Role of operator subsites in arc repression

Journal of Molecular Biology

Volumn 264, Issue 2, 1996, Pages 233-242

  Smith, Tracy L ^a   Sauer, Robert T ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Bacteriophage P22; Cooperative DNA binding; Multimerization; Transcriptional regulation

Indexed keywords

ARTICLE; BACTERIOPHAGE P22; MOLECULAR STABILITY; NONHUMAN; OPERATOR; OPERON; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

FORMICIDAE;

EID: 0030606226     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0637     Document Type: Article

References (35)

1. Bell, A., Gaston, K., Williams, R., Chapman, K., Kolb, A., Buc, H., Minchin, S., Williams, J. & Busby, S. (1990). Mutations that alter the ability of the Escherichia coli cyclic AMP receptor protein to activate transcription. Nucl. Acids Res. 18, 7243-7250.
2. Brown, B. M. & Sauer, R. T. (1993). Assembly of the Arc repressor-operator complex: cooperative interactions between DNA-bound dimers. Biochemistry, 32, 1354-1363.
3. Brown, B. M., Milla, M. E., Smith, T. L. & Sauer, R. T. (1994). Scanning mutagenesis of the Arc repressor as a functional probe of operator recognition. Nature Struct. Biol. 1, 164-168.
4. Carlson, N. G. & Little, J. W. (1993). Highly cooperative DNA binding by the coliphage HK022 repressor. J. Mol. Biol. 230, 1108-1130.
5. Collado-Vides, J., Magasanik, B. & Gralla, J. D. (1991). Control site location and transcriptional regulation in Escherichia coli. Microbiol. Rev. 55, 371-394.
6. De Lorenzo, V., Herrero, M., Jakubzik, U. & Timmis, K. N. (1990). Mini-Tn5 transposon derivatives for insertion mutagenesis, promoter probing, and chromosomal insertion of cloned DNA in gram-negative eubacteria. J. Bacteriol. 172, 6568-6572.
7. Hager, D. A., Jin, D. J. & Burgess, R. R. (1990). Use of Mono Q high-resolution ionexchange chromatography to obtain highly pure and active Escherichia coli RNA polymerase. Biochemistry, 29, 7890-7894
8. He, Y.-Y., McNally, T., Manfield, I., Navratil, O., Old, I., Phillips, S. E. V., Saint-Girons, I. & Stockley, P. G. (1992). Probing met repressor-operator recognition in solution. Nature, 359, 431-433.
9. Hochschild, A., Irwin, N. & Ptashne, M. (1983). Repressor structure and the mechanism of positive control. Cell, 32, 319-325.
10. Kim, B. & Little, J. W. (1992). Dimerization of a specific DNA-binding protein on the DNA. Science, 255, 203-206.
11. Kuldell, N. & Hochschild, A. (1994). Amino acid substitutions in the -35 recognition motif of σ70 that result in defects in phage λ repressor-stimulated transcription. J. Bacteriol. 176, 2991-2998.
12. Li, M., Moyle, H. & Susskind, M. M. (1994). Target of the transcriptional activation function of phage λ cI protein. Science, 263, 75-77.
13. Liao, S.-M. (1988). PhD thesis, Carnegie-Mellon University, Pittsburgh, PA.
14. Mandecki, W. & Reznikoff, W. S. (1982). A lac promoter with a changed distance between -10 and -35 regions. Nucl. Acids Res. 10, 903-912.
15. McClure, W. R. (1985). Mechanism and control of transcription initiation in prokaryotes. Annu. Rev. Biochem. 54, 171-204.
16. Meyer, B. J., Maurer, R. & Ptashne, M. (1980). Gene regulation at the ri ght operator (OR) of bacteriophage 1. II. OR1, OR2, and OR3: their roles in mediating the effects of repressor and cro. J. Mol. Biol. 139, 163-194.
17. Milla, M. E., Brown, B. M. & Sauer, R. T. (1993). P22 Arc repressor: enhanced expression of unstable mutants by addition of polar C-terminal sequences. Protein Sci. 2, 2198-2205.
