Antiarrhythmic effects of an aconitine-like compound, TJN-505, on canine arrhythmia models

European Journal of Pharmacology

Volumn 318, Issue 2-3, 1996, Pages 333-340

  Arita, Jiro ^a   Xue, Yi Xue ^a   Aye, Nu Nu ^a   Fukuyama, Kiyoshi ^b   Wakui, Yoko ^b   Niitsu, Kazuaki ^b   Maruno, Masao ^b   Siying, Chen ^c   Hashimoto, Keitaro ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b TSUMURA AND CO   (Japan)

^c KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

Aconitine; Antiarrhythmic drug; Arrhythmia model, canine; TJN 505

Indexed keywords

20 ETHYL 1ALPHA,16BETA DIMETHOXY 14ALPHA (4 METHOXYBENZOYLOXY)ACONITANE 8,13 DIOL; ACONITINE; ADRENALIN; ANTIARRHYTHMIC AGENT; DIGITALIS; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DOG; DRUG BLOOD LEVEL; ELECTROSTIMULATION; FEMALE; HEART INFARCTION; HEART VENTRICLE ARRHYTHMIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PR INTERVAL; PRIORITY JOURNAL; QRS COMPLEX; QT INTERVAL;

ACONITINE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; CALCIUM CHANNELS; DIGITALIS; DOGS; ELECTROCARDIOGRAPHY; EPINEPHRINE; FEMALE; MALE; PLANTS, MEDICINAL; PLANTS, TOXIC; POTASSIUM CHANNELS; SODIUM CHANNELS;

EID: 0030607696     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00793-5     Document Type: Article

References (28)

