Kinetics of aluminum-induced inhibition of δ-aminolevulinic acid dehydratase in vitro

Biochemical Pharmacology

Volumn 52, Issue 6, 1996, Pages 927-931

  Schroeder, Tania M ^a   Caspers, Mary Lou ^a  

^a University of Detroit Mercy   (United States)

Author keywords

aluminum inhibition; heme biosynthesis; porphobilinogen synthetase; porphyrins; aminolevulinic acid dehydratase

Indexed keywords

ALUMINUM CHLORIDE; CITRIC ACID; ERYTHROCYTE ENZYME; HEME; LIVER ENZYME; PORPHOBILINOGEN SYNTHASE;

ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; ERYTHROCYTE; INTOXICATION; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030603966     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00449-2     Document Type: Article

References (26)

1. 1. Anderson PM and Desnick RJ, Purification and properties of δ-aminolevulinic acid dehydratase from human erythrocytes. J Biol Chem 254: 6924-6930, 1979.
2. 2. Tsukamoto I, Yoshinaga T and Sano S, The role of zinc with special reference to the essential thiol groups in δ-aminolevulinic acid dehydratase of bovine liver. Biochim Biophvs Acta 570: 167-178, 1979.
3. 3. Bevan DR, Bodlaender P and Shemin D, Mechanism of porphobilinogen synthase. J Biol Chem 255:2030-2035, 1980.
4. 4. Calissano P, Cartasegna C and Bonsignore D, Azione di alcuni metalli sull'ALA-deidratase eritrocitaria purificata da sangue umano. Lav Um 17: 493-497, 1965.
5. 5. Gibson KD, Neuberger A and Scott JJ, The purification and properties of δ-aminolevulinic acid dehydratase. Biochem J 61: 618-629, 1955.
6. 6. DeBruin A, Effect of lead exposure on the level of δ-aminolevulinic dehydratase activity. Med Lav 59: 411-418, 1968.
7. 7. Davis JR and Avram MJ, Correlation of the physicochemical properties of metal ions with their activation and inhibition of human erythrocytic δ-aminolevulinic acid dehydratase (ALAD) in vitro. Toxicol Appl Pharmacol 55: 281-290, 1980.
8. 8. Nakao K, Wada O and Yano Y, δ-Aminolevulinic acid dehydratase activity in erythrocytes for the evaluation of lead poisoning. Clin Chim Acta 19: 319-325, 1968.
9. 9. Connor EA, Yamauchi H and Fowler BA, Alterations on the heme biosynthetic pathway from the III-V semiconductor metal, indium arsenide (InAs). Chem Biol Interact 96: 275-285, 1995.
10. 10. Abdulla M, Svensson S and Haeger-Aronsen B, Antagonistic effects of zinc and aluminum on lead inhibition of δ-aminolevulinic acid dehydratase. Arch Environ Health 34: 464-469, 1979.
11. 11. Meredith PA, Moore MR and Goldberg A, Effects of aluminum, lead and zinc on δ-aminolaevulinic acid dehydratase. Enzyme 22: 22-27, 1977.
12. 12. Flora SJS, Dhawan M and Tandon SK, Effects of combined exposure to aluminum and ethanol on aluminum body burden and some neuronal, hepatic and haematopoietic biochemical variables in the rat. Hum Exp Toxicol 10: 45-48, 1991.
13. 13. Zaman K, Zaman W, Dabrowski Z and Miszta H, Inhibition of delta aminolevulinic acid dehydratase activity by aluminum. Comp Biochem Physiol 104C: 269-273, 1993.
14. 14. Kaiser L and Schwartz KA, Aluminum-induced anemia. Am J Kidney Dis 6:348-352, 1985.
15. 15. Ganrot PO, Metabolism and possible health effects of aluminum. Environ Health Perspect 65: 363-441, 1986.
16. 16. Buchet JP, Lauwerys R, Hassoun A, Dratwa M, Wens R, Collart F and Tielemans C, Effect of aluminum on porphyrin metabolism in hemodialyzed patients. Nephron 46: 360-363, 1987.
17. 17. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ, Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
18. 18. Labbe RF, Porphyrins and related compounds. In: Fundamentals of Clinical Chemistry (Ed. Tietz NW), pp. 455-473, Saunders, Philadelphia, 1976.
19. 19. Mauzerall D and Granick S, The occurrence and determination of δ-aminolevulic acid and porphobilinogen in urine. J Biol Chem 219: 435-446, 1956.
20. 20. Segel IH, Enzyme Kinetics. Wiley-Interscience, New York, 1975.
21. 21. Astin KH, Bishop DF, Wetmur JG, Kaul B, Davidow B and Desnick RJ, δ-Aminolevulinic acid dehydratase isozymes and lead toxicity. Ann NY Acad Sci 514: 23-29, 1987.
22. 22. Abraham NG, Levere RD and Freedman ML, Effect of age on rat liver heme and drug metabolism. Exp Gerontol 20: 277-281, 1985.
23. 23. Birchall JD and Chappell JS, Aluminum, chemical physiology and Alzheimer's disease. Lancet ii: 1008-1010, 1988.
24. 24. Martin RB, The chemistry of aluminum as related to biology and medicine. Clin Chem 12: 1797-1806, 1986.
25. 25. Jaffe EK, Salowe SP, Chen NT and DeHaven PA, Porphobilinogen synthase modification with methylmethanethiosulfonate. J Biol Chem 259: 5032-5036, 1984.
26. 26. Jaffe EK and Hanes D, Dissection of the early steps in the porphobilinogen synthase catalyzed reaction. J Biol Chem 261: 9348-9353, 1986.