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31
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85030207783
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note
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16d of the optical rotations of (1R)-7 and (1S)-7. In our hands, a value of +26.6° was found for the R isomer that could only be obtained for a solution observed within 4 minutes of preparation. We found that aged solutions in methanol had lesser rotations (absolute value) due to epimerization at C-2. For (1R)-7, an equilibrium value of +17.4° was attained after 30 minutes. Hence, we compared this value to that for material having 99% ee.
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