ATP and P, γ-methylene ATP produce relaxation of guinea-pig isolated trachealis muscle via actions at P1 purinoceptors

European Journal of Pharmacology

Volumn 307, Issue 2, 1996, Pages 183-189

  Piper, Angela S ^a   Hollingsworth, Michael ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

8 Sulphophenyltheophylline; Adenosine 5' triphosphate; Guinea pig; Isolated; P1 purinoceptor; P2 purinoceptor; Suramin; Trachealis muscle

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; 8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE TRIPHOSPHATE; ADENOSINE UPTAKE INHIBITOR; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; BETA,GAMMA METHYLENEADENOSINE TRIPHOSPHATE; CARBACHOL; INDOMETACIN; NITROBENZYLTHIOINOSINE; PURINE P1 RECEPTOR ANTAGONIST; PURINE P2 RECEPTOR ANTAGONIST; PURINERGIC RECEPTOR AFFECTING AGENT; SURAMIN; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE; 4-NITROBENZYLTHIOINOSINE; 5' ADENYLYL (BETA,GAMMA METHYLENE)DIPHOSPHONATE; 5'-ADENYLYL (BETA,GAMMA-METHYLENE)DIPHOSPHONATE; 8-(4-SULFOPHENYL)THEOPHYLLINE; ALPHA,BETA-METHYLENEADENOSINE 5'-TRIPHOSPHATE; CHOLINERGIC RECEPTOR BLOCKING AGENT; DRUG DERIVATIVE; MERCAPTOPURINE RIBOSIDE; PURINE P2 RECEPTOR; THEOPHYLLINE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; FEMALE; GUINEA PIG; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; MUSCLE CONTRACTION; MUSCLE RELAXATION; PHYSIOLOGY; TRACHEA;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARBACHOL; FEMALE; GUINEA PIGS; INDOMETHACIN; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; PARASYMPATHOLYTICS; RECEPTORS, PURINERGIC P1; RECEPTORS, PURINERGIC P2; SURAMIN; THEOPHYLLINE; THIOINOSINE; TRACHEA;

EID: 0030603711     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00237-3     Document Type: Article

References (30)

1. 2 purinoceptors, Am. J. Respir. Cell Mol. Biol. 10, 1044.
2. Bailey, S.J. and S.M.O, Hourani, 1990, A study of the purinoceptors mediating contraction in the rat colon, Br. J. Pharmacol. 100, 753.
3. a adenosine receptor in the guinea pig trachea. Br. J. Pharmacol. 76, 381.
4. Burnstock, G., 1978, A basis for distinguishing two types of purinergic receptor, in: Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach, ed. R.W. Straub and L. Bolis (Raven Press, New York) p. 107.
5. Christie, J. and D.G. Satchell, 1980, Purine receptors in the trachea: is there a receptor for ATP? Br. J. Pharmacol. 70, 512.
6. Clanachan, A.S., T.P. Heaton and F.E. Parkinson, 1987, Drug interactions with nucleoside transport systems, in: Topics and Perspectives in Adenosine Research, ed. E. Gerlach and B.F. Becker (Springer-Verlag, Berlin) p. 118.
7. Clark, L.A., R.C. Small and M.J. Turnbull, 1980, Purine action on guinea-pig trachealis muscle: an attempt to characterise the purinoceptor. Br. J. Pharmacol. 69, 331P.
8. Collis, M.G., K.A. Jacobson and D.M. Tomkins, 1987, Apparent affinity of some 8-phenyl-substituted xanthines at adenosine receptors in guinea-pig aorta and atria, Br. J. Pharmacol. 92, 69.
9. Daziel, H.H. and D.P. Westfall, 1994, Receptors for adenine nucleotides and nucleosides: subclassification, distribution and molecular characterisation, Pharmacol. Rev. 46, 449.
10. 2 purinoceptor response in smooth muscle cells of guinea-pig taenia caeci, Eur. J. Pharmacol. 166, 531.
11. Den Hertog, A.D., J. Van Den Akker and A. Nelemans, 1989b, Suramin and the inhibitory junction potential in taenia caeci of the guinea-pig, Eur. J. Pharmacol. 173, 207.
12. 2 purinoceptor antagonist in the mouse vas deferens, Br. J. Pharmacol. 93, 243.
13. - channels, J. Pharm. Exp. Ther. 264, 210.
14. - channels and adenosine, J. Pharm. Exp. Ther. 264, 217.
15. Fredholm, B.B., M.P. Abbracchio, G. Burnstock, J.W. Daly, T.K. Harden, K.A. Jacobson, P. Leff and M. Williams, 1994. Nomenclature and classification of purinoceptors, Pharmacol. Rev. 46, 143.
16. Gustafsson, L.E., 1984, Adenosine antagonism and related effects of theophylline derivatives in guinea pig ileum longitudinal muscle, Acta Physiol. Scand. 122, 191.
17. 1 purinoceptors in smooth muscle, Br. J. Pharmacol. 104, 685.
18. 2-purinoceptor agonists and purinergic nerve stimulation in the guinea-pig urinary bladder and taenia coli, Br. J. Pharmacol. 99, 617.
19. 1 purinoceptors, Br. J. Pharmacol. 112, 503P.
20. 2X receptors in the rabbit ear artery, Br. J. Pharmacol, 101, 645.
21. Losinski, A. and S.P.H. Alexander, 1995. Adenosine receptor-mediated relaxation of guinea-pig precontracted, isolated trachea, Br. J. Pharmacol. 116, 2425.
22. Maguire, M.H. and D.G. Satchell, 1979, The contribution of adenosine to the inhibitory actions of adenine nucleotides on the guinea pig taenia coli: studies with phosphate modified adenine nucleotide analogues and dipyridamole, J. Pharmacol. Exp. Ther. 211, 626.
23. Maguire, M.H. and D.G. Satchell, 1981, Purinergic receptors in visceral smooth muscle, in: Purinergic Receptors. Receptors and Recognition Series B: Volume 12, ed. G. Burnstock (Chapman and Hall, London) p. 49.
24. Nicholls, J., S.M. Hourani and I. Kitchen, 1992, The ontogeny of purinoceptors in rat urinary bladder and duodenum, Br. J. Pharmacol. 105, 639.
25. Piper, A.S. and M. Hollingsworth, 1995, The purinoceptors of the guinea-pig isolated taenia caeci, Eur. J. Pharmacol. 280, 125.
26. Vane, J.R., 1971, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol. 231, 232.
27. Von Kügelgen, I., R. Bültmann and K. Starke, 1990, Interaction of adenine nucleotides, UTP and suramin in mouse vas deferens: suramin-sensitive and suramin-insensitive components in the contractile effect of ATP, Naunyn-Schmiedebergs Arch. Pharmacol. 342, 198.
28. Wardlaw, A.C., 1989, Practical Statistics for Experimental Biologists (John Wiley and Sons, London) p. 141.
29. Welford, L.A. and W.A. Anderson, 1988, Purine receptors and guinea pig trachea: evidence for a direct action of ATP, Br. J. Pharmacol. 95, 689.
30. Ziganshin, A.U., C.H.V. Hoyle and G. Burnstock, 1994, Ecto-enzymes and metabolism of extracellular ATP, Drug Dev. Res. 32, 134.