Studies on the molecular toxicology of buta-1,3-diene and isoprene epoxides

Toxicology

Volumn 113, Issue 1-3, 1996, Pages 290-293

  Bleasdale, Christine ^a   Small, Rowena D ^a   Watson, William P ^b   Wilson, Joanne ^a   Golding, Bernard T ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b SHELL RESEARCH AND TECHNOLOGY CENTRE   (Netherlands)

Author keywords

2 ethenyl 2 methyloxirane; ethenyloxirane; nucleophile; regioselectivity

Indexed keywords

1,3 BUTADIENE; EPOXIDE; ISOPRENE;

CHEMICAL REACTION; CONFERENCE PAPER; DETOXIFICATION; INTOXICATION; PRIORITY JOURNAL;

EID: 0030605086     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)03458-0     Document Type: Conference Paper

References (4)

1. Elfarra, A.A. et al. (1995) Synthesis and characterization of N-acetyl-L-cysteine S-conjugates of butadiene monoxide and their detection and quantitation in urine of rats and mice given butadiene monoxide. Chem. Res. Toxicol. 8, 68-76.
2. Ellis, M.K. et al. (1984) Intrinsic reactivities in the alkylation of protected amino acids by (R)-and (S)-methyloxirane. J. Chem. Soc., Perkin Trans. 2, 1737-1743.
3. Gervasi, P.G. et al. (1985) Mutagenicity and chemical reactivity of epoxide intermediates of isoprene metabolism and other structurally related compounds. Mutat. Res. 156, 77-82.
4. Jaime, C. et al. (1988) Interpretation of conjugated oxiranes behavior towards nucleophiles. J. Org. Chem. 53, 139-141.