New research avenues in toxicology: 7-gas N-Gas Model, toxicant suppressants, and genetic toxicology

Toxicology

Volumn 115, Issue 1-3, 1996, Pages 89-106

  Levin, Barbara C ^a  

^a NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

Combustion gases; Genetic toxicology; N Gas Model; Polyurethane foam; Toxicant suppressants

Indexed keywords

CARBON DIOXIDE; CARBON MONOXIDE; FLAME RETARDANT; HYDROBROMIC ACID; HYDROCHLORIC ACID; HYDROGEN CYANIDE; NITROGEN DIOXIDE;

COMBUSTION; CONFERENCE PAPER; DNA DAMAGE; DRUG INTERACTION; DRUG TOXICITY; FIRE; GENETIC TOXICOLOGY; PRIORITY JOURNAL; STANDARD; TECHNIQUE; TECHNOLOGY;

ANIMALS; DNA DAMAGE; FIRES; HUMANS; MUTAGENICITY TESTS; POLYURETHANES; RESEARCH DESIGN; SMOKE INHALATION INJURY; TOXICOLOGY;

EID: 0030608473     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(96)03497-X     Document Type: Conference Paper

References (41)

1. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. and Struhl, K. (1993) DNA sequencing, Chapter 7. Current Protocols in Molecular Biology, Vol. 1, John Wiley and Sons Inc., New York, pp. 7.0.1.-7.7.22.
2. Babrauskas, V., Levin, B.C., Gann, R.G., Paabo, M., Harris, R.H. Jr., Peacock, R.D. and Yusa, S. (1991a) Toxic potency measurement for fire hazard analysis. US National Institute of Standards and Technology, Gaithersburg, MD. NIST Special Publication 827.
3. Babrauskas, V., Harris, R.H., Jr., Braun, E., Levin, B.C., Paabo, M. and Gann, R.G. (1991b) The role of bench-scale test data in assessing full-scale fire toxicity. US National Institute of Standards and Technology, Gaithersburg, MD. NIST Technical Note 1284.
4. Braun, E., Levin, B.C., Paabo, M., Gurman, J.L., Holt, T. and Steel, J.S. (1987) Fire toxicity scaling. US National Bureau of Standards, Gaithersburg, MD. Publication NBSIR 87-3510.
5. Braun, E., Levin, B.C., Paabo, M., Gurman, J.L., Clark, H.M. and Yoklavich, M.F. (1988) Large-scale compartment fire toxicity study: comparison with small-scale toxicity test results. US National Bureau of Standards, Gaithersburg, MD. Publication NBSIR 88-3764.
6. Di Giorgio, C., De Méo, M.P., Laget, M., Guiraud, H., Botta, A. and Duménil, G. (1994) The micronucleus assay in human lymphocytes: screening for inter-individual variability and application to biomonitoring. Carcinogenesis 15, 313-317.
7. Dizdaroglu, M., Rao, G., Halliwell, B. and Gajewski, E. (1991) Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions. Arch. Biochem. Biophys. 285, 317-324.
8. Frenech, M. and Rinaldi, J. (1994) The relationship between micronuclei in human lymphocytes and plasma levels of vitamin C, vitamin E, vitamin B12, and folic acid. Carcinogenesis 15, 1405-1411.
9. Freshney, R.I. (1987) Culture of Animal Cells: A Manual of Basic Techniques, 2nd Edn., Alan R. Liss Inc., New York, p. 246.
10. Goldstein, E., Goldstein, F., Goldberg, S.B. and Kaplan, E. (1980) Absorption and transport of nitrogen oxides. In: S.D. Lee (Ed), Nitrogen Oxides and their Effects on Health, Ann Arbor Science, Ann Arbor, MI, pp. 143-160.
11. Gregory, K.L., Malinoski, V.F. and Sharp, C.R. (1969) Cleveland Clinic fire survivorship study, 1929-1965. Arch. Environ. Health 18, 508-515.
12. Grossman, L.I. (1995) Mitochondrial mutations and human disease. Environ. Mol. Mutagen. 25 (Suppl. 26), 30-37.
13. Guidotti, T.L. (1978) The higher oxides of nitrogen: inhalation toxicology. Environ. Res. 15, 443-472.
