Preparation and in-vitro evaluation of nifedipine loaded albumin microspheres cross-linked by different glutaraldehyde concentrations

International Journal of Pharmaceutics

Volumn 144, Issue 2, 1996, Pages 241-245

  Chuo, Wen Ho ^a   Tsai, Tong Rong ^a   Hsu, Shu Hui ^a   Cham, Thau Ming ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bovine serum albumin; Glutaraldehyde; Microspheres; Nifedipine; Release models

Indexed keywords

BOVINE SERUM ALBUMIN; GLUTARALDEHYDE; MICROSPHERE; NIFEDIPINE;

ARTICLE; BIODEGRADATION; CROSS LINKING; DRUG RELEASE; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION;

EID: 0030606096     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04742-4     Document Type: Article

References (15)

1. Abdullah, M.E. and Al-Khamis, K.I., Microcomputer program for the assessment of one-way, two-way and factorial analysis of variance in pharmaceutical data. Comput. Methods. Prog. Biomed., 41 (1993) 131-133.
2. Benita, S., Barkai, A. and Pathak, Y.V., Effect of drug loading extent on the in vitro release kinetic behavior of nifedipine from polyacrylate microspheres. J. Controlled Release, 12 (1990) 213-222.
3. Braunwald, E., Mechanism of action of calcium-channel-blocking agents. N. Engl. J. Med., 307 (26) (1982) 1618-1627.
4. Chandy, T. and Sharma, C.P., Chitosan beads and granules for oral sustained delivery of nifedipine: in vitro studies. Biomat., 13 (13) (1992) 949-952.
5. Chuo, W.H., Tsai, T.R., Hsu, S.H. and Cham, T.M., Development of nifedipine-loaded albumin microspheres using a statistical factorial design. Int. J. Pharm., 134 (1996) 247-251.
6. Echizen, H. and Eichelbaum, M., Clinical pharmacokinetics of verapamil, nifedipine and diltiazem. Clin. Pharmacokinet., 11 (1986) 425-449.
7. Foster, T.S., Hamann, S.R., Richards, V.R., Bryant, P.J., Graves, D.A. and McAllister, R.G., Nifedipine kinetics and bioavailability after single intravenous and oral doses in normal subjects. J. Clin. Pharmacol., 23 (1983) 161-170.
8. Henry, P.D., Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. Am. J. Cardiol., 46 (6) (1980) 1047-1058.
9. Kohri, N., Katsumi, M., Arita, T., Shimono, H., Nomura, A. and Yasuda, H., Release characteristics of nifedipine sustained-release granules in vitro and in healthy subjects. Chem. Pharm. Bull., 35 (6) (1987) 2504-2509.
10. Leucuta, S.E., Controlled release of nifedipine from gelatin microspheres and microcapsules: in vitro kinetics and pharmacokinetics in man. J. Microencapsulation, 7(2) (1990) 209-217.
11. Pal, S., Khazanchi, R.K. and Moudgil K., An experimental study on the effect of nifedipine on ischaemic skin flap survival in rats. Br. J. Plast. Surg., 44 (1991) 299-301.
12. Scheinman, M.M. and Hess, D.S., New antiarrhythmic drugs. Am. J. Surg., 145 (6) (1983) 724-732.
13. Sheu, M.T., Moustafa, M.A. and Sokoloski, T.D., Entrapment of bioactive compounds within native albumin beads: II. Effects of rate and extent of crosslinking on microbead properties. J. Parenteral Sci. Tech., 40 (6) (1986) 253-258.
14. Sugimoto, I., Sasaki, K., Kuchiki, A., Ishihara, T. and Nakagawa, H., Stability and bioavailability of nifedipine in fine granules. Chem. Pharm. Bull., 30 (12) (1982) 4479-7788.
15. Vural, I., Kas, H.S., Hincal, A.A. and Cave, G., Cyclophosphamide loaded albumin microspheres II. Release characteristics. J. Microencapsulation, 7 (4) (1990) 511-516.