Formylcolchicine bound to lactosaminated serum albumin is a more active antifibrotic agent than free colchicine

Clinica Chimica Acta

Volumn 254, Issue 2, 1996, Pages 149-157

  Palmerini, C A ^a,b   Saccardi, C ^a   Floridi, A ^a   Arienti, G ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b Dipto di Biol Cell e Molecolare   (Italy)

Author keywords

Carbon tetrachloride; Colchicine; Formylated colchicine; Hydroxyproline; Lactosaminated serum albumin; Liver fibrosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; COLCHICINE; COLLAGEN; GAMMA GLUTAMYLTRANSFERASE; LACTALBUMIN;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; HISTOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030606026     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-8981(96)06381-4     Document Type: Article

References (18)

1. [1] Wu J, Danielsson A. Inhibition of hepatic fibrogenesis: a review of pharmacological candidates. Scand J Gastroenterol 1994;29:385-391.
2. [2] Ramond MJ, Rueff B, Benhamou JP. Medical treatment for alcoholic liver disease. Baillière's Clin Gastroenterol 1993;7:697-716.
3. [3] Kershenobich D, Uribe M, Suàrez GI, Mata JM, Pérez-Tamayo R, Rojkind M. Treatment of cirrhosis with colchicine. A double-blind randomized study. Gastroenterology 1979;77:532-536.
4. [4] Rojkind M, Kershenobich D. Effect of colchicine on collagen, albumin and transferrin synthesis by cirrhotic rat liver slices. Biochim Biophys Acta 1979;378:415-423.
5. [5] Solis-Herruzo JA, De Gando M, Ferrer MP, Hernandez-Munoz I, Fernandez-Boya B, De la Torre MP, Munoz-Yague MT. Reversal of carbon tetrachloride induced changes in microviscosity and lipid composition of liver plasma membrane by colchicine in rats. Gut 1993;34:1438-1442.
6. [6] Poo JL, Feldman G, Moreau A, Gaudin C, Lebrec D. Early colchicine administration reduces hepatic fibrosis and portal hypertension in rats with bile duct ligation. J Hepatol 1993;19:90-94.
7. [7] Tanner MS, Jackson D, Mowat AP. Hepatic collagen synthesis in a rat model of cirrhosis, and its modifications by colchicine. J Pathol 1981;135:179-187.
8. [8] Rudi J, Raedsch R, Gerteis C, Schlanker T, Plachky J, Walter-Sack I, Sabouraud A, Shermann JM, Kommerell B. Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease after oral administration of a single dose and after long-term treatment. Scand J Gastroenterol 1994;29:346-351.
9. [9] Buys CHCM, De Jong ASH, Bouma JMCV, Cruber M. Rapid uptake by liver sinusoidal cells of serum albumin modified with retention of its compact conformation. Biochim Biophys Acta 1975;392:95-100.
10. [10] Ashwell G, Hartford J. Carbohydrate-specific receptors of the liver. Annu Rev Biochem 1982;51:531-554.
11. [11] Palmerini CA, Floridi A, Arienti G. Derivatives of colchicine preferentially taken up by the liver: an approach to the treatment of liver fibrosis. Biotechnol Appl Biochem 1995;21:15-22.
12. [12] Du Bois M, Gilles KA, Hamilton JK, Repers PA, Smith F. Colorimetric method for determination of sugars and related substances. Anal Chem 1956;28:350-358.
13. [13] Field R. The rapid determination of amino groups with TNBS. Methods Enzymol 1972;25:464-468.
14. [14] Von Georges M, Blade Font A, Bardoneschi R. Substitution am C-1 des Colchicins. Justus Liebigs-Annalen Chemie 1963;105:662-674.
15. [15] Schwartz BA, Gray GR. Proteins containing reductively aminated disaccharides. Synthesis and chemical characterisation. Arch Biochem Biophys 1977;181:542-549.
16. [16] Palmerini CA, Vedovelli A, Morelli A, Fini C, Floridi A. Analysis of acid-soluble hydroxyproline, free proline and collagen-bound hydroxyproline in rat liver by high performance liquid chromatography with pre-column derivatization. J Liq Chromatogr 1985;8:1853-1868.
17. [17] Batts KP, Ludwig J. Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol 1995;19:1409-1417.
18. [18] Chevallier M, Guerret S, Chossegros P, Gerard F Grimaud JA. A histological semi-quantitative scoring system for evaluation of hepatic fibrosis in the needle liver biopsy specimens: comparison with morphometric studies. Hepatology 1994;20:349-355.