DNA-dependent protein kinase defects are linked to deficiencies in DNA repair and V(D)J recombination

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 351, Issue 1336, 1996, Pages 173-179

  Finnie, Nicholas J ^a  

^a WELLCOME CRC INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; DNA POLYMERASE; PROTEIN SERINE THREONINE KINASE; RECOMBINASE;

ANIMAL; DNA REPAIR; GENE REARRANGEMENT; GENETICS; PHYSIOLOGY; REVIEW;

ANIMALS; DNA NUCLEOTIDYLTRANSFERASES; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; GENE REARRANGEMENT, T-LYMPHOCYTE; PROTEIN-SERINE-THREONINE KINASES; VDJ RECOMBINASES;

EID: 0030605405     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.1996.0014     Document Type: Article

References (41)

1. Anderson, C. W. 1993 DNA damage and the DNA-activated protein kinase. Trends biochem. Sci. 18, 433-437.
2. Anderson, C. W. & Lees-Miller, S. P. 1992 The nuclear serine/threonine protein kinase DNA-PK. Crit. Rev. Eukary. Gene Express. 2, 283-314.
3. Bannister, A. J., Gottlieb, T. M., Kouzarides, T. & Jackson, S. P. 1993 c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. Nucl. Acids Res. 21, 1289-1295.
4. Biedermann, K. A., Sun, J., Giaccia, A. J., Tosto, L. M. & Brown, J. M. 1991 seid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. natn Acad. Sci. U.S.A. 88, 1394-1397.
5. Blunt, T., Finnie, N. J., Taccioli, G. E., Smith, G. C. M., Demengeot, J., Gottlieb, T. M., Mizuta, R., Varghese, A. J., Alt, F. W., Jeggo, P. A. & Jackson, S. P. 1995 Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823.
6. Boubnov, N. V., Hall, K. T., Wills, Z., Lee, S. E., He, D. M., Benjamin, D. M., Pulaski, C. R., Pulaski, B., Pulaski, H., Reeves, W., Hendrickson, E. A. & Weaver, D. 1995 Complementation of ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants of the p86 Ku autoantigen. Proc. natn Acad. Sci. U.S.A. 92, 890-894.
7. Brush, G. S., Anderson, C. W. & Kelly, T. J. 1994 The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. Proc. natn Acad. Sci. U.S.A. 91, 12520-12524.
8. Carter, T., Vancurova, I., Sun, I., Lou, W. & DeLeon, S. 1990 A DNA-activated protein kinase from HeLa cell nuclei. Molec. Cell. Biol. 10, 6460-6471.
9. Dvir, A., Stein, L. Y., Galore, B. L. & Dynan, W. S. 1993 Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. J. biol. Chem. 268, 10440-10447.
10. Falzon, M., Fewell, J. W. & Kuff, E. L. 1993 EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single-to double-strand transition in DNA. J. biol. Chem. 268, 10546-10552.
11. Finnie, N., Gottlieb, T., Hartley, K. & Jackson, S. P. 1993 Transcription factor phosphorylation by the DNA-dependent protein kinase. Biochem. Soc. Trans. 21, 930-935.
12. Finnie, N. J., Gottlieb, T. M., Blunt, T., Jeggo, P. & Jackson, S. P. 1995 DNA-PK activity is absent in xrs-6 cells; implications for site-specific recombination and DNA double-strand break repair. Proc. natn Acad. Sci. U.S.A. 92, 320-324.
13. Fulop, G. M. & Phillips, R. A. 1990 The scid mutation in mice causes a general defect in DNA repair. Nature, Lond. 347, 479-482.
14. Getts, R. C. & Stamato, T. D. 1994 Absence of a Ku-like DNA end-binding activity in the xrs double-strand DNA repair deficient mutant. J. biol. Chem. 269, 15981-15984.
15. Giaccia, A., Weinstein, R., Hu, K. J. & Stamato, T. D. 1985 Cell cycle-dependent repair of double-stranded DNA breaks in a gamma-ray sensitive Chinese hamster cell. Somat. Cell. molec. Genet. 11, 485-491.
16. Gottlieb, T. M. & Jackson, S. P. 1993 The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142.
17. Gottlieb, T. M. & Jackson, S. P. 1994 Protein kinases and DNA damage. Trends biochem. Sci. 19, 500-503.
18. Hartley, K. O., Gell, D., Smith, G. C. M., Zhang, H., Divecha, N., Connelly, M. A., Admon, A., Lees-Miller, S. P., Anderson, C. W. & Jackson, S. P. 1995 DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849-856.
