32P-postlabeling of 1,3-butadiene and 4-vinyl-1-cyclohexene metabolite-DNA adducts: In vitro and in vivo applications

Toxicology

Volumn 113, Issue 1-3, 1996, Pages 341-344

  Mabon, Nathalie ^a   Randerath, Kurt ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

1,3 butadiene; 4 vinyl 1 cyclohexene; 32P postlabeling; diene diepoxides; DNA adducts; mouse skin

Indexed keywords

1,3 BUTADIENE; DIMER; EPOXIDE; PHOSPHORUS 32; 4 VINYL 1 CYCLOHEXENE DIOXIDE; 4-VINYL-1-CYCLOHEXENE DIOXIDE; BUTADIENE DIEPOXIDE; CARCINOGEN; CYCLOHEXANE DERIVATIVE; CYCLOHEXENE DERIVATIVE; VINYL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOASSAY; CONFERENCE PAPER; CONTROLLED STUDY; DNA ADDUCT; DOSE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN; TOPICAL DRUG ADMINISTRATION; ANIMAL; ARTICLE; FEMALE; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM;

ANIMALIA;

ANIMALS; CARCINOGENS; CYCLOHEXANES; CYCLOHEXENES; DNA ADDUCTS; EPOXY COMPOUNDS; FEMALE; MICE; MICE, INBRED ICR; SKIN; VINYL COMPOUNDS;

EID: 0030604920     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)03470-1     Document Type: Conference Paper

References (11)

1. Bond, J.A., Recio, L. and Andjelkovich, D. (1995) Epidemiological and mechanistic data suggest that 1,3-butadiene will not be carcinogenic to humans at exposures likely to be encountered in the environment or workplace. Carcinogenesis 16, 165-171.
2. Chhabra, R. (1989) Toxicology and carcinogenesis of 4-vinyl-1-cyclohexene diepoxide (CAS No. 106-87-6) in F344/N rats and B6C3F1 mice (dermal studies). NTP Technical Report No. 362. U.S. Department of Health and Human Services.
3. Citti, L., Gervasi, P.G., Turchi, G., Bellucci, G. and Bianchini, R. (1984) The reaction of 3,4-epoxy-1-butene with deoxyguanosine and DNA in vitro: synthesis and characterization of the main adducts. Carcinogenesis 5, 47-52.
4. De Meester, C. (1988) Genotoxic properties of 1,3-butadiene. Mutat. Res. 195, 273-281.
5. International Agency for Research on Cancer (1976) Diepoxybutane. IARC Monograph, Vol. 11, IARC, Lyon, France, pp. 115-123.
6. 32P-postlabeling. Carcinogenesis 15, 1903-1910.
7. Melnick, R.L. and Kohn, M.C. (1995) Mechanistic data indicate that 1,3-butadiene is a human carcinogen. Carcinogenesis 16, 157-163.
8. 32P-labeling test for DNA damage. Proc. Natl. Acad. Sci. USA 78, 6126-6129.
9. 32P-postlabeling assay based on the specific enzymatic conversion of bulky DNA lesions to radiolabeled dinucleotides and nucleoside 5′-monophosphates. Carcinogenesis 10, 1231-1239.
10. Schurdak, M.E. and Randerath, K. (1989) Effects of routes of administration on tissue distribution of DNA adducts in mice: comparison of 7H-dibenzo[c,g]carbazole, benzo[a]-pyrene, and 2-acetylaminofluorene. Cancer Res. 49, 2633-2638.
11. Van Duuren, B.L., Nelson, N., Orris, L., Palmes, E.D. and Schmitt, F.L. (1963) Carcinogenicity of epoxides, lactones, and peroxy compounds. J. Natl. Cancer Inst. 31, 41-55.