Evidence for receptor subtype cross-talk in the mitogenic action of serotonin on human small-cell lung carcinoma cells

European Journal of Pharmacology

Volumn 318, Issue 2-3, 1996, Pages 497-504

  Vicentini, Lucia M ^a   Cattaneo, Maria G ^a   Fesce, Riccardo ^a,b  

^a Department of Medical Pharmacology ^*  (Italy)

^b CNR   (Italy)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); 5 HT receptor subtype; Receptor cross talk; Small cell lung carcinoma

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ADENYLATE CYCLASE; METERGOLINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1D RECEPTOR; SPIPERONE; SUMATRIPTAN;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MITOGENESIS; PRIORITY JOURNAL;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARCINOMA, SMALL CELL; HUMANS; LUNG NEOPLASMS; METERGOLINE; MITOGENS; RECEPTORS, SEROTONIN; SEROTONIN; TEMPERATURE; THYMIDINE; TUMOR CELLS, CULTURED;

EID: 0030607663     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00812-6     Document Type: Article

References (18)

1. 1A receptors, Br. J. Pharmacol. 100, 793.
2. Blier, P. and C. De Montigny, 1994, Current advances and trends in the treatment of depression, Trends Pharmacol. Sci. 15, 220.
3. 1A receptors: variations in intrinsic activity studied in transfected HeLa cells, Naunyn-Schmiedeberg's Arch. Pharmacol. 345, 257.
4. Cattaneo, M.G., A. Codignola, L.M. Vicentini, F. Clementi and E. Sher, 1993, Nicotine stimulates a serotoninergic autocrine loop in human small-cell lung carcinoma, Cancer Res. 53, 5566.
5. 1D receptor type is involved in stimulation of cell proliferation by serotonin in human small cell lung carcinoma, Eur. J. Pharmacol. 268, 425.
6. 1D receptors, Eur. J. Pharmacol. 291, 209.
7. Cuttitta, F., D.N. Carney, J. Mulshine, T.W. Moody, J. Fedorko, A. Fishler and J.D. Minna, 1985, Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer, Nature 316, 823.
8. Goldberg, H. and R. Finnerty, 1979, The comparative efficacy of buspirone and diazepam in the treatment of anxiety, Am. J. Psychiatry 136, 1184.
9. Kahan, C., K. Seuwen, S. Meloche and J. Pouysségur, 1992. Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts, J. Biol. Chem. 267, 13369.
10. Lakoski, J.M. and G.K. Aghajanian, 1985, Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus, Neuropharmacology 24, 265.
11. 1A receptors in the dorsal raphe nucleus, Eur. J. Pharmacol. 149, 9.
12. Moody, T.W. and F. Cuttitta, 1993, Growth factor and peptide receptors in small cell lung cancer, Life Sci. 52, 1161.
13. Nakanishi, J., J.L. Mulshine, P.G. Kasprzyk, R.B. Natale, R. Maneckjie, I. Avis, A.M. Treston, A.F. Gazdar, J.D. Minna and F. Cuttitta, 1988, Insulin-like growth factor I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro, J. Clin. Invest. 82, 354.
14. Saudou, F. and R. Hen, 1994, 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates, Neurochem. Int. 25, 503.
15. 1A receptor antagonist, Eur. J. Pharmacol. 244, 251.
16. Seger, R., D. Seger, A.A. Reszka, E.S. Munar, H. Eldar-Finkelman, G. Dobrowolska, A.M. James, J.S. Campbell, E.H. Fisher and E.G. Krebs, 1994, Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells, J. Biol. Chem. 269, 25699.
17. 1 receptors mediate inhibition of cAMP production in neurones, Eur. J. Pharmacol. 120, 227.
18. Zifa, E. and G. Fillion, 1992, 5-Hydroxytryptamine receptors, Pharmacol. Rev. 44, 401.