. and Frenkel, N., The herpes simplex virus amplicon: A new eukaryotic defective-virus cloning-amplifying vector, Cell, 30 (1982) 295-304.
71. Stallcup, W.B., Arner, L. and Levine, J., Antiserum against the PC12 cell defines cel surface antigens specific for neurons and Schwann cells, J. Neurosci., 3 (1983) 53-69.
72. Styren, S.D., Miller, P.D., Lagenaur, C.F. and DeKosky, S.T., Alternate strategies in lesion-induced reactive synaptogenesis: Differential expression of L1 in two populations of sprouting axons, J. Comp. Neurol., 131 (1995) 165-173.
73. Takeichi, M., The cadherins: cell-cell adhesion molecules controlling animal morphogenesis, Dev. (Camb.), 102 (1988) 639-655.
74. Tanaka, H., Matsui, T., Agata, A., Tomura, M., Kubota, I., McFarland, K.C., Kohr, B., Lee, A., Phillips, H.S. and Shelton, D.L., Molecular cloning and expression of a novel adhesion molecule SC1., Neuron, 7 (1991) 535-545.
75. Thor, G., Probstmeier, R. and Schachner, M., Characterization of the cell adhesion molecules L1, N-CAM and J1 in the mouse intestine, EMBO J., 6 (1987) 2581-2586.
76. Tuszynski, M.H. and Gage, F.H., Maintaining the neuronal phenotype after injury in the adults CNS. Neurotrophic factors, axonal growth substrates, and gene therapy, Mol. Neurobiol., 10 (1995) 151-164.
77. Verhaagen, J., Hermens, W.T.J.M.C., Oestreicher, A.B., Gispen, W.H., Rabkin, S.D., Pfaff, D.W. and Kaplitt, M.G., Expression of the growth-associated protein B-50/GAP43 via a defective herpes-simplex virus vector results in profound morphological changes in non-neuronal cells, Mol. Brain Res., 26 (1994) 26-36.
78. Williams, E.J., Doherty, P., Turner, G., Reid, R.A., Hemperly, J.J. and Walsh, F.S., Calcium influx into neurons can solely account for cell-contact dependent neurite outgrowth stimulated by transfected L1, J. Cell Biol., 119 (1992) 885-892.
79. Wong, E.V., Cheng, G.H., Payne, H.R. and Lemmon, V., The cytoplasmic domain of the cell adhesion molecule L1 is not required for homophilic adhesion, Neurosci. Lett., 200 (1995) 155-158.
80. Wood, M.J.A., Brynes, A.P., Kaplitt, M.G., Pfaff, D.W. Rabkin, S.D. and Charlton, H.M., Specific patterns of defective HSV-1 gene transfer in the adult central nervous system: Implications for gene targeting, Exp. Neurol., 130 (1994) 127-140.
81. Wunderlich, G., Stichel, C.C., Schroeder, W.O. and Muller, H.W., Transplants of immature astrocytes promote axonal regeneration in the adult rat brain, Glia, 10 (1994) 49-58.
82. Zhang, Y., Campbell, G., Anderson, P.N., Martini, R., Schachner, M. and Lieberman, A.R., Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts. 1. Neural cell adhesion molecules, J. Comp. Neurol., 361 (1995) 193-209.
83. Zuber, M.X., Goodman, D.W., Karns, L.R. and Fishman, M.C., The neuronal growth-associated protein GAP-43 induces filopodia in non-neuronal cells, Science, (1989) 1193-1195.