18. Miller, J. H. (1972). Experiments in Molecular Genetics, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
19. Niu, W., Zhou, Y., Dong, Q., Ebright, Y. & Ebright, R. H. (1994). Characterization of the activating region of Escherichia coli catabolite gene activator protein (CAP). I. Saturation and alanine-scanning mutagenesis. J. Mol. Biol. 243, 595-602.
20. Phillips, S. E. V., Manfield, I., Parsons, I., Davidson, B. E., Rafferty, J. B., Somers, W. S., Margarita, D., Cohen, G. N., Saint-Girons, I. & Stockley, P. G. (1989). Cooperative tandem binding of met repressor of Escherichia coli. Nature, 341, 711-715.
21. Ptashne, M. (1986). A Genetic Switch, Cell Press, Cambridge, MA.
22. Raumann, B. E., Brown, B. M. & Sauer, R. T. (1994a). Major groove recognition by β-sheets: the ribbon-helix-helix family of gene regulatory proteins. Curr. Opin. Struct. Biol. 4, 36-43.
23. Raumann, B. E., Rould, M. A., PabO, C. O. & Sauer, R. T. (1994b). DNA recognition by β-sheets in the Arc repressor-operator crystal structure. Nature, 367, 754-757.
24. Reeder, T. & Schlief, R. (1993). AraC protein can activate transcription from only one position and when pointed in only one direction. J. Mol. Biol. 231, 205-218.
25. Smith, T. L. & Sauer, R. T. (1995). P22 Arc repressor: Role of cooperativity in repression and binding to operators with altered half-site spacing. J. Mol. Biol. 249, 729-742.
26. Smith, T. L. & Sauer, R. T. (1996). Dual regulation of open-complex formation and promoter clearance by Arc explains a novel repressor to activator switch. Proc. Natl Acad. Sci. USA, 93, 8868-8872.
27. Susskind, M. M. & Youderian, P. (1983). Bacteriophage P22 antirepressor and its control. In Lambda II (Hendrix, R. W., et al., ed.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
28. Vershon, A. K., Liao, S.-M., McClure, W. R. & Sauer, R. T. (1987a). Bacteriophage P22 Mnt repressor: DNA binding and effects on transcription in vitro. J. Mol. Biol. 195, 311-322.
29. Vershon, A. K., Liao, S.-M., McClure, W. R. & Sauer, R. T. (1987b). Interaction of the bacteriophage P22 Arc repressor with operator DNA. J. Mol. Biol. 195, 323-331.
30. Vershon, A. K., Kelley, R. D. & Sauer, R. T. (1989). Sequence-specific binding of Arc repressor to DNA. J. Biol. Chem. 264, 3267-3273.
31. Waldburger, C. D. & Sauer, R. T. (1995). Domains of Mnt repressor: roles in tetramer formation, protein stability, and operator DNA binding. Biochemistry, 34, 13109-13116.
32. Zhou, Y., Busby, S. & Ebright, R. H. (1993a). Identification of the functional subunit of a dimeric transcription activator protein by use of oriented heterodimers. Cell, 73, 375-379.
33. Zhou, Y., Merkel, T. J. & Ebright, R. H. (1994a). Characterization of the activating region of Escherichia coli catabolite gene activator protein (CAP). II. Role at class I and class II CAP-dependent promoters. J. Mol. Biol. 243, 603-610.
34. Zhou, Y., Pendergrast, P. S., Bell, A., Williams, R., Busby, S. & Ebright, R. H. (1994b). The functional subunit of a dimeric transcription activator protein depends on promoter architecture. EMBO J. 13, 4549-4557.
35. Zhou, Y., Zhang, X. & Ebright, R. H. (1993b). Identification of the activating region of catabolite gene activator protein (CAP). Isolation and characterization of mutants of CAP specifically defective in transcription activation. Proc. Natl Acad. Sci. USA, 90, 6081-6085.