Cell size and geometry of spinal cord motoneurons in the adult cat following the intramuscular injection of adriamycin: Comparison with data from aged cats

Brain Research

Volumn 738, Issue 1, 1996, Pages 121-130

  Liu, Rong Huan ^a   Yamuy, Jack ^a   Engelhardt, John K ^a   Xi, Ming Chu ^a   Morales, Francisco R ^a   Chase, Michael H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

adriamycin; aging; cell size; doxorubicin; equivalent cylinder; intracellular recording; motoneuron; neurotoxicity

Indexed keywords

DOXORUBICIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAT; CONTROLLED STUDY; ELECTROPHYSIOLOGY; INTRACELLULAR RECORDING; INTRAMUSCULAR DRUG ADMINISTRATION; MORPHOMETRICS; MOTONEURON; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD;

EID: 0030605070     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00769-X     Document Type: Article

References (46)

1. Adinolfi A.M., Yamuy J., Morales F.R., Chase M.H. Segmental demyelination in peripheral nerves of old cats. Neurobiol. Aging. 12:1991;175-179.
2. Adinolfi A.M., Engelhardt J.K., Chirwa S.S., Morales F.R., Chase M.H. Electrophysiological and morphological changes in the masseter nerve of aged cats. Anat. Rec. 232:1992;6A.
3. Barrett J.N., Crill W.E. Specific membrane properties of cat motoneurones. J. Physiol. 239:1974;301-324.
4. Bernstein, H. and Gensler, H.L., DNA damage and aging. In B.P. Yu (Ed.), Free Radicals in Aging, CRC Press, Ann Arbor, 1993, pp. 89-122.
5. Bigotte L., Olsson Y. Cytotoxic effects of adriamycin on mouse hypoglossal neurons following retrograde axonal transport from the tongue. Acta Neuropathol. 61:1983;161-168.
6. Boegman R.J., Scarth B., Dragovic L., Robertson D.M. Neurotoxicity of adriamycin and misonidazole in the mouse. Exp. Neurol. 87:1985;1-8.
7. Burke, R.E. and Rudomin, P., Spinal neurons and synapses. In Handbook of Physiology. The Nervous System. Cellular Biology of Neurons, Vol. 1, Part 2, Am. Physiol. Soc., Bethesda, 1977, pp. 877-944.
8. Canada, A.T. and Calabrese, E.J., Free radicals, aging, and toxicology. In R.L. Cooper, J.M. Goldman, and T.J. Harbin (Eds.), Aging and Environmental Toxicology, The Johns Hopkins University Press, Baltimore, 1991, pp. 31-55.
9. Chandler S.H., Hsaic C.-F., Inoue T., Goldberg L.J. Electrophysiological properties of guinea pig trigeminal motoneurons recorded in vitro. J. Neurophysiol. 71:1994;129-145.
10. Chase M.H., Morales F.R., Boxer P.A., Fung S.J. Aging of motoneurons and synaptic processes in the cat. Exp. Neurol. 90:1985;471-478.
11. Chase M.H., Engelhardt J.K., Adinolfi A.M., Chirwa S.S. Age-dependent changes in cat masseter nerve: an electrophysiological and morphological study. Brain Res. 586:1992;279-288.
12. Cho E.-S. Toxic effects of adriamycin on the ganglia of the peripheral nervous system: a neuropathological study. J. Neuropathol. Exp. Neurol. 36:1977;907-915.
13. Degraff W., Hahn S.M., Mitchell J.B., Krishna M.C. Free radical modes of cytotoxicity of adriamycin and streptonigrin. Biochem. Pharmacol. 48:1994;1427-1435.
14. Di Marco A. Adriamycin (NSC-123127): mode and mechanism of action. Cancer Chemother. Rep. (Part 3). 6:1975;91-106.
15. Engelhardt J.K., Morales F.R., Yamuy J., Chase M.H. Cable properties of spinal cord motoneurons in adult and aged cats. J. Neurophysiol. 61:1989;194-201.
16. Engelhardt J.K., Chase M.H. Passive electrophysiological properties of aged and axotomized cat spinal cord motoneurons: the effect of cell size and electrode shunt. Neurosci. Lett. 141:1992;43-46.
17. Engelhardt J.K., Morales F.R., Castillo P.E., Pedroarena C., Pose I., Chase M.H. Experimental analysis of the method of `peeling' exponentials for measuring passive electrical properties of mammalian motoneurons. Brain Res. 675:1995;241-248.
18. England J.D., Rhee E.K., Said G., Sumner A.J. Schwann cell degeneration induced by doxorubicin (adriamycin). Brain. 111:1988;901-913.
19. England J.D., Asbury A.K., Rhee E.K., Sumner A. Lethal retrograde axoplasmic transport of doxorubicin (adriamycin) to motor neurons: a toxic motor neuronopathy. Brain. 111:1988;915-926.
20. Gotz M.E., Kunig G., Riederer P., Youdim M.B.H. Oxidative stress: free radical production in neural degeneration. Pharmacol. Ther. 63:1994;37-122.
