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The synthesis of 3-substituted isocoumarins by acylation of 6-methoxytoluate esters with N-methoxy-N-methyl-carboxamides followed by cyclisation of the resulting ketoesters has been reported
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9. The synthesis of 3-substituted isocoumarins by acylation of 6-methoxytoluate esters with N-methoxy-N-methyl-carboxamides followed by cyclisation of the resulting ketoesters has been reported: Lewis, C. N.; Spargo, P. L.; Staunton, J., Synthesis, 1986, 944.
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Condensation of o-toluamide anions with aromatic aldehydes followed by base hydrolysis gives 3-aryl-3,4-dihydroisocoumarins in modest yield
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10. Condensation of o-toluamide anions with aromatic aldehydes followed by base hydrolysis gives 3-aryl-3,4-dihydroisocoumarins in modest yield: Watanabe, M.; Sahara, M.; Kubo, M.; Furukawa, S.; Billedeau, R. J.; Snieckus, V., J. Org. Chem., 1984, 49, 742.
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85030284500
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note
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11. All new compounds gave satisfactory spectroscopic and analytical data which will be reported in full elsewhere.
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12
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85030289609
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note
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2]bromoacetic acid.
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14
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The e.e. was determined after ethanolysis of (12) and conversion to the (S)-(-)-MTPA ester
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16. The e.e. was determined after ethanolysis of (12) and conversion to the (S)-(-)-MTPA ester: Carreira, E. M.; Singer, R. A.; Lee, W., J. Am. Chem. Soc., 1994, 116, 8837.
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The acid catalysed hydrolysis proceeds considerably faster than base catalysed hydrolysis reported in similar systems
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23. The acid catalysed hydrolysis proceeds considerably faster than base catalysed hydrolysis reported in similar systems : Salvadori, P.; Superchi, S.; Minutolo, F., J. Org. Chem., 1996, 61, 4190.
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