Autoregulation of androgen receptor in rat ventral prostate: involvement of c-fos as a negative regulator

Molecular and Cellular Endocrinology

Volumn 124, Issue 1-2, 1996, Pages 111-120

  Mora, Gloria R ^a   Mahesh, Virendra B ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Age; Androgen receptor; Androgen receptor mRNA; c fos; c fos mRNA; Cycloheximide; Rat ventral prostate

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR;

ANIMAL TISSUE; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; MALE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROSTATE VENTRAL LOBE; RAT;

EID: 0030606092     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(96)03939-1     Document Type: Article

References (42)

1. [1] Rundlett, S.E., Wu, X.-P. and Miesfeld, R.L. (1990) Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation. Mol. Endocrinol. 4, 708-714.
2. [2] Quarmby, V.E., Jarbrough, W.G., Lubahn, D.B., French, F.S. and Wilson, E.M. (1990) Autologous down-regulation of androgen receptor messenger ribonucleic acid. Mol. Endocrinol. 4, 22-28.
3. [3] Krongrad, A., Wilson, C.M., Wilson, J.D., Allman, D.R. and McPhaul, M.J. (1991) Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells. Mol. Cell. Endocrinol. 76, 79-88.
4. [4] Shan, L.X., Rodriguez, M.C. and Janne, O. (1990) Regulation of androgen receptor protein and mRNA concentrations by androgens in rat ventral prostate and seminal vesicles and in human hepatoma cells. Mol. Endocrinol. 4, 1636-1646.
5. [5] Wolf, D.A., Herzinger, T., Hermeking, H., Blaschke, D. and Horz, W. (1993) Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgens. Mol. Endocrinol. 7, 924-936.
6. [6] Mizokami, A., Yeh, S.-Y. and Chang, C. (1994) Identification of 3′,5′-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter. Mol. Endocrinol. 8, 77-88.
7. [7] Grossmann, M.E., Lindzey, J., Kumar, M.V. and Tindall, D.J. (1994) The mouse androgen receptor is suppressed by the 5′-untranslated region of the gene. Mol. Endocrinol. 8, 448-455.
8. [8] Grossmann, M.E. and Tindall, D.J. (1995) The androgen receptor is transcriptionally suppressed by proteins that bind single-stranded DNA. J. Biol. Chem. 270, 10968-10975.
9. [9] Mizokami, A. and Chang, C. (1994) Induction of translation by the 5′-untranslated region of human androgen receptor mRNA. J. Biol. Chem. 269, 25655-25659.
10. [10] Burnstein, K.L., Maiorino, C.A., Dai, J.L., Cameron, D.J. (1995) Androgen and glucocorticoid regulation of androgen receptor cDNA expression. Mol. Cell. Endocrinol. 115, 177-186.
11. [11] Kaneko, K.J., Furlow, J.D. and Gorski, J. (1993) Involvement of the coding sequence for the estrogen receptor gene in autologous ligand-dependent down-regulation. Mol. Endocrinol. 7, 879-888.
12. [12] Burnstein, K.L., Jewell, C.M., Sar, M. and Cidlowski, J.A. (1994) Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormone-inducible receptor messenger RNA down-regulation through multiple mechanisms. Mol. Endocrinol. 8, 1764-1773.
13. [13] Schuchard, M., Landers, J.P., Sandhu, N.P. and Spelsberg, T.C. (1993) Steroid hormone regulation of nuclear proto-oncogenes, Endocr. Rev. 14, 659-669.
14. [14] Wolf, D., Kohlhuber, F., Schulz, P., Fittler, F. and Eick, D. (1992) Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone. Br. J. Cancer 65, 376-382.
15. [15] Buttyan, R., Zakeri, Z., Lockshin, R. and Wolgemuth, D. (1988) Cascade induction of c-fos, c-myc and heat shock 70 K transcripts during regression of the rat ventral prostate gland. Mol. Endocrinol. 2, 650-657.
16. [16] Katz, A.E., Benson, M.C., Wise, G.J., Olsson, C.A., Bandyk, M.G., Sawczuk, I.S., Tomashefsky, P. and Buttyan, R. (1989) Gene activity during the early phase of androgen-stimulated rat prostate regrowth. Cancer Res. 49, 5889-5894.
17. [17] Mora, G., Prins, G. and Mahesh, V.B. (1996) Testosterone regulation of the androgen receptor is protein synthesis mediated. J. Steroid Biochem. Mol. Biol. (in Press).
18. [18] Song, C.S., Rao, T.R., Demyan, W.F., Mancini, M.A., Chatterjee, B. and Roy, A.K. (1991) Androgen receptor messenger ribonucleic acid (mRNA) in the rat liver: changes in mRNA levels during maturation, aging, and calorie restriction. Endocrinol. 128, 349-356.
