Dipyrone into the nucleus raphe magnus inhibits the rat nociceptive tail-flick reflex

European Journal of Pharmacology

Volumn 318, Issue 1, 1996, Pages 37-40

  Jones, Sharon L ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Descending inhibition; Nociception; Non steroidal anti inflammatory drug; Raphe magnus

Indexed keywords

DIPYRONE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; INTRACEREBRAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAT; SPINAL REFLEX;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DIPYRONE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICROINJECTIONS; PAIN MEASUREMENT; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; REFLEX;

EID: 0030604235     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00909-0     Document Type: Article

References (15)

1. Bannwarth, B., F. Demotes-Mainard, T. Schaeverbeke, L. Labat and J. Dehais, 1995, Central analgesic effects of aspirin-like drugs, Fundam. Clin. Pharmacol. 9, 1.
2. Basbaum, A.I. and H.L. Fields, 1978, Endogenous pain control mechanisms: review and hypothesis, Ann. Neurol. 4, 451.
3. Basbaum, A.I. and H.L. Fields, 1984, Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry, Annu. Rev. Neurosci. 7, 309.
4. Carlsson, K.-H. and I. Jurna, 1987, The role of descending inhibition in the antinociceptive effects of the pyrazolone derivatives, metamizol (dipyrone) and aminophenazone ('Pyramidon'), Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 154.
5. Carlsson, K.-H., J. Helmreich and I. Jurna, 1986, Activation of inhibition from the periaqueductal grey matter mediates central analgesic effect of metamizol (dipyrone), Pain 27, 373.
6. Fields, H.L., J. Bry, I. Hentall and G. Zorman, 1983, The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat, J. Neurosci. 3, 2545.
7. Gebhart, G.F., 1982, Opiate and opioid peptide effects on brain stem neurons: relevance to nociception and antinociceptive mechanisms, Pain 12, 93.
8. Hosobuchi, Y., J.E. Adams and R. Linchitz, 1977, Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone, Science 197, 183.
9. Malmberg, A.B. and T.L. Yaksh, 1992, Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat, J. Pharmacol. Exp. Ther. 263, 136.
10. Mayer, D.J., 1979, Endogenous analgesia systems: neural and behavioral mechanisms, in: Advances in Pain Research and Therapy, Vol. 3, eds. J.C. Liebeskind and D.G. Albe- Fessards (Raven Press, New York) p. 385.
11. Neugebauer, V., H.-G. Schaible, X. He, T. Lucke, P. Gundling and R.F. Schmidt, 1994, Electrophysiological evidence for a spinal antinociceptive action of dipyrone, Agents Actions 41, 62.
12. Shimada, S.G., I.G. Otterness and J.T. Stitt, 1994, A study of the mechanism of action of the mild analgesic dipyrone, Agents Actions 41, 188.
13. Tortorici, V. and H. Vanegas, 1994, Putative role of medullary off- and on-cells in the antinociception produced by dipyrone (metamizol) administered systemically or microinjected into PAG, Pain 57, 197.
14. Tortorici, V., E. Vasquez and H. Vanegas, 1996, Naloxone partial reversal of the antinociception produced by dipyrone microinjected into the periaqueductal gray of rats. Possible involvement of medullary off- and on-cells, Brain Res. 725, 106.
15. Yaksh, T.L. and T.A. Rudy, 1978, Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques, Pain 4, 299.