Isoprene cancer risk and the time pattern of dose administration

Toxicology

Volumn 113, Issue 1-3, 1996, Pages 263-272

  Cox Jr , Louis Anthony ^a   Bird, Michael G ^b   Griffis, Larry ^c  

^a Cox Associates ^*  (United States)

^b EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^c CHEVRON ENERGY TECHNOLOGY COMPANY   (United States)

Author keywords

carcinogenesis; dose metrics; dose response modeling; isoprene; risk assessment

Indexed keywords

ISOPRENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER INCIDENCE; CANCER RISK; CARCINOGENICITY; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; HEART TUMOR; INHALATION; LYMPHOMA; MALE; MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; STOMACH TUMOR;

ANIMALIA;

EID: 0030605097     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)03455-5     Document Type: Conference Paper

References (15)

1. Andersen, P.K., Borgan, O., Gill, R.D. and Keiding, N. (1993) Statistical Models Based on Counting Processes. Springer-Verlag, New York.
2. Biggs, D., de Ville, B. and Suen, E. (1991) A method of choosing multiway partitions for classification and decision trees. J. Appl. Stat. 18, 49-62.
3. Cox Jr, L.A. (1994) Statistical Analysis of Isoprene Bioassay Data. Final Report to the International Institute of Synthetic Rubber Producers. Cox Associates, Denver, Colorado.
4. Doucet, P. and Sloep, P.B. (1992) Mathematical Modeling in the Life Sciences. Ellis-Horwcod, New York.
5. Huff, J. and Haseman, J. (1991) Long-term chemical carcinogenesis experiments for identifying potential human cancer hazards: collective database of the National Cancer Institute and the National Toxicology Program (1976-1991). Environ. Health Perspect. 96, 23-31.
6. Kolluru, R.V. (1994) Risk assessment and management, chapter 11. In: R.V. Kolluru (Ed), Environmental Strategies Handbook: A Guide to Effective Policies and Practices, McGraw-Hill, New York.
7. Kopp-Schneider, A. and Portier, C.J. (1994) A stem cell model for carcnogenesis. Math. Biosci. 120, 211-232.
8. Lin, C.C. and Segel, L.A. (1988) Mathematics Applied to Deterministic Problems in the Natural Sciences. Society for Industrial and Applied Mathematics, Philadelphia, PA.
9. Mazumdar, J. (1989) An Introduction to Mathematical Physiology and Biology. Cambridge University Press, New York.
10. Melnick, R.L., Huff, J.E., Roycroft, J.H., Chou, B.J. and Miller, R.A. (1990) Inhalation toxicology and carcinogenicity of 1,3-butadiene in B6C3F1 mice following 65 weeks of exposure. Environ. Health Perspect. 86, 27-36.
11. Moolgavkar, S.H. (1978) The multistage theory of carcinogenesis and the age distribution of cancer in man. J. Natl. Cancer Inst. 61, 49-52.
12. Peter, H., Wiegand, H-J., Filser, J.G., Bolt, H.M. and Laib, R.J. (1990) Inhalation and pharmacokinetics of isoprene in rats and mice. Environ. Health Perspect. 86, 89-92.
13. Placke, M.E. et al. (1995) Inhalation oncogenicity study of isoprene in B6C3F1 mice. Toxicology (this issue).
14. Siegel, S. (1956) Nonparametric Statistics for the Behavioral Sciences. McGraw-Hill, New York.
15. U.S. Department of Health and Human Services (USDHHS) (1986) Determining Risks to Health: Federal Policy and Practice. Appendix 6. Auburn House Publishing Company, Dover, MA.