19. [19] Supakar, P.C., Song, C.S., Jung, M.H., Slomczynska, M.A., Kim, J.-M., Vellanoweth, R.L., Chatterjee, B. and Roy, A.K. (1993) A novel regulatory element associated with age-dependent expression of the rat androgen receptor gene. J. Biol. Chem. 268, 26400-26408.
20. [20] Steinsapir, J., Evans, A.C., Bryhan, M. and Muldoon, T.G. (1985) Androge receptors dynamics in the rat ventral prostate. Biochem. Biophys. Acta 842, 1-11.
21. [21] Sugimura, Y., Cunha, G.R. and Donjacour, A.A. (1986) Morphogenesis of ductal networks in the mouse prostate. Biol. Reprod. 34, 961-971.
22. [22] Prins, J., Birch, L. and Greene, G. (1991) Androgen receptor localization in different cell types of the adult rat prostate. Endocrinol. 129, 3187-3199.
23. +)RNA on oligo(dT) cellulose In: Basic Methods in Molecular Biology Section 11-3, pp. 139-142.
24. [24] Carmichael, G.G. and McMaster, G.K. (1980) The analysis of nucleic acids in gels using glyoxal and acridine orange. Methods Enzymol. 65, 380-391.
25. [25] Bradford, M. (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
26. [26] Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
27. [27] Blok, L.J., Bartlett, J.M.S., Bolt-de Vries, J., Themmen, A.P.N., Brinkmann, A.O., Weinbauer, G.F., Nieschlag, E. and Grootegoed, J.A. (1992) Effect of testosterone deprivation on expression of the androgen receptor in rat prostate, epididymis and testis. Int. J. Androl. 15, 182-198.
28. [28] Burguess, L.H. and Handa, R.J. (1993) Hormonal regulation of androgen receptor mRNA in the brain and anterior pituitary gland of the male rat. Mol. Brain Res. 19, 31-38.
29. [29] Greenstein, B.D. (1979) Androgen receptors in the rat brain, anterior pituitary gland and ventral prostate gland: effects of orchidectomy and aging. J. Endocrinol. 81, 75-81.
30. [30] Prins, G. and Birch, L. (1993) Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement. Endocrinol. 132, 169-178.
31. [31] Prins, G.S. and Woodham, C. (1995) Autologous regulation of androgen receptor mRNA in the separate lobes of the rat prostate gland. Biol. Reprod. 53, 609-619.
32. [32] Franza, Jr. B.R., Rauscher, III F.J., Josephs, S.F. and Curran, T. (1988) The fos complex and fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science 239, 1150-1153.
33. [33] Distel, R.J., Ro, H.-S., Rosen, B.S., Groves, D.L. and Spiegelman, B.M. (1987) Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell 49, 835-844.
34. [34] Diamond, M.I., Miner, J.N., Yoshinaga, S.K. and Yamamoto, K.R. (1990) Transcription factor interactions: Selectors of positive or negative regulation from a single DNA element. Science 249, 1266-1272.
35. [35] Greenberg, M.E. and Ziff, E.B. (1984) Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 311, 433-438.
36. [36] Edwards, D.R. and Mahadevan, L.C. (1992) Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors. EMBO J. 11, 2415-2424.
37. [37] Lucibello, F.C., Slater, E.P., Jooss, K.U., Beato, M. and Müller, R. (1990) Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB. EMBO J. 9, 2827-2837.
38. [38] Jonat, C., Rahmsdorf, H.J., Park, K.-K., Cato, A.C.B., Gebel, S., Ponta, H. and Herrlich, P. (1990) Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62, 1189-1204.
39. [39] Yang-Yen, H.-F., Zhang, X.-K, Graupner, G., Tzukerman, M., Sakamoto, B., Karin, M. and Pfahl, M. (1991) Antagonism between retinoic acid and AP-1: implications for tumor promotion and inflammation. New Biol. 3, 1206-1219.
40. [40] Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T.J., Drouin, J. and Karin, M. (1990) Transcriptional interference between c-jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62, 1205-1215.
41. [41] Steinsapir, J., Socci, R. and Reinach, P. (1991) Effects of androgen on intracellular calcium of LNCaP cells. Biochem. Biophys. Res. Commun. 179, 90-96.
42. [42] Gong, Y., Blok, L.J., Perry, J.E., Lindzey, J.K. and Tindall, D.J. (1995) Calcium regulation of androgen receptor expression in the human prostate cancer cell line LNCaP. Endocrinol. 136, 2172-2178.