Thermodynamics of ligand binding to the cloned δ-opioid receptor

European Journal of Pharmacology

Volumn 318, Issue 2-3, 1996, Pages 505-509

  Maguire, Patricia A ^a   Loew, Gilda H ^a  

^a MOLECULAR RESEARCH INSTITUTE   (United States)

Author keywords

Opioid receptor; Ligand binding thermodynamics; Model; Pharmacophore

Indexed keywords

DELTA OPIATE RECEPTOR; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; NALTRINDOLE; OPIATE AGONIST; OPIATE ANTAGONIST; PSEUDOPEPTIDE;

ARTICLE; BINDING SITE; ENTHALPY; ENTROPY; LIGAND BINDING; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

ANIMALS; BENZAMIDES; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; MICE; OLIGOPEPTIDES; PIPERAZINES; RECEPTORS, OPIOID, DELTA; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 0030607724     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00894-1     Document Type: Article

References (18)

1. Agarwal, A., M.F. Beatty, P.A. Maguire and G.H. Loew, 1995, Molecular determinants of recognition at the δ-opioid receptor, Analgesia 1, 247.
2. Alcorta, I. and G.H. Loew, 1996, A 3D model of the δ-opioid receptor and ligand-receptor complexes, Protein Eng. 9, 573.
3. Borea, P.A., G.M. Berteli and G, Gilli, 1988, Temperature dependence of the binding of μ, δ and κ agonists to the opiate receptor in guinea pig brain, Eur. J. Pharmacol. 146, 247.
4. Evans, C.J., D.E. Keith, H. Morrison, K. Magendzo and R.H. Edwards, 1992, Cloning of a delta opioid receptor by functional expression, Science 258, 1952.
5. Gilman, A.G., 1987, G proteins: transducers of receptor-generated signals, Annu. Rev. Biochem. 56, 615.
6. Hitzemann, R., 1988, Thermodynamic aspects of drug-receptor interactions, Trends Pharmacol. Sci. 9, 408.
7. Hitzemann, R., M. Murphy and J. Curell, 1985, Opiate receptor thermodynamics: agonist and antagonist binding, Eur. J. Pharmacol. 108, 171.
8. Huang, P., S. Kim and G.H. Loew, 1996, Development of a common 3D pharmacophore for δ-opioid recognition from peptides and nonpeptides using a novel computer program, J. Comput.-Aided Mol. Des. (in press).
9. Munson, P.J. and D. Rodbard, 1980, LIGAND: a versatile computerized approach for characterization of ligand-binding systems, Anal. Biochem. 107, 220.
10. Raffa, R.B. and F. Porreca, 1989, Thermodynamic analysis of the drugreceptor interaction, Life Sci. 44, 245.
11. Raffa, R.B., K.D. Wild, H.I. Mosberg and F. Porreca, 1992, Thermodynamic analysis of the temperature dependence of the dissociation constant of naloxone at opioid delta receptors in the mouse isolated vas deferens, J. Pharmacol. Exp. Ther. 263, 1030.
12. 2,5]enkephalin at δ-opioid receptors in the mouse isolated vas deferens, Eur. J. Pharmacol. Mol. Pharmacol. Sect. 244, 231.
13. 2+ and other divalent cations on the binding of tritiated opioid ligands, J. Neurochem. 59, 467.
14. Testa, B., P. Jenner, G.J. Kilpatrick, N. El Tayar, H. Van de Waterbeemd and C.D. Marsden, 1987, Do thermodynamic studies provide information on both the binding to and the activation of dopaminergic and other receptors?, Biochem. Pharmacol. 36, 4041.
15. Toll, L., C. Keys, D. Spangler and G.H. Loew, 1984, Computer-assisted determination of benzodiazepine receptor heterogeneity, Eur. J. Pharmacol. 99, 203.
16. Weiland, G.A., K.P. Minneman and P.B. Molinoff, 1979, Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor, Nature 281, 114.
17. Weiland, G.A., K.P. Minneman and P.B. Molinoff, 1980, Thermodynamics of agonist and antagonist interactions with mammalian β-adrenergic receptors. Mol. Pharmacol. 18, 341.
18. Wild, K.D., F. Porreca, H.I. Yamamura and R.B. Raffa, 1994, Diferentiation of receptor subtypes by thermodynamic analysis: application to opioid δ receptors, Proc. Natl, Acad. Sci. USA 91, 12018.