Chlorambucil and bleomycin induce mutations in the specific-locus test in female mice

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 358, Issue 1, 1996, Pages 25-35

  Russell, Liane B ^a   Hunsicker, Patricia R ^a   Shelby, M D ^b  

^a Department of Energy   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Bleomycin; Chlorambucil; Germ cell; Mouse; Mutation; Oocyte; Specific locus test

Indexed keywords

BLEOMYCIN; BLEOMYCIN SULFATE; CHLORAMBUCIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE LOCUS; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; MUTAGEN TESTING; MUTATION; MUTATION RATE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PRODUCTIVITY; SEX DIFFERENCE; SPERMATID; STATISTICS; SURVIVAL;

ANIMALIA;

EID: 0030605028     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(96)00104-2     Document Type: Article

References (24)

1. [1] Ehling, U.H. (1974) Differential spermatogenic response of mice to the induction of mutations by antineoplastic drugs, Mutation Res., 26, 285-295.
2. [2] Cattanach, B.M. (1982) Induction of specific-locus mutations in female mice by triethylenemelamine (TEM), Mutation Res., 104, 173-176.
3. [3] Ehling, U.H., and A. Neuhäuser-Klaus (1988) Induction of specific-locus mutations in female mice by 1-ethyl-1-nitrosourea and procarbazine, Mutation Res., 202, 139-146.
4. [4] Russell, W.L., P.R. Hunsicker and J.W. Bangham (1986) High resistance of mouse oocytes to mutation induction by ethylnitrosourea, Environ. Mutagen 8 (Suppl. 6), 71.
5. [5] Russell, L.B. and W.L. Russell (1992) Frequency and nature of specific-locus mutations induced in female mice by radiations and chemicals: a review. Mutation Res., 296, 107-127.
6. [6] Lyon, M.F., R.J.S. Phillips and G. Fisher (1979) Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation, Mutation Res., 63, 161-173.
7. [7] Russell, W.L. (1977) Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women, Proc. Natl. Acad. Sci. USA, 74, 3523-3527.
8. [8] Abrahamson, S. and S. Wolf (1976) Re-analysis of radiation-induced specific locus mutations in the mouse, Nature, 264, 716-719.
9. [9] Russell, L.B., P.R. Hunsicker, N.L.A. Cacheiro, J.W. Bangham, W.L. Russell and M.D. Shelby (1989) Chlorambucil effectively induces deletion mutations in mouse germ cells, Proc. Natl. Acad. Sci. USA, 86, 3704-3708.
10. [10] Rinchik, E.M., J.W. Bangham, P.R. Hunsicker, N.L.A. Cacheiro, B.S. Kwon, I.J. Jackson and L.B. Russell (1990) Genetic and molecular analysis of chlorambucil-induced germline mutations in the mouse, Proc. Natl. Acad. Sci. USA, 87, 1416-1420.
11. [11] Sudman, P.D., J.C. Rutledge, J.B. Bishop and W.M. Generoso (1992) Bleomycin: female-specific dominant lethal effects in mice, Mutation Res., 296, 143-156.
12. [12] Povirk, L.F. and M.J.F. Austin (1991) Genotoxicity of bleomycin, Mutation Res., 257, 127-143.
13. [13] Povirk, L.F., M. Hogan and N. Dattagupta (1979) Binding of bleomycin to DNA: Intercalation of the bithiazole rings, Biochemistry, 18, 96-101.
14. [14] Caporossi, D., B. Tedeschi, P. Vernole, B. Porfirio and B. Nicoletti (1989) Chromosome breakage induced by bleomycin in an ataxia telangiectasia lymphoblastoid line: correlation with fragile sites and Epstein-Barr virus DNA localization, Cytogenet. Cell Genet., 52, 180-185.
15. [15] Oakberg, E.F. (1984) Germ cell toxicity: significance in genetic and fertility effects of radiation and chemicals, Environ. Sci. Res., 31, 549-590.
16. [16] Oakberg, E.F. (1979) Timing of oocyte maturation in the mouse and its relevance to radiation-induced cell killing and mutational sensitivity, Mutation Res., 59, 39-48.
17. [17] Rinchik, E.M. (1994) Molecular genetics of the brown (b)-locus region of mouse Chromosome 4. II. Complementation analyses of lethal brown deletions, Genetics, 137, 855-865.
18. [18] Russell, L.B., P.R. Hunsicker and M.D. Shelby (1992) Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids, Mutation Res., 282, 151-158.
19. [19] Russell, L.B. (1990) Patterns of Mutational Sensitivity to Chemicals in Poststem-cell Stages of Mouse Spermatogenesis, in: M. Mendelsohn and R.J. Albertini (Eds.), Mutation and The Environment, Part C: Somatic and heritable mutations, adduction, and epidimiology, Alan Liss, NY, Progress in Clinical and Biological Research, Vol. 340C, pp. 101-113.
20. [20] Russell, L.B., K.F. Stelzner and W.L. Russell (1959) Influence of dose rate on the radiation effect on fertility of female mice, Proc. Soc. Exp. Biol. Med., 102, 471-479.
21. [21] Straume, T.T.C. Kwan, L.S. Goldstein and R.L. Dobson (1991) Measurement of neuron-induced genetic damage in mouse immature oocytes, Mutation Res., 248, 123-133.
22. [22] Russell, W.L. (1967) Repair mechanisms in radiation mutation induction in the mouse, Proc. of the 20th Brookhaven Symposia in Biology, 'Recovery and Repair Mechanisms in Radiobiology', pp. 179-189.
23. [23] Russell, L.B. (1986) Information from specific-locus mutants on the nature of induced and spontaneous mutations in the mouse, in: Genetic Toxicology of Environmental Chemicals, Part B: Genetic Effects and Applied Mutagenesis. Alan R. Liss, NY, pp. 437-447.
24. [24] Russell, L.B., W.L. Russell, E.M. Rinchik and P.R. Hunsicker (1990) Factors Affecting the Nature of Induced Mutations, in: Banbury Report 34: Biology of Mammalian Germ Cell Mutagenesis, Cold Spring Harbor Laboratory Press, NY, pp. 271-289.