Liquid chromatography/electrospray ionization tandem mass spectroscopy (LC/ESI MS/MS) analysis of 1,2-epoxybutene adducts of purine deoxynucleosides

Toxicology

Volumn 113, Issue 1-3, 1996, Pages 331-335

  Kambouris, Sara J ^a,b   Chaudhary, Ajai K ^b   Blair, Ian A ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

1,2 epoxybutene; adducts; liquid chromatography electrospray ionization tandem mass spectroscopy (LC ESI MS MS); purine deoxynucleosides

Indexed keywords

BUTADIENE DIEPOXIDE; DEOXYRIBONUCLEOTIDE;

CONFERENCE PAPER; COW; DNA ADDUCT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; THYMUS;

EID: 0030605142     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)03468-3     Document Type: Conference Paper

References (14)

1. Blair, I.A. (1994) Mass-spectrometry in drug disposition and pharmacokinetics. In: P.G. Welling and L.P. Balant (Eds), Pharmacokinetics of Drugs - Handbook of Experimental Pharmacology, Springer-Verlag, Heidelberg, pp. 41-84.
2. Bond, J.A., Dahl, A.R., Henderson, R.F., Dutcher, J.S., Mauderly, J.L. and Birnbaum, L.S. (1986) Species differences in the disposition of inhaled butadiene. Toxicol. App. Pharmacol. 84, 617-627.
3. Chaudhary, A.K., Nokubo, M., Oglesby, T.D., Marnett, L.J. and Blair, I.A. (1995a) Characterization of endogenous DNA adducts by liquid chromatography/electrospray ionization/tandem mass spectrometry. J. Mass Spectrom. 30, 1157-1166.
4. Chaudhary, A.K., Reddy, G.R., Compton, L.J., Marnett, L.J. and Blair, I.A. (1995b) Analysis of DNA base modifications in oligonucleotides using LC/ES MS. 43rd ASMS Conference: Mass Spectrometry and Allied Topics, Atlanta (Abstract).
5. Cheng, X. and Ruth, J.A. (1993) A simplified methodology for quantitation of butadiene metabolites. Application to the study of 1,3-butadiene metabolism by rat liver microsomes. Drug Metab. Dispos. 21, 121-124.
6. Citti, L., Gervasi, P.G., Turchi, G., Bellucci, G. and Bianchini, R. (1984) The reaction of 3,4-epoxy-1-butene with deoxyguanosine and DNA in vitro: synthesis and characterization of the main adducts. Carcinogenesis 5, 47-52.
7. Csanády, G.A., Guengerich, F.P. and Bond, J.A. (1992) Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. Carcinogenesis 13, 1143-1153.
8. Duescher, R.J. and Elfarra, A.A. (1992) 1,3-Butadiene oxidation by human myeloperoxidase. Role of chloride ion in catalysis of divergent pathways. J. Biol. Chem. 267, 19859-19865.
9. Jajoo, H.K., Burcham, P.C., Goda, Y., Blair, I.A. and Marnett, L.J. (1992) A thermospray liquid chromatography/ mass spectrometry method for analysis of human urine for the major malondialdehyde-guanine adduct. Chem. Res. Toxicol. 5, 870-875.
10. Jelitto, B., Vangala, R.R. and Laib, R.J. (1989) Species differences in DNA damage by butadiene: role of diepoxybutane. Arch. Toxicol. 13, 246-249.
11. Kambouris, S.J., Chaudhary, A.K. and Blair, I.A. (1995a) Characterization of 1,2,3,4-diepoxybutane purine adducts using LC/ESI/MS/MS. 43rd ASMS Conference: Mass Spectrometry and Allied Topics, Atlanta (Abstract)
12. Kambouris, S.J., Chaudhary, A.K. and Blair, I.A. (1995b) LC/ESI/MS/MS analysis of 1,2,3,4-diepoxybutane-adducts of purine nucleosides. Health Effects Institute, 5th Annual Conference, Chicago (Abstract),
13. Kohn, M.C. and Melnick, R.L. (1993) Species differences in the production and clearance of 1,3-butadiene metabolites: a mechanistic model indicates predominantly physiological, not biochemical, control. Carcinogenesis 14, 619-628.
14. Kowalski, E.M., Chaudhary, A.K. and Blair, I.A. (1995) Analysis of hydroxyl radical modifications of DNA using LC/ESI/MS/MS. 43rd ASMS Conference: Mass Spectrometry and Allied Topics, Atlanta (Abstract).