1. Chiao, H., S.W. Pelletier, H.K. Desai, W.R. Rebagay and R.W. Caldwell, 1995, Effect of diterpenoid alkaloids on cardiac sympathetic efferent and vagal afferent nerve activity, Eur. J. Pharmacol. 283, 103.
2. Dukes, I.D. and E.M. Vaughan Williams, 1984, The multiple modes of action of propafenone, Eur. Heart J. 5, 115.
3. El-Sherif, N., R. Mehra, W.B. Gough and R.H. Zeiler, 1982, Ventricular activation patterns of spontaneous and induced ventricular rhythms in canine one-day-old myocardial infarction, Circ, Res. 51, 152.
4. Friedman, P.L., J.R. Stewart, J.J. Fenoglio Jr. and A.L. Wit, 1973, Survival of subendocardial Purkinje fibers after extensive myocardial infarction in dogs, Circ. Res. 33, 597.
5. Harris, A.S., 1950, Delayed development of ventricular ectopic rhythms following experimental coronary occlusion, Circulation 1, 1318.
6. Haruno, A. and K. Hashimoto, 1993, Antiarrhythmic effects of bisaramil in canine models of ventricular arrhythmia, Eur. J. Pharmacol. 233, 1.
7. Hashimoto, K., A. Haruno, T. Matsuzaki, A. Sugiyama and K. Akiyama, 1991a, Effects of antiarrhythmic drugs on canine ventricular arrhythmia models: which electrophysiological characteristics of drugs are related to their effectiveness?, Cardiovasc. Drugs Ther. 5, 805.
8. Hashimoto, K., A. Haruno, T. Matsuzaki, A. Hirasawa, T. Awaji and Y. Uemura, 1991b, Effects of a new class III antiarrhythmic drug (E-4031) on canine ventricular arrhythmia models, Asia Pac. J. Pharmacol. 6, 127.
9. Honerjäger, P. and A. Meissner, 1983, The positive inotropic effect of aconitine, Naunyn-Schmiedeberg's Arch. Pharmacol. 322, 49.
10. Katoh, H., S. Ogawa, I. Furuno, Y. Sato, S. Yoh, K. Saeki and Y. Nakamura, 1990, Electrophysiologic effects of E-4031, a class III antiarrhythmic agent, on re-entrant ventricular arrhythmias in a canine 7-day-old myocardial infarction model, J. Pharmacol. Exp. Ther. 253, 1077.
11. Kondoh, K., H. Hashimoto, H. Nishiyama, K. Umemura, T. Ozaki, T. Uematsu and M. Nakashima, 1994, Effects of MS-551, a new class III antiarrhythmic drugs, on programmed stimulation-induced ventricular arrhythmias, electrophysiology, and hemodynamics in a canine myocardial infarction model, J. Cardiovasc, Pharmacol. 23, 674.
12. Kou, W.H., S.D. Nelson, J.J. Lynch, D.G. Montgomery, L. DiCarlo and B.R. Lucchesi, 1987, Effect of flecainide acetate on preventation of electrical induction of ventricular tachycardia and occurrence of ischemic ventricular fibrillation during the early postmyocardial infarction period: evaluation in a conscious canine model of sudden death, J. Am. Coll. Cardiol. 9, 359.
13. Ledda, F., L. Mantelli, S. Manzini, S. Amerini and A. Mugelli, 1981, Electrophysiological and antiarrhythmic properties of propafenone in isolated cardiac preparations, J. Cardiovasc. Pharmacol. 3, 1162.
14. 2+-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo, J. Cardiovasc. Pharmacol. 22, 120.
15. Lucchesi, B.R. and H.F. Hardman, 1961, The influence of dichloroisoproterenol (DCI) and related compounds upon ouabain and acetylstrophanthidin induced cardiac arrhythmias, J. Pharmacol. Exp. Ther. 132, 372.
16. Lynch, J.J., L.A. DiCarlo, D.G. Montogomery and B.R. Lucchesi, 1987, Effects of flecainide acetate on ventricular tachyarrhythmia and fibrillation in dogs with recent myocardial infarction, Pharmacology, 35, 181.
17. Mitsuhashi, H. and K. Hashimoto, 1988, Antiarrhythmic profile of a new class 1 drug, AHR10718, on canine atrial and ventricular arrhythmia models, Jpn. J. Pharmacol. 46, 349.
18. 2+ channel blocker in models of ventricular arrhythmia in dogs, Eur. J. Pharmacol. 231, 363.
19. Miyazaki, T., S. Ogawa, T. Sakai, M. Hosokawa, K. Sakurai and Y. Nakamura, 1988, Effects of class I drugs on reentrant ventricular tachycardia in a canine model of myocardial infarction: on their antiarrhythmic and proarrhythmic mechanisms, Jpn. Circ. J. 52, 254.
20. Niitsu, K., Y. Ikeya and H. Mitsuhashi, 1990, Studies on alkaloids from Aconitum contortum (I), Heterocycles 31, 1517.
21. Ogawa, S., H. Mitamura and H. Katoh, 1993, Effect of E-4031, a new class III antiarrhythmic drug, on reentrant ventricular arrhythmias -comparison with conventional class I drugs, Cardiovasc. Drugs Ther. 7, 621.
22. Peper, K. and W. Trautwein, 1967, The effect of aconitine on the membrane current in cardiac muscle, Pflüg. Arch. 296, 328.
23. 2+, Jpn. J. Physiol. 37, 59.
24. Schmidt, H. and O, Schmitt, 1974, Effect of aconitine on the sodium permeability of the node of Ranvier, Pflüg. Arch. 349, 133.
25. Schulze, J.J. and J. Knops, 1982, Effects of flecainide on contractile force and electrophysiological parameters in cardiac muscle, Arzneim.-Forsch. 32, 1025.
26. Tai, Y.T., P.P.H. But, K. Young and C.P. Lau, 1992, Cardiotoxicity after accidental herb-induced aconite poisoning, Lancet 340, 1254.
27. Tanz, R.D., J.B. Robbins, K.L. Kemple and P.A. Allen, 1973, Pharmacology of aconitine-induced automaticity of cat papillary muscle. I. Effect of dose, tension, rate and endogenous catecholamines, J. Pharmacol. Exp. Ther. 185, 427.
28. Winslow, E., 1980, Evaluation of antagonism of aconitine-induced dysrhythmias in mice as a method of detecting and assessing antidysrhythmic activity, Br. J. Pharmacol. 71, 615.