19. Hendrickson, E. A., Qin, X. -Q., Bump, E. A., Schatz, D. G., Oettinger, M. & Weaver, D. T. 1991 A link between double-strand break-related repair and V(D)J recombination: the seid mutation. Proc. natn Acad. Sci. U.S.A. 88, 4061-4065.
20. Jackson, S. P., Gottlieb, T. & Hartley, K. 1993 Phosphorylation of transcription factor Sp1 by the DNA-dependent protein kinase. Adv. Sec. Messeng. Phosphopro. Res. 28, 279-286.
21. Jackson, S. P., MacDonald, J. J., Lees-Miller, S. & Tjian, R. 1990 GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 63, 155-165.
22. Kemp, L. M., Sedgwick, S. G. & Jeggo, P. A. 1984 X-ray sensitive mutants of Chinese hamster ovary cells defective in double-stranded break rejoining. Mut. Res. 132, 189-196.
23. Kirchgessner, C. U., Patil, C. K., Evans, J. W., Carter, T. & Brown, J. M. 1995 DNA dependent kinase (p350)is a candidate gene for murine scid defect. Science, Wash. 267, 1178-1182.
24. Kuhn, A., Gottlieb, T. M., Jackson, S. P. & Grummt, I. 1995 DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I. Genes Dev. 9, 193-203.
25. Labhart, P. 1995 DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I. Proc. natn Acad. Sci. U.S.A. 92, 2934-2938.
26. Lees-Miller, S. P., Chen, Y. -R. & Anderson, C. W. 1990 Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53 and the human Ku autoantigen. Molec. Cell. Biol. 10, 6472-6481.
27. Lees-Miller, S. P., Sakaguchi, K., Ullrich, S. J., Appella, E. & Anderson, C. W. 1992 Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Molec. Cell. Biol. 12, 5041-5049.
28. cs) maps to the scid locus. Proc. natn. Acad. Sci. U.S.A. 92. (In the press.)
29. Morozov, V. E., Falzon, M., Anderson, C. W. & Kuff, E. L. 1994 DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. biol. Chem. 269, 16684-16688.
30. Oettinger, M. A., Schatz, D. G., Gorka, C. & Baltimore, D. 1990 RAG 1 and RAG 2, adjacent genes that synergistically activate V(D)J recombination. Science, Wash. 248, 1517-1523.
31. Paillard, S. & Strauss, F. 1991 Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucl. Acids. Res. 19, 5619-5624.
32. Pan, Z.-Q., Amin, A. A., Gibbs, E., Niu, H. & Hurwitz, J. 1994 Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalysed by cdk-cyclin 1 complex and DNA-dependent protein kinase. Proc. natn Acad. Sci. U.S.A. 91, 8343-8347.
33. Pergola, F., Zdzienicka, M. Z. & Lieber, M. R. 1993 V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Molec. Cell. Biol. 13, 3464-3471.
34. Rathmell, W. K. & Chu, G. 1994 Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Proc. natn Acad. Sci. U.S.A. 91, 7623-7627.
35. Schuler, W., Weiler, I. J., Schuler, A., Phillips, R. A., Rosenberg, N., Mak, T. W., Kearney, J. F., Perry, R. P. & Bosma, J. J. 1986 Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46, 963-972.
36. Sipley, J. D., Mennenger, J., Hartley, K. O., Ward, D., Jackson, S. P. & Anderson, C. W. 1995 The gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8. Proc. natn Acad. Sci. U.S.A. 92, 7515-7519.
37. Smider, V., Rathmell, W. K., Lieber, M. R. & Chu, G. 1994 Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science, Wash. 266, 288-291.
38. Taccioli, G. E., Gottlieb, T. M., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A. R., Alt, F. W., Jackson, S. P. & Jeggo, P. A. 1994 Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science, Wash. 265, 1442-1445.
39. Taccioli, G. E., Rathbun, G., Oltz, E., Stamato, T., Jeggo, P. A. & Alt, F. W. 1993 Impairment of V(D)J recombination in double-stranded break repair mutants. Science, Wash. 260, 207-210.
40. Walker, A. I., Hunt, T., Jackson, R. J. & Anderson, C. W. 1985 Double-stranded DNA induces the phosphorylation of several proteins including the 90000 mol. wt. heat-shock protein in animal cell extracts. EMBO J. 4, 139-145.
41. Whitmore, G. F., Varghese, A. J. & Gulyas, S. 1989 Cell cycle responses of two X-ray sensitive mutants defective in DNA repair. Int. J. radiat. Biol. 56, 657-665.