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Volumn 37, Issue 31, 1996, Pages 5479-5482

Design and synthesis of a cocaine-diamide hapten for vaccine development

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE DERIVATIVE; HAPTEN; VACCINE;

EID: 0030605861     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01170-7     Document Type: Article
Times cited : (22)

References (31)
  • 1
    • 0003703489 scopus 로고
    • Rockville, MD: U. S. Department of Health and Human Services
    • 1. (a) National Institute on Drug Abuse, Division of Epidemiology and Prevention Research. National Household Survey on Drug Abuse: Population Estimates 1990. Rockville, MD: U. S. Department of Health and Human Services, 1991.
    • (1991) National Household Survey on Drug Abuse: Population Estimates 1990
  • 25
    • 0001555867 scopus 로고
    • The (+)-isomer corresponds to the configuration of the desired natural (-)-cocaine framework
    • 16. (a) Findlay, S. P., J. Org. Chem. 1957, 22, 1385. The (+)-isomer corresponds to the configuration of the desired natural (-)-cocaine framework.
    • (1957) J. Org. Chem. , vol.22 , pp. 1385
    • Findlay, S.P.1
  • 26
    • 0019945851 scopus 로고
    • These workers report an alternative large scale preparation of racemic 7
    • (b) Carroll, F. I.; Coleman, M. L.; Lewin, A. H. J. Org. Chem. 1982, 47, 13. These workers report an alternative large scale preparation of racemic 7.
    • (1982) J. Org. Chem. , vol.47 , pp. 13
    • Carroll, F.I.1    Coleman, M.L.2    Lewin, A.H.3
  • 31
    • 85030207783 scopus 로고    scopus 로고
    • note
    • 16d of the optical rotations of (1R)-7 and (1S)-7. In our hands, a value of +26.6° was found for the R isomer that could only be obtained for a solution observed within 4 minutes of preparation. We found that aged solutions in methanol had lesser rotations (absolute value) due to epimerization at C-2. For (1R)-7, an equilibrium value of +17.4° was attained after 30 minutes. Hence, we compared this value to that for material having 99% ee.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.