In vivo blockade of thalamic GABA(B) receptors increases excitatory amino-acid levels

European Journal of Pharmacology

Volumn 318, Issue 2-3, 1996, Pages 295-300

  Nyitrai, Gabriella ^a   Emri, Zsuzsa ^b   Crunelli, Vincenzo ^b   Kékesi, Katalin A ^a   Dobolyi, Árpád ^a   Juhász, Gabor ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Aspartate; GABA(B) receptor; Glutamate; Microdialysis; Thalamus

Indexed keywords

2 HYDROXYSACLOFEN; 3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ASPARTIC ACID; EXCITATORY AMINO ACID; GLUTAMIC ACID; TAURINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LATERAL GENICULATE BODY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; THALAMUS; THALAMUS VENTRAL NUCLEUS;

ANIMALS; ASPARTIC ACID; BACLOFEN; GLUTAMIC ACID; MALE; MICRODIALYSIS; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, WISTAR; RECEPTORS, GABA-B; TAURINE; THALAMUS;

EID: 0030607671     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00813-8     Document Type: Article

References (31)

1. Balcar, V.J. and Y. Li, 1992, Heterogenity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system, Life Sci. 51, 1467.
2. B) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (Ventrobasal thalamus): a possible mechanism for the generation of absence-like seizures induced by GHB, J. Pharmacol. Exp. Ther. 273, 1534.
3. B receptors may increase excitatory amino acid-mediated transmission, Pharmacol. Commun. 2, 28.
4. B receptors, Trends Pharmacol. Sci. 14, 259.
5. Bowery, N.G., D.L. Hill, A.L. Hudson, A. Doble, D.N. Middlemiss, J. Shaw and M. Turnbull, 1980, (-) Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor, Nature 283, 92.
6. B receptor site distribution in the rat central nervous system, Neuroscience 20, 365.
7. Caddick, S.J., I.M. Stanford and J.E. Chad, 1995, 2-Hydroxy-saclofen causes a phaclofen-reversible reduction in population spike amplitude in the rat hippocampal slice, Eur. J. Pharmacol. 274, 41.
8. B binding sites in rat central nervous system: a quantitative autoradiographic study, Neuroscience 34, 341.
9. B receptors in excitation and inhibition of thalamocortical cells, Trends Neurosci. 14, 16.
10. Currie, D.N. and J.S. Kelly, 1981, Glial versus neuronal uptake of glutamate, J. Exp. Biol. 95, 181.
11. B receptors on thalamic sensory afferents, Neuroscience 72, 689.
12. Ferkaney, J. and J.T. Coyle, 1986, Heterogenity of sodium dependent excitatory amino acid uptake mechanisms in rat brain, J. Neurosci. Res. 16, 491.
13. Juhász, G., J. Tarcali, K. Pungor and E. Pungor, 1989, Electrochemical calibration of in vivo brain dialysis samplers, J. Neurosci. Methods 29, 131.
14. B receptors decreases EEG synchronization, Neurosci. Lett. 172, 155.
15. B receptors, Neurosci. Lett. 92, 92.
16. B receptors, Pharmacol. Ther. 67, 187.
17. B receptor antagonists on responses of VPM neurons, J. Neurophysiol. 71, 1716.
18. A IPSCs in thalamocortical neurones, Soc. Neurosci. Abstr. 21, 47. 11.
19. Lehmann, A., 1990, De-arrangements in cerebral osmohomeostasis: a common denominator for stimulation of taurine and phosphoethanolamine release, in: Taurine: Functional Neurochemistry, Physiology and Cardiology (Wiley-Liss, New York, NY) p. 337.
20. B neurotransmission in the control of absence seizures in the rat, Neuroscience 48, 87.
21. Martin, D., G.A. Bustos, M.A. Bowe, S.D. Bray and J.V. Nadler, 1991, Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area, J. Neurochem. 56, 1647.
22. B receptors and the effects of baclofen in the mammalian central nervous system, Prog. Neurobiol. 46, 423.
23. B receptors play a major role in paired-pulse facilitation in area CA1 of the rat hippocampus, Brain Res. 531, 55.
24. Pellegrino, L.J. and A.J. Cushman, 1967, A Stereotaxic Atlas of the Rat Brain (Appleton-Century-Crofts, New York, NY).
25. B) receptor subtype, Brain Res. 604, 325.
26. Robinson, M.B., M. Hunter-Ensor and J. Sinor, 1991, Pharmacologically distinct sodium-dependent L[H3] glutamate transport process in rat brain, Brain Res. 544, 196.
27. Schousboe, A. and H. Pasantes-Morales, 1992, Role of taurine in neural cell volume regulation, Can. J. Physiol. Pharmacol. 70, S356.
28. B-mediated mechanisms in experimental generalised absence seizures, Eur. J. Pharmacol, 213, 343.
29. +-dependent IPSP in cat and rat thalamic and hippocampal neurones, Brain Res. 448, 351.
30. B antagonist, CGP 35348, does not affect GABA, glutamate or aspartate in microdialysates of the striatum of conscious rats, Naunyn-Schmiedeberg's Arch. Pharmacol. 345, 548.
31. Zhou, M., C.L. Peterson, Y.B. Lu and J.V. Nadler, 1995, Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands, J. Neurochem. 64, 1556.