21. Gustafsson B., Pinter M.J. Relations among passive electrical properties of lumbar α-motoneurones of the cat. J. Physiol. 356:1984;401-431.
22. Halliwell J.V., Adams P.R. Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res. 250:1982;71-92.
23. Hashizume K., Kanda K., Burke R.E. Medial gastrocnemius motor nucleus in the rat: Age-related changes in the number and size of motoneurons. J. Comp. Neurol. 269:1988;425-430.
24. Hashizume K., Kanda K. Differential effects of aging on motoneurons and peripheral nerves innervating the hindlimb and forelimb muscles of rats. Neurosci. Res. 22:1995;189-196.
25. Julka D., Sandhir R., Gill K.D. Adriamycin-induced oxidative stress in rat central nervous system. Biochem. Mol. Biol. Int. 29:1993;807-820.
26. Komiyama T., Kikuchi T., Sugiura Y. Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase. Biochem. Pharmacol. 31:1982;3651-3656.
27. Kondo A., Ohnishi A., Nagara H., Tateishi J. Neurotoxicity in primary sensory neurons of adriamycin administered through retrograde axoplasmic transport in rats. Neuropathol. Appl. Neurobiol. 13:1987;177-192.
28. Liu R.-H., Yamuy J., Xi M.-C., Morales F.R., Chase M.H. Changes in the electrophysiological properties of cat spinal motoneurons following the intramuscular injection of adriamycin compared with changes in the properties of motoneurons in aged cats. J. Neurophysiol. 74:1995;1972-1981.
29. Liu R.-H., Yamuy J., Bertolotto C., Xi M.-C., Morales F.R., Chase M.H. Adriamycin-induced changes in cell size and geometry of adult cat spinal motoneurons compared with changes in motoneurons of aged cats. Soc. Neurosci. Abstr. 21:1995;472.
30. Mann D.M.A., Yates P.O. Motor neuron disease: the nature of pathogenic mechanism. J. Neurol. Neurosurg. Psychiatry. 37:1974;1036-1046.
31. Mayer M., Westbrook G.L. A voltage-clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones. J. Physiol. 340:1983;19-45.
32. Morales F.R., Boxer P.A., Fung S.J., Chase M.H. Basic electrophysiological properties of spinal cord motoneurons during old age in the cat. J. Neurophysiol. 58:1987;180-194.
33. Olson R.D., Boerth R.C., Gerber J.G., Nies A.S. Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress. Life Sci. 29:1981;1393-1401.
34. Rall W. Time constants and electrotonic length of membrane cylinders and neurons. Biophys. J. 9:1969;1483-1508.
35. Rall W. Branching dendritic trees and motoneuron membrane resistivity. Exp. Neurol. 1:1959;491-527.
36. Rall, W., Core conductor theory and cable properties of neurons. In Handbook of Physiology. The Nervous System. Cellular Biology of Neurons, Vol. 1, Part 1, Am. Physiol. Soc., Bethesda, 1977, pp. 39-97.
37. Rall W., Burke R.E., Holmes W.R., Jack J.J.B., Redman S.J., Segev I. Matching dendritic neuron models to experimental data, Physiol. Rev. 72:1992;S159-S186.
38. Smith M.A., Sayre L.M., Monnier V.M., Perry G. Radical ageing in Alzheimer's disease. Trends Neurosci. 18:1995;172-176.
39. Spain W.J., Schwindt P.C., Crill W.E. Anomalous rectification in neurons from cat sensorimotor cortex in vitro. J. Neurophysiol. 57:1987;1555-1576.
40. Thornalley P.J., Dodd N.J.F. Free radical production from normal and adriamycin-treated rat cardiac sarcosomes. Biochem. Pharmacol. 34:1985;669-674.
41. Weindruch, R., Warner, H.R. and Starke-Reed, P.E., Future directions of free radical research in aging. In B.P. Yu (Ed.), Free Radicals in Aging, CRC Press, Ann Arbor, 1993, pp. 269-296.
42. Yamamoto T., Iwasaki Y., Konno H. Retrograde axoplasmic transport of adriamycin: An experimental form of motor neuron disease? Neurology. 34:1984;1299-1304.
43. Yamuy J., Engelhardt J.K., Morales F.R., Chase M.H. active electrophysiological properties of spinal motoneurons in aged cats following axotomy. Neurobiol. Aging. 13:1992;231-238.
44. Yamuy J., Engelhardt J.K., Morales F.R., Chase M.H. Passive electrical properties of motoneurons in aged cats following axotomy. Brain Res. 570:1992;300-306.
45. Yu, B.P., Oxidative damage by free radicals and lipid peroxidation in aging. In B.P. Yu (Ed.), Free Radicals in Aging, CRC Press, Ann Arbor, 1993, pp. 57-88.
46. Zengel J.E., Reid S.A., Sypert G.W., Munson J.B. Membrane electrical properties and prediction of motor-unit type of medial gastrocnemius motoneurons in the cat. J. Neurophysiol. 53:1985;1323-1344.