14. Hartzell, G.E., Grand, A.F. and Switzer, W.G. (1990) Toxicity of smoke containing HCI. In: G.L. Nelson (Ed), Fire and Polymers: Hazards Identification and Prevention, ACS Symposium Series 425, American Chemical Society, Washington, DC, pp. 12-20.
15. Hopgood, R., Sullivan, K.M. and Gill, P. (1992) Strategies for automated sequencing of human mitochondrial DNA directly from PCR products. BioTechniques 13, 82-92.
16. Jellinek, H.H.G. and Takada, K. (1977) Toxic gas evolution from polymers: evolution of hydrogen cyanide from polyurethanes. J. Polymer Sci. 15, 2269-2288.
17. Jellinek, H.H.G., Chaudhuri, A. and Takada, K. (1978) Inhibition of hydrocyanic acid evolution from polyurethanes during oxidative degradation. Polymer J. 10, 253-268.
18. Kohler, S.W., Provost, G.S., Kretz, P.L., Fieck, A. and Short, J.M. (1990) An in vivo assay using transgenic mice to analyze spontaneous and induced mutations at the nucleic acid level. Strategies Mol. Biol. 3, 19-21.
19. Levin, B.C. (1992) The development of a new small-scale smoke toxicity test method and its comparison with real-scale fire tests. Toxicol. Lett. 64/65, 257-264.
20. Levin, B.C., Fowell, A.J., Birky, M.M., Paabo, M., Stolte, A. and Malek, D. (1982) Further development of a test method for the assessment of the acute inhalation toxicity of combustion products. US National Bureau of Standards, Gaithersburg, MD. Publication NBSIR 82-2532.
21. Levin, B.C., Paabo, M., Bailey, C., Harris, S.E. and Gurman, J.L. (1985a) Toxicological effects of the interactions of fire gases and their use in a toxic hazard assessment computer model. Toxicologist 5, 127.
22. Levin, B.C., Paabo, M., Fultz, M.L. and Bailey, C.S. (1985b) Generation of hydrogen cyanide from flexible Polyurethane foam decomposed under different combustion conditions. Fire Mater. 9, 125-133.
23. Levin, B.C., Paabo, M., Gurman, J.L. and Harris, S.E. (1987a) Effects of exposure to single or multiple combinations of the predominant toxic gases and low oxygen atmospheres produced in fires. Fundam. Appl. Toxicol. 9, 236-250.
24. Levin, B.C., Paabo, M., Gurman, J.L., Harris, S.E. and Braun, E. (1987b) Toxicological interactions between carbon monoxide and carbon dioxide. Toxicology 47, 135-164.
25. Levin, B.C., Gurman, J.L., Paabo, M., Baier, L. and Holt, T. (1988a) Toxicological effects of different time exposures to the fire gases: ca bon monoxide or hydrogen cyanide or to carbon monoxide combined with hydrogen cyanide or carbon dioxide. In: Proceedings of the Ninth Joint Panel Meeting of the US-Japan (UJNR) Panel on Fire Research and Safety, US National Bureau of Standards, Gaithersburg, MD. Publication NBSIR 88-3753.
26. 2, and reduced oxygen. In: Polyurethane 1988, Proceedings of 31st Society of Plastics Meeting, Technomic Publishing Co. Inc., Lancaster, PA, pp. 249-252.
27. Levin, B.C., Gurman, J.L., Paabo, M., Harris, R.H., Clark, H.M. and Yoklavich, M.F. (1988c) Reduction of both atmospheric hydrogen cyanide and acute inhalation toxicity of combustion products from flexible polyurethane by copper additives. First Annual Report to the International Copper Research Association, Inc., from the US National Institute of Standards and Technology, Gaithersburg, MD.
28. Levin, B.C., Paabo, M., Highbarger, L. and Eller, N. (1989a) Synergistic effects of nitrogen dioxide and carbon dioxide following acute inhalation exposures in rats. US National Institute of Standards and Technology, Gaithersburg, MD. Publication NISTIR 89-4105.
29. Levin, B.C., Paabo, M., Harris, R.H., Eller, N. and Highbarger, L. (1989b) Copper additives decrease the acute inhalation toxicity of the combustion products of flexible polyurethane by inhibiting hydrogen cyanide generation. Second Annual Report to the International Copper Association, Ltd., from the US National Institute of Standards and Technology, Gaithersburg, MD.
30. Levin, B.C., Paabo, M., Harris, R.H., Clark, H.M., Yoklavich, M.F., Eller, N. and Highbarger, L. (1989c) The effect of copper additives on atmospheric hydrogen cyanide and acute inhalation toxicity from the combustion products of flexible polyurethane. In: The Proceedings of the Fire Retardant Chemicals Association Fall Conference, Scottsdale, AZ, pp. 107-112.
31. Levin, B.C., Braun, E., Shields, J.R. and Lowe, D. (1990) Reduction of hydrogen cyanide concentrations and acute inhalation toxicity from flexible polyurethane foam combustion products by the addition of copper compounds, part III: the effect of copper additives on the flammability characteristics of flexible polyurethane foam. US National Institute of Standards and Technology, Gaithersburg, MD. Publication NISTIR 4441.
32. Levin, B.C., Paabo, M. and Schiller, S.B. (1991) A standard reference material for calibration of the cup furnace toxicity method for assessing the acute inhalation toxicity of combustion products. J. Res. Natl. Inst. Standards Technol. 96, 741-755.
33. Levin, B.C., Braun, E., Paabo, M., Harris, R.H. and Navarro, M. (1992) Reduction of hydrogen cyanide concentrations and acute inhalation toxicity from flexible polyurethane foam combustion products by the addition of copper compounds, part IV: effects of combustion conditions and scaling on the generation of hydrogen cyanide and toxicity from flexible polyurethane foam with and without copper compounds. US National Institute of Standards and Technology, Gaithersburg, MD. Publication NISTIR 4989.
34. Levin, B.C., Braun, E., Navarro, M. and Paabo, M. (1995) Further development of the N-Gas Model: an approach for predicting the toxic potency of complex combustion mixtures. In: G.L. Nelson (Ed), Fire and Polymers II, Chapter 20, American Chemical Society Symposium Series 599, Washington, DC, pp. 293-311.
35. Lieu, P.J., Magill, J.H. and Alarie, Y.C. (1981) Flammability-toxicity ratings of some polyphosphazene and polyurethane foams. J. Comb. Tox. 8, 242-259.
36. Mayorga, M.A., Januskiewicz, A.J. and Lehnert, B.E. (1995) Environmental nitrogen dioxide exposure hazards of concern to the U.S. Army. In: G.L. Nelson (Ed), Fire and Polymers II, Chapter 22, American Chemical Society Symposium Series 599, Washington, DC, pp. 323-343.
37. Ritchie, G.D. and Rossi, J., III (1995) Application of the Naval Medical Research Institute Toxicology Detachment neurobehavioral screening battery to combustion toxicology. In: G.L. Nelson (Ed), Fire and Polymers II, Chapter 23, American Chemical Society Symposium Series 599, Washington, DC, pp. 344-365.
38. Rodkey, F.L. (1976) A mechanism for the conversion of oxyhemoglobin to methemoglobin by nitrite. Clin. Chem. 22, 1986-1990.
39. Singh, N.P., McCoy, M.T., Tice, R.R. and Schneider, E.L. (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184-191.
40. x in fire gas toxicity. In: Proceedings of the Canada-Japan-USA Trilateral Cooperative Study on Fire Gas Toxicity, Third Expert Meeting, Ottawa, Canada.
41. Weil, E. and Choudhary, V. (1995) Flame-retarding plastics and elastomers with melamine. J. Fire Sci. 13, 104-126.